Navigation Links
Dangerous Side Effect Found in Cancer Immunotherapy Research

Lab experiment resulted in T-cells spreading beyond treatment area

TUESDAY, June 3 (HealthDay News) -- When scientists first began looking into using the body's own immune system to target malignancies, it was hoped that the therapy would be able to zero in on a specific cancer without affecting healthy tissue.

While the original theory is still worth pursuing, researchers have found some potentially harmful side effects.

The findings, published in the June 10 issue of the Proceedings of the National Academy of Sciences, concluded that a skin cancer immunization therapy created a dangerous consequence.

"The ultimate lesson to be learned from this report is that all treatments have potential side effects, and we have to be very thoughtful about potential side effects," said Dr. Louis M. Weiner, director of the Lombardi Comprehensive Cancer Center at Georgetown University in Washington, D.C. "We have to be very thoughtful about how we apply those treatments, who we apply those treatments for, and how we follow the patients we treat to assure appropriate safety."

Cancer vaccines are developed to stimulate the body's own immune system to fight off deadly cancers. Ideally, the target of the vaccine will be very specific to the tumor, but this is not always the case: Antigens, or molecules that provoke antibody production, that are found only on the tumor are usually found also only in individual patients. Other antigens are shared between patients but are also found in normal cells, leading to the possibility that the vaccine will kill healthy cells along with malignant ones.

The investigators on this study, from the National Cancer Institute, plucked T-cells from the bloodstream of mice, cultured the cells in the lab to mount a response against a melanoma-related target, GP10, then re-injected the T-cells into the mice to fight the cancer. Melanoma is a particularly lethal form of cancer that starts on the skin.

Such a therapy can cause depigmentation of the skin and, sometimes, attacks on the thyroid.

"Those problems tend to be irritating but not life-threatening, and if they are the price that one has to pay for a cure or highly effective treatment for a highly deadly disease, most patients are willing to pay the price," Weiner said.

But in this particular investigation, the eye also became a target. "That carries with it more profound consequences, although they could inject steroids into the eye that would kill the T-cells in the eye," Weiner said. (This would produce a local effect only and would not affect the melanoma treatment itself.)

"As we develop increasingly more effective immune therapy strategies that are capable of attacking self, be it a self-tumor or self-normal organ, there may well be potentially surprising prices to pay in terms of toxicities," Weiner said. "The authors suggest that understanding the consequences of new immunotherapies for cancer should help researchers guide future treatments and anticipate and treat side effects, thus preventing healthy cells from getting caught in the crossfire."

More information

Learn more about cancer vaccines at the National Cancer Institute.

SOURCES: Louis M. Weiner, M.D., director, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C.; June 10, 2008, Proceedings of the National Academy of Sciences

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New method effective in detecting dangerous coronary plaque
2. Mobile Phones: More Dangerous Than Smoking
3. Antipsychotics Dangerous for Elderly With Dementia
4. Drowsy Drivers Make Holiday Weekend Among the Most Dangerous
5. Drowsy Driving as Dangerous as Drunk Driving
6. Mothers Pass Dangerous Toxins to Babies Through Breast Milk
7. Lung transplants not dangerous for children with cystic fibrosis, after all
8. How dangerous is boxing for the brain?
9. Fort Dodges Mosquito Shot Offers Convenient Protection Against Dangerous Mosquito-Borne Illnesses
10. The price paid for higher energy is highly dangerous to teeth
11. LightAir Cleans the Air From the Smallest and Most Dangerous Particles Without Generating Ozone
Post Your Comments:
Related Image:
Dangerous Side Effect Found in Cancer Immunotherapy Research 
(Date:11/30/2015)... Madeira Beach, FL (PRWEB) , ... November 30, ... ... issue of Consumer Reports magazine, quoted Michael Hansen, Ph.D., a senior scientist at ... exposure, and even more so for a child’s exposure limits. , The original ...
(Date:11/30/2015)... ... November 30, 2015 , ... Medicalis, a ... Radiology Society of North America (RSNA) annual meeting, being held November 29 – ... 2014. Throughout 2015, the company has completed installations for Integrated Delivery Network ...
(Date:11/30/2015)... ... ... It’s inevitable that everyone will experience death in his or her lifetime. ... lives among us. It is your perspective, however, that determines how you view death ... T Sky understands that she may see death more frequently than most. As she ...
(Date:11/30/2015)... ... ... The successful filing of an Investigational New Drug application (IND) is a ... key industry segment, Regis Technologies has decided to sponsor and participate in an XTalks-hosted ... , Federal law does not allow new drugs to cross state lines until it ...
(Date:11/30/2015)... ... ... Scott Newman MD, FACS of New York’s Advanced Plastic ... the New York City area to utilize the new, non-invasive SculpSure™ Laser System ... for fat loss in the abdomen, flanks, and other areas that is completely ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015  PTS Diagnostics, the U.S.-based manufacturer of ... analyzers, A1CNow ® systems, and PTS Detect™ cotinine ... patents that will propel the company into the mHealth ... Europe . The technology is a system ... on smartphones and tablets, and uses test strip technology ...
(Date:11/30/2015)... NASHUA, N.H. , Nov. 30, 2015 /PRNewswire/ ... today that it will feature its latest solutions ... the early identification of cancer at the Radiological ... in Chicago from November ... showcase recent product advances including iReveal®, an automated ...
(Date:11/30/2015)... -- Hanger, Inc. (NYSE: HGR ) (the "Company") today ... its previously announced consent solicitation (as amended and restated, ... amount 7⅛% Senior Notes due 2018 (the "Notes") to ... pursuant to the Consent Solicitation, (ii) the proposed increased ... date of the Consent Solicitation.    ...
Breaking Medicine Technology: