Navigation Links
Danish scientists detect new immune alert signal

Researchers from Aarhus University have now located the place in the human body where the earliest virus alert signal triggers the human immune system. They have also discovered a new alarm signal, which is activated at the very first sign of a virus attack.

The groundbreaking finding has just been published in the highly esteemed scientific journal Nature Immunology.

"It may turn out that patients suffering from frequent infections actually have problems with activating the mechanism that we have now detected," says Sren Riis Paludan, professor of immunology and virology at Aarhus University, who has completed the study together with Christian Holm, postdoc at Aarhus University.

Cell membrane triggers the alarm

Recent research indicates that our immune system is alerted about a threatening virus infection when genomic material from the virus enters the cell. Researchers from Aarhus University have revealed a process which is triggered already before the foreign genomic material enters the cell, i.e. in the membrane surrounding the cell.

"We have detected a new immune alarm signal, which helps the cells realize that they may soon get infected with virus," says Sren Riis Paludan.

Without this knowledge, the body cannot start fighting virus, which then may spread freely and possibly result in e.g. AIDS, hepatitis, influenza and cold sore.

Alarm signals in two directions

"The cellular membranes are in this situation comparable to a borderline territory in looming war and this is the place to put an outpost," says Christian Holm.

The 'outpost' will send alarm signals in two directions when danger is detected. One signal (outbound) will prepare the body for a possible attack, whereas the other signal (inbound) will make the cell investigate the threat.

"In the present study, we have revealed that this happens and what this process means. In future studies, we will investigate how this happens", the researchers say.

They add that this new knowledge could also lead to development of more efficient vaccines.

Contact: Christian Holm
Aarhus University

Related medicine news :

1. Scientists discover mechanism that promotes lung cancer growth and survival
2. Scientists Probe Diversity of Human Bodys Microbes
3. Proposed testosterone testing of some female olympians challenged by Stanford scientists
4. Scientists identify possible drug target for acute pancreatitis
5. Scientists Map the Tomatos Genome
6. Scientists discover gene which causes rare disease in babies
7. Scientists evaluate different antimicrobial metals for use in water filters
8. Scientists unravel role of fusion gene in prostate cancer
9. Kessler Foundation scientists present cognitive research findings at MS dual symposium
10. Scientists identify new target to battle rheumatoid arthritis
11. Scientists discover distinct molecular subtype of prostate cancer
Post Your Comments:
(Date:11/25/2015)... , ... November 25, 2015 , ... ... has been recognized once again for its stellar workplace culture with the company’s ... , Medical Solutions’ Cincinnati office was named a finalist in Cincinnati ...
(Date:11/25/2015)... (PRWEB) , ... November 26, 2015 , ... ... Union Commission (AUC), European Union (EU), ANDI Pan African Centres of Excellence, and ... Office in Nairobi (UNON) for the opening of the 5th African Network for ...
(Date:11/25/2015)... , ... November 25, 2015 , ... According to an ... robot is being more and more widely heralded as a breakthrough for performing hernia ... method has over traditional laparoscopic surgery is that it can greatly reduce the pain ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 25, 2015, ... for the Narconon network, announced the release of a new cutting edge recovery program ... organization has been working with drug- and alcohol-addicted individuals with the purpose to free ...
(Date:11/25/2015)... ... , ... On November 23rd 2015 Cozy Products, a division of ... Cozy Products explains what this means for business moving forward. , The Tri Lite ... business model: to sell personal heaters that reduce energy consumption, are economical and keep ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... KTOV ) (TASE: KTOV), a biopharmaceutical company focused on ... of various clinical conditions, today announced the closing of ... Depository Shares ( ADSs ), each representing 20 ordinary ... to 3,158,900 ADSs. The ADSs and warrants were issued ...
(Date:11/25/2015)...  Trovagene, Inc. (NASDAQ: TROV ), a developer ... Officer Antonius Schuh, Ph.D., is scheduled to present a ... Jaffray Healthcare Conference. th Annual Piper ... in New York on Tuesday, ... will be available for one-on-one meetings during the conference. ...
(Date:11/25/2015)... Nov. 25, 2015 Allergan plc (NYSE: ... and Rugen Therapeutics, a start-up  biotechnology company focused ... CNS disorders and funded by the F-Prime Biomedical ... entered into an exclusive collaboration to support the ... Spectrum Disorders (ASD) and Obsessive Compulsive disorders (OCD). ...
Breaking Medicine Technology: