Navigation Links
Dana-Farber/Children's Hospital Boston study identifies possible therapy for radiation sickness
Date:11/23/2011

BOSTONA combination of two drugs may alleviate radiation sickness in people who have been exposed to high levels of radiation, even when the therapy is given a day after the exposure occurred, according to a study led by scientists from Dana-Farber Cancer Institute and Children's Hospital Boston.

Mouse studies of other potential therapies suggest they would be effective in humans only if administered within a few minutes or hours of radiation exposure, making them impractical for use in response to events involving mass casualties. In contrast, the larger time window for administering the two-drug regimen raises the prospect that it could become a mainstay of the response to public health threats such as a nuclear power plant accident or nuclear terror attack.

In a paper published online by the journal Science Translational Medicine, the scientists report the beneficial effects, in mice, of a combination of a fluoroquinolone antibiotic (similar to the commonly used human antibiotic ciprofloxacin, or "Cipro") and a synthetic version of the natural human infection-fighting protein BPI. Mice that received the combination a day after being exposed to high doses of radiation fared far better than mice that received neither or only one of the agents. Whereas radiation exposures of that magnitude almost always prove fatal within a month, 80 percent of the mice that received the two agents were alive and apparently healthy a month into the study.

The study's lead author is Eva Guinan, MD, of Dana-Farber, and the senior author is Ofer Levy, MD, PhD, of Children's Hospital Boston.

The investigators also found that the ability to generate new blood cells which can shut down in the aftermath of radiation exposure rebounded much more quickly and vigorously in the mice treated with fluoroquinolone and rBPI21 (the synthetic version of BPI), potentially contributing to their return to health.

"Both fluoroquinolone a
'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. More Blacks Die in Hospital After Diverticulitis Surgery
2. Patients fare just as well if their nonemergency angioplasty is performed at hospitals
3. UH Rainbow Babies & Childrens Hospital begins studies on vitamin D to prevent heart disease
4. Hospital safety climate linked to both patient and nurse injuries: Drexel study
5. St. Michaels Hospital receives Grand Challenges Explorations funding
6. University Hospitals Case Medical Center neurosurgeons champion brain bypass in select patients
7. The Childrens Hospital of Philadelphia receives Grand Challenges Explorations funding
8. Prostate cancer surgery better at teaching hospitals
9. Hospital for special surgery physician-scientists share advances in rheumatology research
10. Latex gloves lead to lax hand hygiene in hospitals, study finds
11. Hospital Rooms Crawling With Drug-Resistant Germs: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... July 01, 2015 , ... Amada Senior Care, premier provider ... in the greater Phoenix area – their Mesa, Arizona location . Amada franchise ... with their purchase of the rights to the area after years of experience in ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... healthcare providers, has been retained to lead a national chief executive officer ... executive search firms in the healthcare industry, B. E. Smith has recently placed ...
(Date:7/1/2015)... ... July 01, 2015 , ... Research published in the journal ... app to test eyesight was just as accurate as those from standard paper-based charts ... Tropical Medicine is responsible for the development of the test, which does not depend ...
(Date:7/1/2015)... ... , ... The Recovery Workforce Summit: 2015 PRA Annual Conference , presented ... Atlantic, as a keynote on June 2nd in Philadelphia, PA. Stossel led a timely ... added power and reach to the essential message, while opening doors to wellness and ...
(Date:7/1/2015)... ... July 01, 2015 , ... These listings will give families ... sober companionship and delivery to wilderness therapy or treatment facilities. Therapeutic Experts ... with anxiety, ADHD, autism spectrum disorders, eating disorders, severe learning disabilities, addiction treatment, ...
Breaking Medicine News(10 mins):Health News:Amada Senior Care Expands to Greater Phoenix Area 2Health News:Citizens Medical Center Retains B. E. Smith to Recruit New CEO 2Health News:Citizens Medical Center Retains B. E. Smith to Recruit New CEO 3Health News:New Research Shows Reliability of Peek Eye Testing Mobile App 2Health News:New Research Shows Reliability of Peek Eye Testing Mobile App 3Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 2Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 3Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 4Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 5Health News:All Kinds of Therapy – Announces New Partnership Feature, Therapeutic Experts 2
... HealthDay Reporter , MONDAY, Nov. 8 (HealthDay News) -- A ... drugs called statins do not reduce their risk for colorectal ... the risk of colorectal cancer. But this new study ... of the type of statin taken or for how long. ...
... November, 2010 Saints Medical Center is pleased ... hospitalist department, has received a patent for a lightweight plastic ... Stethguard is a V-shaped clear plastic cover that ... where most of the germs and bacteria are located. ...
... to restore retinal health in the eyes of diabetic mice has ... it might do the same for people. "We want to ... devastation that can occur with diabetes," said Dr. Sylvia Smith, retinal ... Medical College of Georgia. "That means we need to know more ...
... It is well known that oral infection progressively destroys ... loss in adults. A major goal of periodontal treatment ... most current therapies cannot predictably promote repair of tooth-supporting ... clinically using bone grafts and guiding tissue membranes with ...
... New research suggests that a newer drug works no better ... treatment for a type of vasculitis, a rare blood vessel ... kid on the block," said Dr. Ronald Falk, a kidney ... news because relapses and serious side effects are common over ...
... MONDAY, Nov. 8 (HealthDay News) -- A solar-powered blood-pressure measuring ... rates of cardiovascular disease in low-income nations, according to a ... Africa -- two in Uganda and one in Zambia -- ... agreement with the standard blood-pressure testing method for systolic blood ...
Cached Medicine News:Health News:Statins Don't Reduce Colon Cancer Risk, Study Finds 2Health News:Statins Don't Reduce Colon Cancer Risk, Study Finds 3Health News:Mass. doctor invents product to curb hospital-acquired infections 2Health News:Potential drug therapy for diabetic retinopathy under study 2Health News:Potential drug therapy for diabetic retinopathy under study 3Health News:Growth factor regenerates tooth supporting structures: Results of a large randomized clinical trial 2Health News:Cheaper, Older Treatment for Vasculitis Beats Out New Drug 2Health News:Solar Blood-Pressure Device Shows Promise for Use in Poor Nations 2
(Date:6/30/2015)... new report released today from the Institute of Medicine ... training opportunities to reduce barriers to the provision of ... of CPR and AED use by bystanders remain less ... even though evidence indicates that its use ... strongly supports the IOM,s recommendation to encourage training through ...
(Date:6/30/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/54fkmt/global_array ... "Global Array Instruments Market 2015-2019" report to ... market to grow at a CAGR of 12.48 ... array instruments market can be divided into three ... tissue microarrays and cell microarrays. This report covers ...
(Date:6/30/2015)...  Today, the National Mobility Equipment Dealers Association (NMEDA) ... Awareness Month Local Heroes Contest on National TV. The ... received 1.3 million votes. The sponsors for the wheelchair ... , and Valley Honda Dealers , with the ... Mobility International (VMI) and ElDorado Mobility .  ...
Breaking Medicine Technology:New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 2New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 3New Recommendations in Cardiac Arrest Protocol Advocate for Increased CPR and AED Training to Improve U.S. Survival Rates 4Global Array Instruments Market 2015-2019 - Advances in Personalized Medicines with Affymetrix, Agilent Technologies & Illumina Dominating 2NMEDA Announces National Contest Winners 2NMEDA Announces National Contest Winners 3
Full Handle Laseredge Slit Blade Knife, 2.85 mm angled bevel up. Blade tip dimension: 14.4 mm x 2.8 mm x 3.7 mm....
Full Handle Laseredge Slit Blade Knife, 2.8 mm angled double bevel. Blade tip dimension: N/A x 2.8 mm x N/A....
Full Handle Laseredge Slit Blade Knife, 2.5 mm angled bevel up. Blade tip dimension: 14.4 mm x 2.5 mm x 3.7 mm....
Full Handle Laseredge Implant Blade Knife, 5.7 mm round tip. Blade dimension: 16.5 mm x 5.7 mm x 4.2 mm x 2.4 mm....
Medicine Products: