Navigation Links
Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
Date:5/31/2012

BOSTONA novel compound has become the first targeted therapy to benefit patients with the most common genetic subtype of lung cancer, an international clinical trial led by scientists at Dana-Farber Cancer Institute and other institutions will report at the annual meeting of the American Society of Clinical Oncology (ASCO) June 1-5 in Chicago.

Pasi A. Jnne, MD, PhD, scientific co-director of Dana-Farber's Belfer Institute for Applied Cancer Science, will present the findings from the randomized phase II study (abstract 7503) on Monday, June 4, 3 p.m. CT, E Hall D2, McCormick Place.

The study involved 87 non-small cell lung cancer (NSCLC) patients whose tumors carry a mutation in the gene KRAS. Such tumors account for about 20 percent of NSCLC cases, but no targeted therapy has proved effective against them in previous clinical research. The drug under investigation, selumetinib, doesn't attack KRAS directly, but interferes with one of its molecular henchmen, a protein called MEK.

Participants in the study all had advanced stages of the disease. They received the standard chemotherapy agent docetaxel in combination with either selumetinib or a placebo.

By many measures the rate and duration of response to treatment, change in tumor size, and proportion of patients alive and showing no signs of advancing disease -- the group receiving selumetinib did significantly better than the other group. Most clinically significant were the improved rate of response to treatment (37 percent compared to 0 percent in the placebo arm) and prolonged progression-free survival (5.3 months compared to 2.1 months in the placebo arm). Although patients in the selumetinib group survived longer, on average, than those in the placebo group 9.4 months compared to 5.2 months the improvement was not considered statistically significant.

"This clinical trial demonstrates that a combination of chemotherapy and selumetinib is significantly
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Humans Can Sniff Out Old Age in Others, Study Shows
2. Infant Smarts Similar With Different Types of Formula: Study
3. Pre-op Treatments Boost Survival for Esophageal Cancer Patients: Study
4. Cooling Helps Oxygen-Deprived Newborns: Study
5. Immigrant women giving birth in Spain suffer great stress, a study warns
6. Once-Obese Women Still Face Stigma, Study Finds
7. Surly People Tend to Like Fierce Dogs, Study Shows
8. Nordic Walking a Winner for Heart Failure Patients, Study Says
9. Common Painkillers May Help Prevent Skin Cancer: Study
10. Antioxidant shows promise as treatment for certain features of autism, Stanford study finds
11. Tight Blood-Sugar Control Shows Mixed Results for Health of Kidneys: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who consistently delivers ... to have it lead the wedding dress industry into the ... dresses for the global market. , “The CEO of VogueQueen ... focuses on continuing the goal of operational excellence and giving ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many trendy ... on Facebook, Twitter, and Pinterest. The fans will have an ... lottery every week. , Moreover, the company has extended its ... Angelweddingdress homepage for more information. , Angelweddingdress is ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently released ... website of AngelWeddingDress.com to find more details. , ... for a bridal party. AngelWeddingDress offers a variety of ... maternity wedding dresses are specially designed for 2015. , ...
(Date:1/22/2015)... Orlando, Florida (PRWEB) January 22, 2015 ... up today at the 2015 PGA Merchandise Show to ... lady and incredible female amateur golfer, Arlene McKitrick. The ... career female amateur golf tournament win. She won her ...
(Date:1/22/2015)... Thousand of GranuFlo lawsuits ( http://www.granuflolawsuit2014.com/ ... GranuFlo and NaturaLyte dialysis concentrates continue to move forward ... Court, District of Massachusetts, Bernstein Liebhard LLP reports. According ... remanded a case filed by the state of Louisiana ...
Breaking Medicine News(10 mins):Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4
... taken ill after taking mid-day meal and a spoonful of ... meal Friday was given as part of the national child ... seven, are from the government-run primary school in Chitwapur locality. ... and has been put on ventilator. The others are on ...
... ban on the illegal sale of sperms allegedly being carried ... Federation of Obstetric and Gynaecological Societies of India (FOGSI) has ... and checks by sperm banks, was a serious matter and ... in Kanpur this week, FOGSI also asked the government to ...
... University at Buffalo has shown that a new compound may ... count and low percentage sperm motility. ,The sperm ... AM-1346. After incubation, there was a doubling in the fertilizing ... ,Lani Burkman, Ph.D., and colleagues presented the findings at ...
... to receive a lung transplant? ,“There is no ... answer when the guidelines for lung transplantation// were written in ... available,” explained Dr. Philip W. Smith, a surgery resident and ... ,Since lung transplantation (LTX) was first performed in 1983, ...
... sleep, and is a major problem for children and their ... enuresis) respond to desmopressin, 30% do not. ,Danish ... urine of these children who do not respond to the ... may possibly be due to an imbalance of prostaglandin, which ...
... women who grow up in cities or move there from rural ... Diana was known to suffer from this eating disorder.It is a ... to London as a teenager. ,Bulimia is an eating ... over-eating and vomiting or purging. This study has observed a ...
Cached Medicine News:Health News:New Compound May Improve Fertility in Smokers 2Health News:New Compound May Improve Fertility in Smokers 3Health News:Elderly Lung Transplant Patients More Likely to Survive 2Health News:Elderly Lung Transplant Patients More Likely to Survive 3Health News:Hope For Bedwetting Children 2Health News:Hope For Bedwetting Children 3Health News:Hope For Bedwetting Children 4
(Date:1/23/2015)... 2015  CytoSorbents Corporation (NASDAQ CM: CTSO), a critical ... adsorber to reduce deadly inflammation in critically-ill and ... net of transaction costs, in non-dilutive funding as ... Certificate Transfer Program sponsored by the New Jersey ...
(Date:1/22/2015)... privately held medical device company, announced today that it ... Corporation (Tokyo Stock Exchange TYO: 8001) to sell its ... in Japan . ViewRay,s technology, the ... MRI-guided radiation therapy system that images and treats cancer ...
(Date:1/22/2015)... OAKS, Calif. , Jan. 22, 2015  Amgen (NASDAQ: ... and full year 2014 financial results on Tuesday, Jan. 27, 2015, ... be followed by a conference call with the investment community at ... Robert A. Bradway , chairman and chief executive officer, and ...
Breaking Medicine Technology:CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
... , , ... ... ... ...
... , , CHAPEL HILL, N.C. ... to adjust its sales force structures in the face of marketplace ... to new research from Best Practices, LLC. , One of the ... territory size to better focus reps on customer needs, according to ...
Cached Medicine Technology:Beverly Hills Eye Surgeon Gets Surprise Inundation of Requests From Around the World for Information About New Treatment That Saved USA Bobsled Captain Steve Holcomb's Eyesight 2Beverly Hills Eye Surgeon Gets Surprise Inundation of Requests From Around the World for Information About New Treatment That Saved USA Bobsled Captain Steve Holcomb's Eyesight 3Beverly Hills Eye Surgeon Gets Surprise Inundation of Requests From Around the World for Information About New Treatment That Saved USA Bobsled Captain Steve Holcomb's Eyesight 4Beverly Hills Eye Surgeon Gets Surprise Inundation of Requests From Around the World for Information About New Treatment That Saved USA Bobsled Captain Steve Holcomb's Eyesight 5Beverly Hills Eye Surgeon Gets Surprise Inundation of Requests From Around the World for Information About New Treatment That Saved USA Bobsled Captain Steve Holcomb's Eyesight 6As Biopharma Companies Reshape Sales Model, Most See Resetting Territory Size and Implementing Individualized Call Plans as First Steps Toward Change, According to New Research From Best Practices, LLC 2As Biopharma Companies Reshape Sales Model, Most See Resetting Territory Size and Implementing Individualized Call Plans as First Steps Toward Change, According to New Research From Best Practices, LLC 3
... Merit Medical is pleased to ... procedures. The pre-coated, high-performance, InQwire guide ... which is very lubricious and can ... is available in a wide range ...
BiodivYsio stent with biocompatible coating (phosphorylcholine)...
PT wires combine the enhanced durability of a linear elastic nitinol distal core and a highly resilient polymer tip. This provides excellent access in difficult cases involving severe tortuosity, tig...
9mm Gently Curved Jaws, WIth Lock, in Titanium....
Medicine Products: