Anne H. Bothmer, PhD [Jake Wetchler Foundation Fellow for Pediatric Innovation] with her sponsor Pier Paolo Pandolfi, MD, PhD, at Beth Israel Deaconess Medical Center, Boston, Massachusetts, is studying how the function of ribosomes, cellular machines responsible for making protein, is changed in cancer cells. She plans to characterize how ribosomes in cancerous cells differ from those in normal cells, and to test whether these differences contribute to the development of diseases such as acute myeloid leukemia (AML). Elucidating how cancer cells differ from normal cells will ultimately contribute to the development of novel therapeutic options for the treatment of cancer.
Angela N. Brooks, PhD, with her sponsor Matthew L. Meyerson, MD, PhD, at Dana-Farber Cancer Institute, Boston, Massachusetts, is analyzing cancer genome sequence data to identify DNA mutations that affect RNA splicing, a form of gene processing and regulation. By characterizing these mutations, her work will provide further understanding of the role of splicing alterations in cancer as well as insight into the functional consequences of cancer mutations.
Gamze . Camdere, PhD, with her sponsor Douglas E. Koshland, PhD, at the University of California, Berkeley, California, is using structural biological analysis and in vitro assays to understand how a protein called cohesion interacts with DNA. Cohesin is required for proper chromosome segregation, DNA repair, gene expression, and overall maintenance of genomic integrity. A better understanding of cohesin will provide important insights int
|Contact: Yung S. Lie, Ph.D.|
Damon Runyon Cancer Research Foundation