Navigation Links
Dangerous blood pressure increases during exercise can be blocked, UT Southwestern researchers find
Date:4/4/2011

DALLAS April 5, 2011 UT Southwestern Medical Center researchers have identified one reason people with hypertension experience an even greater increase in their blood pressure when they exercise, and they've learned how to prevent the rise.

A study in a March issue of the Journal of Physiology reported that hypertensive people who exercise undergo decreased blood flow and oxygen in muscles. The scientists also identified a specific type of blood pressure medication that minimizes this effect.

"While there are many hypertension medications effective at lowering blood pressure at rest, very few are effective during exercise," said Dr. Wanpen Vongpatanasin, associate professor of internal medicine at UT Southwestern and lead author of the study. "People with high blood pressure need to exercise not only to help their blood pressure, but also their overall cardiovascular health."

Dr. Vongpatanasin said that some people with high blood pressure stop exercising out of fear of heart attack or stroke, and that sometimes physicians counsel those patients to limit activity because of those concerns.

While it's been known that blood pressure increases during exercise in people with hypertension, a mechanism behind the action and a way to block it in humans hadn't been identified previously.

Dr. Vongpatanasin and colleagues had 13 participants with mild hypertension and 13 with normal blood pressure perform hand grip exercises under regular conditions, followed by activity under conditions that affect a part of the nervous system that controls blood pressure.

They found increased nerve activity in hypertensive participants during exercise but not in those with normal blood pressure. Blood flow and oxygen levels in the arm muscles also fell more rapidly in the hypertensive group.

"In normal people, the body can increase blood flow to the working muscle despite increase in nerve activity, which tends to cause blood vessels to constrict," Dr. Vongpatanasin said. "Hypertensive patients have increased nerves and impaired ability to maintain muscle blood flow adequately."

Researchers then treated study participants with two types of blood pressure medications. An angiotensin receptor blocker, which prevents the hormone angiotensin from increasing blood pressure, increased blood flow during exercise. A diuretic that reduces blood pressure by stimulating sodium loss did not.

"Since nerve increases weren't reduced during treatment, we believe the angiotensin receptor blocker works directly on blood vessels to improve blood flow," Dr. Vongpatanasin said.

The next step, she said, will be to see if other hormones associated with angiotensin are involved in similar responses.


'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Yoga May Also Calm a Dangerous Irregular Heartbeat
2. Healthy Lifestyles Could Halve Cases of Dangerous Irregular Heartbeat
3. Dangerous Wandering a Lesser Known Side of Autism
4. Screening Seems to Catch Dangerous Heart Condition in Kids
5. New Antibiotic Helps Prevent Recurrence of Dangerous Gut Infection
6. Highly interactive training helps workers in dangerous jobs avoid deadly mistakes
7. Smog Contributes to Dangerous Heart Rhythm Disorders
8. Scientists Spot DNA Linked With Dangerous Heart Rhythms
9. New Blood Thinner May Help Fight Dangerous Leg Clots
10. Dangerous chemicals in food wrappers likely migrating to humans: U of T study
11. Pradaxa Approved to Fight Dangerous Irregular Heartbeat, Stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... The ... among the top five firms in the “2015/2016 Best in KLAS: Software and ... Staffing. KLAS is a research and insights firm on a global mission to ...
(Date:2/11/2016)... FL (PRWEB) , ... February 11, 2016 , ... ... and advocates will discuss how to improve care by making data on heart ... heart disease. The Summit on Transparency and Public Reporting of Pediatric and Congenital ...
(Date:2/11/2016)... ... , ... In a new paper published in the latest ... J. Rohrich, and colleagues, examine and underscore the importance of upper lateral cartilage ... addressing this vital area. , The upper lateral cartilage in rhinoplasty, refers to ...
(Date:2/11/2016)... ... February 11, 2016 , ... veEDIS Clinical ... technology, with highly adaptable algorithms, has been updated to help Emergency Department physicians ... symptoms consistent with Zikas and a travel history to affected regions, or potential ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... trainer and author Ray Clarke poses a question as a challenge for his ... his book, "Being in the Being" (published by Partridge Singapore), Clarke explores the ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , February 11, 2016 Breast Cancer ... the Asia-Pacific (APAC) breast cancer market ... $3.4 billion by 2021, at a Compound Annual Growth Rate ... Asia-Pacific Markets to 2021 - states that the ... considerable expansion from $1.9 billion in 2014 to $3.4 billion ...
(Date:2/11/2016)... 11, 2016 --> ... new research report, titled "Sports Medicine Devices Market - Global ... 2019". According to the report, the global sports medicine devices ... 2013 to 2019, growing from a value of US$6.1 bn ... --> --> The global sports medicine devices ...
(Date:2/11/2016)... Jeffrey Zucker , vice president ... present at this year,s Summit for Clinical Operations Executives (SCOPE), ... Miami, FL. Zucker will discuss how sponsors ... supporting SCOPE,s "Improving Site Study Activation and Performance" portion of ... 25 at 11:05 a.m. --> ...
Breaking Medicine Technology: