Navigation Links
Dangerous blood pressure increases during exercise can be blocked, UT Southwestern researchers find
Date:4/4/2011

DALLAS April 5, 2011 UT Southwestern Medical Center researchers have identified one reason people with hypertension experience an even greater increase in their blood pressure when they exercise, and they've learned how to prevent the rise.

A study in a March issue of the Journal of Physiology reported that hypertensive people who exercise undergo decreased blood flow and oxygen in muscles. The scientists also identified a specific type of blood pressure medication that minimizes this effect.

"While there are many hypertension medications effective at lowering blood pressure at rest, very few are effective during exercise," said Dr. Wanpen Vongpatanasin, associate professor of internal medicine at UT Southwestern and lead author of the study. "People with high blood pressure need to exercise not only to help their blood pressure, but also their overall cardiovascular health."

Dr. Vongpatanasin said that some people with high blood pressure stop exercising out of fear of heart attack or stroke, and that sometimes physicians counsel those patients to limit activity because of those concerns.

While it's been known that blood pressure increases during exercise in people with hypertension, a mechanism behind the action and a way to block it in humans hadn't been identified previously.

Dr. Vongpatanasin and colleagues had 13 participants with mild hypertension and 13 with normal blood pressure perform hand grip exercises under regular conditions, followed by activity under conditions that affect a part of the nervous system that controls blood pressure.

They found increased nerve activity in hypertensive participants during exercise but not in those with normal blood pressure. Blood flow and oxygen levels in the arm muscles also fell more rapidly in the hypertensive group.

"In normal people, the body can increase blood flow to the working muscle despite increase in nerve activity, which tends to cause blood vessels to constrict," Dr. Vongpatanasin said. "Hypertensive patients have increased nerves and impaired ability to maintain muscle blood flow adequately."

Researchers then treated study participants with two types of blood pressure medications. An angiotensin receptor blocker, which prevents the hormone angiotensin from increasing blood pressure, increased blood flow during exercise. A diuretic that reduces blood pressure by stimulating sodium loss did not.

"Since nerve increases weren't reduced during treatment, we believe the angiotensin receptor blocker works directly on blood vessels to improve blood flow," Dr. Vongpatanasin said.

The next step, she said, will be to see if other hormones associated with angiotensin are involved in similar responses.


'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Yoga May Also Calm a Dangerous Irregular Heartbeat
2. Healthy Lifestyles Could Halve Cases of Dangerous Irregular Heartbeat
3. Dangerous Wandering a Lesser Known Side of Autism
4. Screening Seems to Catch Dangerous Heart Condition in Kids
5. New Antibiotic Helps Prevent Recurrence of Dangerous Gut Infection
6. Highly interactive training helps workers in dangerous jobs avoid deadly mistakes
7. Smog Contributes to Dangerous Heart Rhythm Disorders
8. Scientists Spot DNA Linked With Dangerous Heart Rhythms
9. New Blood Thinner May Help Fight Dangerous Leg Clots
10. Dangerous chemicals in food wrappers likely migrating to humans: U of T study
11. Pradaxa Approved to Fight Dangerous Irregular Heartbeat, Stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... June 24, 2017 , ... ... at 217 Portion Road in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable ... that visits to the dentist fit into their patients’ busy lifestyles. Dental365 also ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... announced the launch of Care Management Alerts and Dashboards, an innovative new service ... Rhode Island. , RIQI’s Care Management Alerts and Dashboards provide near real-time data ...
(Date:6/23/2017)... MA (PRWEB) , ... June 23, 2017 , ... ... Care Reconciliation Act (BCRA), their proposed healthcare bill to repeal and replace the ... May, the Senate bill would make significant cuts to Medicaid, a public health ...
(Date:6/23/2017)... ... 23, 2017 , ... Dr. Ran Y. Rubinstein , ... begun offering three new minimally invasive procedures to patients who want a younger ... Dr. Rubinstein is excited to bring microneedling, microneedling facials, and platelet rich plasma ...
(Date:6/23/2017)... ... 2017 , ... Goodcents Deli Fresh Subs today announced the opening of a ... 21st St. Topeka, Kan. 66604 (near 21st and Gage). It is owned and operated ... other locations in the Topeka and Bonner Springs, Kan. area. , “Goodcents has ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... years ago today, the Monterey Pop Festival opened its gates ... Francisco "Summer of Love."  To celebrate the anniversary, Northern Light® ... market research portals that it will begin delivering to customers ... "Summer of Love (For Our Customers)."  ... Northern Light ...
(Date:6/13/2017)... , June 13, 2017 Zimmer Biomet Holdings, Inc. ... today announced that the U.S. Food and Drug Administration (FDA) ... 3, 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter ... manufacturing facility is a measure of the progress we have ...
(Date:6/9/2017)... 9, 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders ... design, manufacture, sale and distribution of the AeroForm® Tissue ... of its commercial roll-out in the United ... than one hundred (100) medical institutions and health systems, ... a needle-free alternative for women who choose reconstructive surgery ...
Breaking Medicine Technology: