Navigation Links
Danish scientists detect new immune alert signal
Date:6/22/2012

Researchers from Aarhus University have now located the place in the human body where the earliest virus alert signal triggers the human immune system. They have also discovered a new alarm signal, which is activated at the very first sign of a virus attack.

The groundbreaking finding has just been published in the highly esteemed scientific journal Nature Immunology.

"It may turn out that patients suffering from frequent infections actually have problems with activating the mechanism that we have now detected," says Sren Riis Paludan, professor of immunology and virology at Aarhus University, who has completed the study together with Christian Holm, postdoc at Aarhus University.

Cell membrane triggers the alarm

Recent research indicates that our immune system is alerted about a threatening virus infection when genomic material from the virus enters the cell. Researchers from Aarhus University have revealed a process which is triggered already before the foreign genomic material enters the cell, i.e. in the membrane surrounding the cell.

"We have detected a new immune alarm signal, which helps the cells realize that they may soon get infected with virus," says Sren Riis Paludan.

Without this knowledge, the body cannot start fighting virus, which then may spread freely and possibly result in e.g. AIDS, hepatitis, influenza and cold sore.

Alarm signals in two directions

"The cellular membranes are in this situation comparable to a borderline territory in looming war and this is the place to put an outpost," says Christian Holm.

The 'outpost' will send alarm signals in two directions when danger is detected. One signal (outbound) will prepare the body for a possible attack, whereas the other signal (inbound) will make the cell investigate the threat.

"In the present study, we have revealed that this happens and what this process means. In future studies, we will investigate how this happens", the researchers say.

They add that this new knowledge could also lead to development of more efficient vaccines.
'/>"/>

Contact: Christian Holm
chol@immunology.au.dk
45-20-96-87-54
Aarhus University
Source:Eurekalert

Related medicine news :

1. Scientists discover mechanism that promotes lung cancer growth and survival
2. Scientists Probe Diversity of Human Bodys Microbes
3. Proposed testosterone testing of some female olympians challenged by Stanford scientists
4. Scientists identify possible drug target for acute pancreatitis
5. Scientists Map the Tomatos Genome
6. Scientists discover gene which causes rare disease in babies
7. Scientists evaluate different antimicrobial metals for use in water filters
8. Scientists unravel role of fusion gene in prostate cancer
9. Kessler Foundation scientists present cognitive research findings at MS dual symposium
10. Scientists identify new target to battle rheumatoid arthritis
11. Scientists discover distinct molecular subtype of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 2016 , ... Leadership of Life Science Logistics (LSL), a ... earned its ISO 13485 certification, indicating the company’s quality control system for medical ... associated with ISO quality standard 13485. , BSI Group America, Inc., a ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... offering campers a multitude of activities from daily practices, arts & crafts, discussions, ... Camp Directors Amber East-D’Anna and Christy Evans have combined backgrounds in kids’ yoga, ...
(Date:5/26/2016)... ... May 26, 2016 , ... Power Systems, a ... first PowerWave Instructor Certification Course in Stoughton, Massachusetts. The course was led by ... through the 8 hour interactive course to qualify participants as certified PowerWave trainers. ...
(Date:5/26/2016)... ... May 26, 2016 , ... A health conscious snack that doesn't sacrifice taste? ... has ignited an undeniable buzz in the protein product community by offering an alternative ... These doughnuts are packed with 11 grams of protein and made from a healthy ...
(Date:5/26/2016)... Boston, MA (PRWEB) , ... May 26, 2016 ... ... working to enhance surgical safety efforts for several years, and the efforts have ... significantly decreased. These efforts include new standards of care to enhance perioperative patient ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 25,2016 FDA 510(k) clearance ... platform for urological and surgical applications ... of Cellvizio®, the multidisciplinary confocal laser endomicroscopy (CLE) ... the US with the 12 th 510(k) ... (FDA). This new FDA clearance covers Confocal Miniprobes ...
(Date:5/25/2016)... , May 25, 2016  According to Kalorama ... $381 billion in 2015.  Though these are challenging ... of opportunity for success for companies that remain ... search of new growth prospects medical device companies ... research and development (R&D) than do companies in ...
(Date:5/25/2016)... MedDay, a biotechnology company focused on the treatment ... "High doses of biotin in progressive multiple sclerosis: extension phase ... Ayman Tourbah , Principal Investigator of the Phase 3 ... Neurology (EAN) in Copenhagen, Denmark . The ... on Sunday, 29 May 2016 from 14:45 to 16:15 CEST ...
Breaking Medicine Technology: