Navigation Links
Dana-Farber Scientists find potential loophole in pancreatic cancer defenses

BOSTON--Dana-Farber Cancer Institute scientists and colleagues have discovered that pancreatic cancer cells' growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer.

Cancer cells are known to "rewire" their metabolic circuits differently from normal cells to provide energy for cancerous growth. A study published today in Nature reveals that pancreatic tumor cells are dependent on an amino acid, glutamine, which they utilize via a molecular pathway that has no apparent backup system.

"Pancreatic cancer cells have painted themselves into a metabolic bottleneck," said Dana-Farber's Alec Kimmelman, MD, PhD, co-senior author of the publication with Lewis Cantley, PhD, of Weill Cornell Medical College. Their research showed "that if you suppress any enzyme in that pathway, the cancer cells cannot effectively compensate and they can no longer grow," Kimmelman said.

Moreover, the investigators said, this novel glutamine pathway in pancreatic tumors does not appear to be important for normal cells, suggesting that inhibitor drugs could block cancer cells' growth without harming healthy tissues and organs.

"We don't have a drug to do this in humans," Kimmelman said, "but we are working on inhibitors of enzymes in the glutamine pathway."

The research showed that the cancer gene KRAS, which is the "signature" genetic mutation occurring in pancreatic cancer, directs the metabolic rewiring that creates the tumors' dependence on the glutamine pathway. KRAS, Kimmelman explained, changes the expression of key enzymes that maintain this pathway.

Pancreatic cancer is one of the most lethal and treatment-resistant of all cancers, with a dismal survival rate, and scientists have been searching for any vulnerability that could be exploited. One of the newer strategies in cancer research is studying the metabolic differences between cancer cells and normal cells with the goal of depriving tumors of their fuel.

In order to grow, cells must prevent the accumulation of damaging oxygen "free radicals," and they do so by maintaining a chemical "redox balance." The researchers found that when they blocked any of several enzyme reactions in the glutamine pathway, it undermined redox balance and suppressed the growth of human pancreatic cancer cells transplanted to mice.

If drugs can be developed to shut down the glutamine pathway, Kimmelman suggested, they might make pancreatic tumors more susceptible to standard treatments, such as radiation and chemotherapy, that cause free radicals to accumulate in cancer cells.

Contact: Teresa Herbert
Dana-Farber Cancer Institute

Related medicine news :

1. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
2. Scientists solving the mystery of human consciousness
3. Scientists uncover multiple faces of deadly breast cancer
4. Scientists identify major source of cells defense against oxidative stress
5. Scientists tailor cell surface targeting system to hit organelle ZIP codes
6. Scientists rewrite rulebook on breast cancer in landmark global study
7. Warwick scientists uncover how checkpoint proteins bind chromosomes
8. NIH scientists link quickly spreading gene to Asian MRSA epidemic
9. Joslin scientists identify important mechanism that affects the aging process
10. Scripps Research scientists show how memory B cells stay in class to fight different infections
11. Scientists Map Melanomas Genome
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
(Date:6/23/2016)... 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered ... Latin America . ... ... ... ...
Breaking Medicine Technology: