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Damon Runyon Cancer Research Foundation awards $3.45 million to 9 top young clinical investigators
Date:6/21/2011

lignant skin cancer associated with a novel polyoma virus. She plans to characterize T cells present in MCC. The goal is to use this information to better identify patients at risk for this cancer and to develop novel effective tumor vaccines.

Dr. Clark works under the mentorship of Thomas S. Kupper, MD, at Brigham and Women's Hospital, Boston, Massachusetts.

Vassiliki Karantza, MD, PhD

Dr. Karantza is examining the role of autophagy in tumor cell survival and responsiveness to chemotherapy. Autophagy is a process of "cellular self-digestion" that is used by both normal cells and tumor cells as a survival mechanism in times of metabolic stress, such as nutrient and oxygen deprivation. She will use the Continuation Grant to pursue novel studies examining the role of autophagy in pregnancy-associated breast cancer. She also plans to conduct a clinical trial combining autophagy inhibition with other existing therapies for treatment of certain types of pancreatic cancer, for which there is a need for more effective treatment options.

Dr. Karantza works under the mentorship of Robert S. DiPaola, MD, at UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Elahe A. Mostaghel, MD, PhD [Genentech Investigator]

Dr. Mostaghel is defining key mechanisms underlying resistance of prostate cancer to hormone treatment. Suppression of the hormone testosterone is currently the most effective treatment for advanced prostate cancer; however, tumors frequently develop resistance to this therapy. The Continuation Grant will enable her to continue developing novel treatments for prostate cancer that can be rapidly moved into the clinic.

Dr. Mostaghel works under the mentorship of Peter S. Nelson, MD, at the Fred Hutchinson Cancer Research Center, Seattle, Washington.


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Contact: Yung S. Lie, Ph.D.
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

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