Navigation Links
Dana-Farber/Children's Hospital Boston study identifies possible therapy for radiation sickness
Date:11/23/2011

BOSTONA combination of two drugs may alleviate radiation sickness in people who have been exposed to high levels of radiation, even when the therapy is given a day after the exposure occurred, according to a study led by scientists from Dana-Farber Cancer Institute and Children's Hospital Boston.

Mouse studies of other potential therapies suggest they would be effective in humans only if administered within a few minutes or hours of radiation exposure, making them impractical for use in response to events involving mass casualties. In contrast, the larger time window for administering the two-drug regimen raises the prospect that it could become a mainstay of the response to public health threats such as a nuclear power plant accident or nuclear terror attack.

In a paper published online by the journal Science Translational Medicine, the scientists report the beneficial effects, in mice, of a combination of a fluoroquinolone antibiotic (similar to the commonly used human antibiotic ciprofloxacin, or "Cipro") and a synthetic version of the natural human infection-fighting protein BPI. Mice that received the combination a day after being exposed to high doses of radiation fared far better than mice that received neither or only one of the agents. Whereas radiation exposures of that magnitude almost always prove fatal within a month, 80 percent of the mice that received the two agents were alive and apparently healthy a month into the study.

The study's lead author is Eva Guinan, MD, of Dana-Farber, and the senior author is Ofer Levy, MD, PhD, of Children's Hospital Boston.

The investigators also found that the ability to generate new blood cells which can shut down in the aftermath of radiation exposure rebounded much more quickly and vigorously in the mice treated with fluoroquinolone and rBPI21 (the synthetic version of BPI), potentially contributing to their return to health.

"Both fluoroquinolone a
'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. More Blacks Die in Hospital After Diverticulitis Surgery
2. Patients fare just as well if their nonemergency angioplasty is performed at hospitals
3. UH Rainbow Babies & Childrens Hospital begins studies on vitamin D to prevent heart disease
4. Hospital safety climate linked to both patient and nurse injuries: Drexel study
5. St. Michaels Hospital receives Grand Challenges Explorations funding
6. University Hospitals Case Medical Center neurosurgeons champion brain bypass in select patients
7. The Childrens Hospital of Philadelphia receives Grand Challenges Explorations funding
8. Prostate cancer surgery better at teaching hospitals
9. Hospital for special surgery physician-scientists share advances in rheumatology research
10. Latex gloves lead to lax hand hygiene in hospitals, study finds
11. Hospital Rooms Crawling With Drug-Resistant Germs: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... October 30, 2014 Don Allred Insurance, ... health insurance plans for North Carolina residents, is excited ... in Burlington’s Holly Hill Mall. The new branch has ... already helping customers through all facets of the insurance ... Allred Insurance spokesman Scott Allred couldn’t be happier with ...
(Date:10/30/2014)... 30, 2014 Five months after their ... Street LLC announces new branding and a website to ... . After David Mepham’s promotion to name partner earlier ... website to include Mepham’s name and better reflect their ... mediation firm, the decision to implement new branding reflects ...
(Date:10/30/2014)... N.C. (PRWEB) October 30, 2014 Paramount ... health care, is increasing efforts to help people save ... expenses continue to increase for prescription drugs in the ... valuable savings and resources to bridge the relationship between ... One of the biggest challenges people face today with ...
(Date:10/30/2014)... HealthDay Reporter , WEDNESDAY, Oct. 29, ... prostate cancer who also have certain heart problems may increase ... study suggests. , , The therapy in question is called androgen ... levels of male hormones to prevent the growth of cancer ... this hormone therapy was linked to triple the risk of ...
(Date:10/30/2014)... By Dennis Thompson ... -- The Ebola outbreak in Liberia -- one of three ... slowing, World Health Organization officials said Wednesday. Dr. Bruce ... in the number of burials in Liberia and no increase ... the global push to tame the epidemic may be making ...
Breaking Medicine News(10 mins):Health News:Allred Insurance Satellite Office Grand Opening 2Health News:Hodgkinson Street Mepham Rebrands 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 3
... , PORTLAND, Ore., July 29 While Congress debates ... its work to engage consumers to transform health care from the ... System - Engaging Consumers to Create Value-Driven Health Care," designed for ... and from Healthcare Marketing Report,s Annual Healthcare Advertising Awards. An interactive ...
... Death risk only 0.3 percent, chances of serious complications ... For those considering bariatric surgery to combat significant obesity, ... be much lower than what has previously been reported. ... surgery and laparoscopic adjustable gastric banding (lap-band surgery), found ...
... , , ST. LOUIS, July 29 ... quarter net income from continuing operations of $192.0 million, or $0.74 ... related to the previously announced acquisition of WellPoint,s pharmacy benefit management ... $0.76 for the same period last year. These earnings for the ...
... , , , SAN DIEGO, ... medical device company focused on developing products for minimally disruptive surgical ... of Finance and Investor Relations, is scheduled to present at the ... Hotel in New York, New York, on Wednesday, August 5, 2009, ...
... , COLUMBUS, Ohio, July 29 Roxane ... Drug Application (ANDA) for Risperidone Oral Solution, 1mg/mL by the ... 30mL bottles for immediate shipment to wholesalers and pharmacies nationwide. ... 1mg/mL are AA rated to RISPERDAL(R) (risperidone) oral solution. Annual ...
... , WASHINGTON, July 29 Three of the ... by supporting the Obama health-care plan, which would foster a ... sex education, euthanasia and eugenics. , , ... , , Catholic Charities USA, the Society ...
Cached Medicine News:Health News:Regence Wins Awards for Consumer Appeal to Transform Health Care 2Health News:Study Finds Weight-Loss Surgery Safer Than Thought 2Health News:Study Finds Weight-Loss Surgery Safer Than Thought 3Health News:Express Scripts Reports Strong Second Quarter Earnings 2Health News:Express Scripts Reports Strong Second Quarter Earnings 3Health News:Express Scripts Reports Strong Second Quarter Earnings 4Health News:Express Scripts Reports Strong Second Quarter Earnings 5Health News:Express Scripts Reports Strong Second Quarter Earnings 6Health News:Express Scripts Reports Strong Second Quarter Earnings 7Health News:Express Scripts Reports Strong Second Quarter Earnings 8Health News:Express Scripts Reports Strong Second Quarter Earnings 9Health News:Express Scripts Reports Strong Second Quarter Earnings 10Health News:Express Scripts Reports Strong Second Quarter Earnings 11Health News:Express Scripts Reports Strong Second Quarter Earnings 12Health News:Express Scripts Reports Strong Second Quarter Earnings 13Health News:Express Scripts Reports Strong Second Quarter Earnings 14Health News:NuVasive to Present at the BMO Capital Markets 9th Annual Focus on Healthcare Conference 2Health News:NuVasive to Present at the BMO Capital Markets 9th Annual Focus on Healthcare Conference 3Health News:Roxane Laboratories, Inc. Announces the Launch of Risperidone Oral Solution 1mg/mL 2Health News:Catholic Charities, Vincent De Paul Society Supporting Abortion-Providing Healthcare Plan, Says ALL 2
(Date:10/30/2014)... 2014 Boston Scientific Corporation (NYSE: ... Credit Suisse Annual Healthcare Conference on Tuesday, November 11, ... Dan Brennan , executive vice president and chief financial ... at approximately 8:00 a.m. PT followed by a question ... the presentation and question and answer session will be ...
(Date:10/30/2014)... , Oct. 30, 2014 CVS Health (NYSE: ... new clinical affiliations with three leading regional health systems to ... The collaborating health systems include Baptist Health System in ... which include Commonwealth Health in Pennsylvania , ... Arizona , and Tennova Healthcare in Tennessee ...
(Date:10/30/2014)... --  BioLife Solutions , Inc. (NASDAQ: BLFS ... clinical grade hypothermic storage and cryopreservation ... for cells and tissues, today announced today that ... released on Thursday, November 6, 2014, and that the ... at 1:30 p.m. PST that afternoon. Management will provide ...
Breaking Medicine Technology:Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 2CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 3CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 4BioLife Solutions to Report Financial Results for Third Quarter 2014 and Provide Business Update on November 6, 2014 2
... 2 adjustable belt buckle. You adjust once and ... off your shoulders. And now theres our Lady ... anatomy. ,For additional back support try one of ... on the vertebrae and help lift the apron ...
The Easy Wrap Apron is now available with an attached Thyroid Collar. The Thyroid Collar is held on with velcro so it adjusts to fully protect the neck. This Apron with Collar is available in 5mm lea...
The major innovation in posterior stabilized (PS) knee design. Improve patellofemoral kinematics. Reduce wear rate potential. Increase resistance to posterior tibial dislocation. Achieve at least 120...
StelKast's Proven™ Knee System is a long term high quality solution based on a clinically proven and successful design....
Medicine Products: