Navigation Links
Danish scientists detect new immune alert signal
Date:6/22/2012

Researchers from Aarhus University have now located the place in the human body where the earliest virus alert signal triggers the human immune system. They have also discovered a new alarm signal, which is activated at the very first sign of a virus attack.

The groundbreaking finding has just been published in the highly esteemed scientific journal Nature Immunology.

"It may turn out that patients suffering from frequent infections actually have problems with activating the mechanism that we have now detected," says Sren Riis Paludan, professor of immunology and virology at Aarhus University, who has completed the study together with Christian Holm, postdoc at Aarhus University.

Cell membrane triggers the alarm

Recent research indicates that our immune system is alerted about a threatening virus infection when genomic material from the virus enters the cell. Researchers from Aarhus University have revealed a process which is triggered already before the foreign genomic material enters the cell, i.e. in the membrane surrounding the cell.

"We have detected a new immune alarm signal, which helps the cells realize that they may soon get infected with virus," says Sren Riis Paludan.

Without this knowledge, the body cannot start fighting virus, which then may spread freely and possibly result in e.g. AIDS, hepatitis, influenza and cold sore.

Alarm signals in two directions

"The cellular membranes are in this situation comparable to a borderline territory in looming war and this is the place to put an outpost," says Christian Holm.

The 'outpost' will send alarm signals in two directions when danger is detected. One signal (outbound) will prepare the body for a possible attack, whereas the other signal (inbound) will make the cell investigate the threat.

"In the present study, we have revealed that this happens and what this process means. In future studies, we will investigate how this happens", the researchers say.

They add that this new knowledge could also lead to development of more efficient vaccines.
'/>"/>

Contact: Christian Holm
chol@immunology.au.dk
45-20-96-87-54
Aarhus University
Source:Eurekalert

Related medicine news :

1. Scientists discover mechanism that promotes lung cancer growth and survival
2. Scientists Probe Diversity of Human Bodys Microbes
3. Proposed testosterone testing of some female olympians challenged by Stanford scientists
4. Scientists identify possible drug target for acute pancreatitis
5. Scientists Map the Tomatos Genome
6. Scientists discover gene which causes rare disease in babies
7. Scientists evaluate different antimicrobial metals for use in water filters
8. Scientists unravel role of fusion gene in prostate cancer
9. Kessler Foundation scientists present cognitive research findings at MS dual symposium
10. Scientists identify new target to battle rheumatoid arthritis
11. Scientists discover distinct molecular subtype of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... its affiliation with Tennessee Counseling Association. This new relationship allows TherapySites ... Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is extremely ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... technology to revolutionize the emergency ambulance transport experience for the millions of people ... how Uber has disrupted the taxi industry through the use of technology. Now, ...
(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
Breaking Medicine Technology: