Navigation Links
Dana-Farber, Brigham and Women's launch large-scale genomic database project
Date:10/24/2011

BOSTON -- Committed to speeding the development of cancer treatments that target the genetic weaknesses in each patient's tumor, Dana-Farber Cancer Institute and Brigham and Women's Hospital have launched Profile, a major effort to scan tumor tissue from adult cancer patients for hundreds of gene mutations linked to cancer.

The program, nearly two years in development, is one of the most extensive research projects in cancer genomics yet undertaken nationally. Open to every adult cancer patient seen in the Brigham and Women's and Dana-Farber Longwood Medical Area clinics, the program aims to build a comprehensive database for research into the genetic makeup of different cancer types and, ultimately, into treatments that are most effective against individual tumors. (The program will be extended to pediatric cancer patients at Dana-Farber and Children's Hospital Boston in the coming year.)

Clinicians at Dana-Farber/Brigham and Women's Cancer Center currently use targeted therapies that pinpoint genetic mutations in a select number of cancers, including colon, lung, breast, and some leukemias and sarcomas. The new research program is focused on identifying a far greater number of mutations for a wider array of cancers, ultimately enabling clinicians to treat more cancers with targeted therapies in the future.

"Profile will put us firmly on the path to realizing the promise of personalized medicine. By 'genotyping' each tumor identifying the set of mutations that drive it we'll be able to design therapies geared specifically to those mutations, depriving the tumor of the ability to sustain itself while producing a minimum of side effects," says Dana-Farber's Chief Scientific Officer Barrett Rollins, MD, PhD, one of the architects of the program. "We're laying the foundation for the development, testing, and implementation of such therapies, and we expect the project to grow as we discover new cancer-related gene mutations and with the development of new technologies."

Tissue-testing for the program will be performed with OncoMap, a system custom-designed for genomic research in cancer by investigators at Dana-Farber and the Broad Institute of MIT and Harvard. Using high-speed, high-capacity robotic machinery to prepare, sort, and scan tumor tissue, the system makes it possible to quickly process large numbers of tumor tissue samples with a high degree of accuracy.

"We've learned a great deal about the role of specific mutated genes in cancer, and we now have technology for testing large numbers of tumor samples for those mutations," says Janina Longtine, MD, director of Molecular Diagnostics at Brigham and Women's Hospital and a senior leader of the research program. "For the first time, we have the opportunity to build a critical mass of genomic data that can be used to bring better treatments to patients."

Research has shown that tumors that look and act alike can carry different sets of mutations, which influence how cancers grow, spread, and respond to treatment. Only by collecting data on a mass scale can researchers hope to capture the enormous diversity of cancer at the genetic level, program leaders say. By identifying a tumor's molecular characteristics, clinicians will be able to select the appropriate treatment for the each patient. A patient whose tumor carries a particular mutation would receive a drug known to be effective against that mutation in specific types of tissue. Although this currently happens in a minority of cancer cases, the goal of the Dana-Farber/Brigham and Women's project is to find ways to apply this to many more patients.

In contrast to programs that scan particular types of tumors for a small number of gene mutations, Profile tests tumor samples for nearly 500 cancer mutations in 41 genes. Program leaders anticipate that well over 10,000 people will participate in the program during the first year and every year thereafter.

Study participants will have their tumor tissue scanned and information from their medical record on the course of their disease, its response to treatment, relapse, and side effects will be placed in a second, separate database. By linking data from these two sources, researchers will be able to study which therapies are most effective against particular tumor types.

The study participants also can have the results of their OncoMap testing sent to their Dana-Farber or Brigham physician. The tumor-testing program was developed primarily for research purposes, but leaders expect that some participants may immediately benefit by learning of their eligibility for current clinical trials.

Longtine and Rollins anticipate that Profile will expand with the discovery of additional cancer-related mutations and the development of more advanced screening technologies.


'/>"/>
Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Related medicine news :

1. Brigham and Women's Hospital Launches Stork Fund
2. Brigham and Womens Hospital selected to participate in Medicare imaging demonstration project
3. Brigham and Womens Hospital researcher receives NIH Transformative Research Project Award
4. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
5. CustomerCentric Selling and Kadient Announce Joint Event in Boston to Launch Strategic Partnership for Sales Enablement and Improvement
6. Top New York Dentists at Smile in the City Launch New Web Site
7. Medical Transcription Services and EHR Provider MxSecure Launches New Enhanced Website with Goal of Improved Physician Productivity
8. Caring Rose Home Care Launched To Help Seniors Live Independently
9. MSU launches first anti-counterfeiting research program
10. ChangingHomeCare.com Launches Effort to Promote Future of Homecare
11. Bariatricfurnishings.com Launches Unique Eco-friendly Seating for Health Care, Hospitality, Assisted Living Centers, and Home Use at Competitive Prices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2016)... (PRWEB) , ... May 29, 2016 , ... Whole Health ... Amazon.com, their new KlipPro KP-240L clipper is available to the public. This is an ... is substantially wider than the average clipper. , Everything about this product is concentrated ...
(Date:5/28/2016)... ... May 28, 2016 , ... After a year and a half of planning the ... extraordinary event. The Multiple Pathways of Recovery Conference was held May 2 -4, 2016 ... and the United Kingdom came together to explore the many pathways individuals use to get ...
(Date:5/27/2016)... ... , ... W.S. Badger Co. Inc ., the maker of certified organic ... one of the best small businesses for new dads by Fatherly, the digital lifestyle ... providing progressive benefits to new parents on the organization’s 2016 Best Places to ...
(Date:5/27/2016)... ... May 27, 2016 , ... In response ... many who are unaware of the plight of aphasia. In collaboration with the ... “Stroke Awareness” campaign. , The link between stroke and aphasia is relatively unknown, ...
(Date:5/27/2016)... ... ... With a team of certified experts, Validation Center is ... GMP accreditation, Validation Center is also a registered authority of the international system ... Validation Center is ISO17025 accredited and only offers its clients the latest technology, ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 LabStyle ... Dario™ Diabetes Management Tool, today announced that the Company,s Chief ... Marcum MicroCap Conference being held June 1-2 in ... being held June 7-9 in Los Angeles, CA. ... discuss recent corporate and operational milestones, including the U.S. FDA ...
(Date:5/27/2016)... Kitov Pharmaceuticals ... late-stage drug development, today announced the completion of ... batches required for registration of KIT-302 with the ... Kitov,s announcement in December 2015, that ... primary efficacy endpoint. "We are fortunate ...
(Date:5/26/2016)... 2016 According to a new market ... - U.S. Industry Analysis, Size, Share, Growth, Trends, and Forecast ... U.S. was valued at US$ 5.89 Bn in 2014 and ... 2015 to 2023 to reach US$ 7.99 Bn in 2023. ... emerging needle free drug delivery devices and the market is ...
Breaking Medicine Technology: