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Damon Runyon Cancer Research Foundation grants fellowship awards to 21 top young scientists
Date:7/10/2012

ponsor Dianne K. Newman, PhD, at the California Institute of Technology, Pasadena, California, is studying metabolism of compounds called polyphosphates in Pseudomonas aeruginosa, a bacterial pathogen that can lead to lethal infections in immunocompromised cancer patients. Polyphosphates are found from bacteria to mammalian cells. A better understanding of polyphosphate metabolism in a model bacterial pathogen may aid in the design of treatments for cancer-associated pathogens and may also shed light on the poorly understood role of polyphosphates in mammalian cell growth.

Christopher J. Shoemaker, PhD, with his sponsors Vlad Denic, PhD, and Andrew W. Murray, PhD, at Harvard University, Cambridge, Massachusetts, is studying autophagy, a process of cellular housekeeping and energy generation. The activation of autophagy can facilitate cancer drug resistance. By better understanding the processes that govern autophagy, he ultimately seeks to limit the effects of drug resistance during cancer treatment.

Michael J. Smanski, PhD [HHMI Fellow] with his sponsor Christopher A. Voigt, PhD, at Massachusetts Institute of Technology, Cambridge, Massachusetts, is examining magnetic nanoparticles (MNPs), which possess unique physical properties that have led to several clinical applications in cancer diagnosis and therapy. Several species of bacteria have been found to naturally produce MNPs with exquisite control over size and shape that is unmatched by current chemical synthesis methods. He aims to understand how bacterial synthesis of MNPs relies on the coordinated expression of several dozen genes.

Stephanie C. Weber, PhD [HHMI Fellow] with her sponsors Clifford P. Brangwynne, PhD, and Howard A. Stone, PhD, at Princeton University, Princeton, New Jersey, is investigating control of cell size. She aims to understand how the size and activity of the nucleolus, a subnuclear organelle that has been implicated in tumorigenesis, contributes to cell, tis
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Contact: Yung S. Lie, Ph.D.
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

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