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Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators
Date:6/19/2008

General Hospital, Boston, Massachusetts, is examining the relationship between small RNAs and nuclear organization. The organization of the genome is of particular importance because defects can result in misregulation of genes, missegregation of chromosomes during cell division, and instability of the genome, all of which are thought to be early steps in cancer progression.

  • Avi Priel, PhD, with his sponsor David J. Julius, PhD, at the University of California, San Francisco, California, is identifying molecules that contribute to pain sensation under normal or disease states, such as cancer, with special focus on molecules that confer temperature sensation.

  • Melanie A. Samuel, PhD, with her sponsor Joshua R. Sanes, PhD, at Harvard University, Cambridge, Massachusetts, is investigating age-related changes that occur in the nervous system and the molecules that cause these alterations. Because aging, cancer susceptibility, and neural function are molecularly linked, these studies may identify factors that promote healthy aging and also enhance cancer resistance.

  • Timothy O. Street, PhD, with his sponsor David A. Agard, PhD, at the University of California, San Francisco, California, is investigating the molecular mechanism by which the Hsp90 protein chaperone affects the folding of substrate proteins. The effect of Hsp90 on folding is important because this chaperone activates a wide variety of proteins that are over-expressed in cancerous cells.

  • Elaine M. Youngman, PhD, with her sponsor Craig C. Mello, PhD, at the University of Massachusetts Medical School, Worcester, Massachusetts, is examining how small noncoding RNAs control gene expression. Understanding this novel regulatory mechanism may provide paths to new therapeutic strategies for the treatment of many types of cancer.

  • Xiaomeng Milton Yu, PhD, with his sponsor Liqun Luo, PhD, at Stanford University, Stanford, California, is studying how a c
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  • Contact: Yung S. Lie, Ph.D.
    yung.lie@damonrunyon.org
    212-455-0520
    Damon Runyon Cancer Research Foundation
    Source:Eurekalert

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