Navigation Links
Dana-Farber/Children's Hospital Boston study identifies possible therapy for radiation sickness
Date:11/23/2011

BOSTONA combination of two drugs may alleviate radiation sickness in people who have been exposed to high levels of radiation, even when the therapy is given a day after the exposure occurred, according to a study led by scientists from Dana-Farber Cancer Institute and Children's Hospital Boston.

Mouse studies of other potential therapies suggest they would be effective in humans only if administered within a few minutes or hours of radiation exposure, making them impractical for use in response to events involving mass casualties. In contrast, the larger time window for administering the two-drug regimen raises the prospect that it could become a mainstay of the response to public health threats such as a nuclear power plant accident or nuclear terror attack.

In a paper published online by the journal Science Translational Medicine, the scientists report the beneficial effects, in mice, of a combination of a fluoroquinolone antibiotic (similar to the commonly used human antibiotic ciprofloxacin, or "Cipro") and a synthetic version of the natural human infection-fighting protein BPI. Mice that received the combination a day after being exposed to high doses of radiation fared far better than mice that received neither or only one of the agents. Whereas radiation exposures of that magnitude almost always prove fatal within a month, 80 percent of the mice that received the two agents were alive and apparently healthy a month into the study.

The study's lead author is Eva Guinan, MD, of Dana-Farber, and the senior author is Ofer Levy, MD, PhD, of Children's Hospital Boston.

The investigators also found that the ability to generate new blood cells which can shut down in the aftermath of radiation exposure rebounded much more quickly and vigorously in the mice treated with fluoroquinolone and rBPI21 (the synthetic version of BPI), potentially contributing to their return to health.

"Both fluoroquinolone a
'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. More Blacks Die in Hospital After Diverticulitis Surgery
2. Patients fare just as well if their nonemergency angioplasty is performed at hospitals
3. UH Rainbow Babies & Childrens Hospital begins studies on vitamin D to prevent heart disease
4. Hospital safety climate linked to both patient and nurse injuries: Drexel study
5. St. Michaels Hospital receives Grand Challenges Explorations funding
6. University Hospitals Case Medical Center neurosurgeons champion brain bypass in select patients
7. The Childrens Hospital of Philadelphia receives Grand Challenges Explorations funding
8. Prostate cancer surgery better at teaching hospitals
9. Hospital for special surgery physician-scientists share advances in rheumatology research
10. Latex gloves lead to lax hand hygiene in hospitals, study finds
11. Hospital Rooms Crawling With Drug-Resistant Germs: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... Baptist Medical Center Jacksonville’s cancer program has received ... American College of Surgeons. , To earn the three-year ... Commission on Cancer quality care standards, be evaluated every ... of excellence in the delivery of comprehensive patient-centered care. ... locally at a CoC-accredited cancer center, they are gaining ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 " QuickPick Travel ... Biz Report, which takes a look small, medium, and large ... reporter for NewsWatch and a business expert, conducted the business ... platform to plan up to three weeks of vacation for ... family and friends, and explore the world. And when people ...
(Date:5/5/2015)... NY (PRWEB) May 05, 2015 ProTexting, ... that enables businesses to deploy Mobile Engagement Campaigns and ... Contact . ProTexting clients can now leverage the power ... by collecting and syncing subscribers’ e-mail addresses into the ... “We have recognized that the growing trend of multi-channel ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 Barnabas Health, ... the launch of a new healthy cooking video series ... two semi-finalist on Bravo’s Top Chef, teamed up with ... wellness and healthy living. In support of the ... Website and the videos will be showcased on social ...
(Date:5/5/2015)... Don’t have time to go to ... membership? Don’t know which workout equipment to use? ... to help members achieve their heath and fitness goals ... educational, caused-based wellness company, today announces the launch of ... led by certified trainers, nutritional information and recipes provided ...
Breaking Medicine News(10 mins):Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 2Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 3Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 4Health News:A Platform to Plan the Perfect Vacation was Featured on NewsWatch Television 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 3Health News:Barnabas Health Teams Up With Celebrity Chef Sam Talbot To Launch "Life Is Better Healthy" Cooking Video Series 2Health News:Barnabas Health Teams Up With Celebrity Chef Sam Talbot To Launch "Life Is Better Healthy" Cooking Video Series 3Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 2Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 3
... Grieving Children and Families , , CAMP HILL, Pa. ... volunteers on Monday, June 15 at the Radisson Penn Harris ... hours - an average of nearly 35 hours each during ... and their families at the Caring Place facility in Lemoyne. ...
... June 11 Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ), ... a company overview at the Jefferies 3rd Annual Healthcare Conference on ... , , A live audio webcast of the ... Company,s Web site, www.isispharm.com . A replay ...
... Combined with Significant Operating Efficiencies Lead to Jump in Earnings , ... Registry (CBR), the global leader in the collection and preservation ... growth in first quarter 2009, up nearly 20 percent compared to ... gains due to increases in both volume and market share coupled ...
... 11 Cord Blood America, Inc. (OTC Bulletin Board: ... cell preservation companies ( http://www.cordblood-america.com ... stem cells to families nationwide and internationally, said today ... into the European Union, specifically Belgium and Italy. , ...
... ... Converged Management Appliance (CMA) and AMD ADEN™ Solution Offers laptop and desktop-based telehealth ... ... [Nasdaq: PLCM, the global leader in telepresence, video, and voice communications solutions, and ...
... ... 1420058959, 592 pages) with a complete CD-ROM by Perry Hookman MD can be purchased ... ... practicing physicians are sued annually for malpractice. Nurses, pharmacists and other healthcare professionals are ...
Cached Medicine News:Health News:Highmark Caring Place To Honor Midstate Volunteers 2Health News:Highmark Caring Place To Honor Midstate Volunteers 3Health News:Cord Blood Registry Maintains Solid Growth in First Quarter 2009 2Health News:Cord Blood Registry Maintains Solid Growth in First Quarter 2009 3Health News:Cord Blood America Continuing European Expansion 2Health News:Polycom and AMD Global Telemedicine Inc. To Deliver Integrated Visual And Voice Telehealth Capability To Clinicians On-The-Go 2Health News:Polycom and AMD Global Telemedicine Inc. To Deliver Integrated Visual And Voice Telehealth Capability To Clinicians On-The-Go 3Health News:Want to Learn How to Testify? New Home Study Course by Practicing Physician Teaches Medical Malpractice Defendants and Physicians How to be Effective in Court 2Health News:Want to Learn How to Testify? New Home Study Course by Practicing Physician Teaches Medical Malpractice Defendants and Physicians How to be Effective in Court 3
(Date:5/5/2015)... , May 5, 2015 Zimmer Holdings, Inc. (NYSE ... announced that its Board of Directors has approved the payment ... quarter of 2015. The cash dividend of $0.22 ... 2015, to stockholders of record as of the close of ... subject to approval of the Board of Directors and may ...
(Date:5/5/2015)... FRANCISCO , May 5, 2015 Silver ... Small Business Innovation Research (SBIR) grant from the National ... is a San Francisco based ... to selectively repair tissues damaged by disease. This award ... engineered to repair heart tissue following a heart attack. ...
(Date:5/5/2015)... SAN DIEGO, May 5, 2015  Trovagene, Inc. ... today reported its financial results for the three ... "In the first quarter, we presented favorable clinical ... Lung Cancer Conference, demonstrating our Precision Cancer Monitoring ... in pancreatic, colorectal, and lung cancers," said Antonius ...
Breaking Medicine Technology:Silver Creek Pharmaceuticals Awarded NIH SBIR Grant for Smart Growth Factor Technology 2Trovagene, Inc. Announces First Quarter 2015 Financial Results 2Trovagene, Inc. Announces First Quarter 2015 Financial Results 3Trovagene, Inc. Announces First Quarter 2015 Financial Results 4Trovagene, Inc. Announces First Quarter 2015 Financial Results 5Trovagene, Inc. Announces First Quarter 2015 Financial Results 6
Angled tip, 0.3mm triangular grasping tips; In Titanium....
... A necessary addition ... set, the Reichert Trial ... fit and smooth controls ... fitting.,The robust design, high-quality ...
... Master is designed and constructed ... service and give the professional ... procedures. It embodies the characteristics ... most, including accuracy, speed, ease, ...
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
Medicine Products: