Navigation Links
Dana-Farber Scientists find potential loophole in pancreatic cancer defenses
Date:3/27/2013

BOSTON--Dana-Farber Cancer Institute scientists and colleagues have discovered that pancreatic cancer cells' growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer.

Cancer cells are known to "rewire" their metabolic circuits differently from normal cells to provide energy for cancerous growth. A study published today in Nature reveals that pancreatic tumor cells are dependent on an amino acid, glutamine, which they utilize via a molecular pathway that has no apparent backup system.

"Pancreatic cancer cells have painted themselves into a metabolic bottleneck," said Dana-Farber's Alec Kimmelman, MD, PhD, co-senior author of the publication with Lewis Cantley, PhD, of Weill Cornell Medical College. Their research showed "that if you suppress any enzyme in that pathway, the cancer cells cannot effectively compensate and they can no longer grow," Kimmelman said.

Moreover, the investigators said, this novel glutamine pathway in pancreatic tumors does not appear to be important for normal cells, suggesting that inhibitor drugs could block cancer cells' growth without harming healthy tissues and organs.

"We don't have a drug to do this in humans," Kimmelman said, "but we are working on inhibitors of enzymes in the glutamine pathway."

The research showed that the cancer gene KRAS, which is the "signature" genetic mutation occurring in pancreatic cancer, directs the metabolic rewiring that creates the tumors' dependence on the glutamine pathway. KRAS, Kimmelman explained, changes the expression of key enzymes that maintain this pathway.

Pancreatic cancer is one of the most lethal and treatment-resistant of all cancers, with a dismal survival rate, and scientists have been searching for any vulnerability that could be exploited. One of the newer strategies in cancer research is studying the metabolic differences between cancer cells and normal cells with the goal of depriving tumors of their fuel.

In order to grow, cells must prevent the accumulation of damaging oxygen "free radicals," and they do so by maintaining a chemical "redox balance." The researchers found that when they blocked any of several enzyme reactions in the glutamine pathway, it undermined redox balance and suppressed the growth of human pancreatic cancer cells transplanted to mice.

If drugs can be developed to shut down the glutamine pathway, Kimmelman suggested, they might make pancreatic tumors more susceptible to standard treatments, such as radiation and chemotherapy, that cause free radicals to accumulate in cancer cells.
'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Related medicine news :

1. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
2. Scientists solving the mystery of human consciousness
3. Scientists uncover multiple faces of deadly breast cancer
4. Scientists identify major source of cells defense against oxidative stress
5. Scientists tailor cell surface targeting system to hit organelle ZIP codes
6. Scientists rewrite rulebook on breast cancer in landmark global study
7. Warwick scientists uncover how checkpoint proteins bind chromosomes
8. NIH scientists link quickly spreading gene to Asian MRSA epidemic
9. Joslin scientists identify important mechanism that affects the aging process
10. Scripps Research scientists show how memory B cells stay in class to fight different infections
11. Scientists Map Melanomas Genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
(Date:6/23/2016)... , June 23, 2016 ... Oticon , industry leaders in advanced ... launch of Oticon Opn ™, the world,s first ... of possibilities for IoT devices.      (Photo: ... Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: