Jean Y. Tang, MD, PhD
Basal cell carcinoma (BCC) is the most common type of skin cancer. Mutations in the Hedgehog (HH) signaling pathway are frequently found in these cancers. Early-stage clinical studies of a HH pathway inhibitor drug have been successful, with 55% of patients reported to respond. However, most tumors change during the course of therapy and drug resistance eventually develops.
Dr. Tang, a dermatologist, will characterize mechanisms of drug resistance and identify new drug combinations that are effective in treatment of BCC. The ultimate goal of her research is to prevent or delay drug resistance. Her studies have the potential to benefit patients with BCC as well as those with other HH-dependent cancers, such as medulloblastoma.
Dr. Tang works under the mentorship of Philip A. Beachy, PhD, and Ervin H. Epstein, MD, at Stanford University, Stanford, California.
2011 Clinical Investigator Continuation Grants
Andrew T. Chan, MD, MPH
Dr. Chan is developing molecular "smart" probes and novel imaging techniques for earlier and improved detection of colorectal cancer. The Continuation Grant will be used to complete a clinical trial testing an innovative high-definition non-fiberoptic imaging system for both colonoscopy and upper endoscopy. This work also has the potential to accelerate the discovery and development process for therapeutic and chemopreventative agents in colorectal cancer.
Dr. Chan works under the mentorship of Charles S. Fuchs, MD, MPH, and Ralph Weissleder, MD, PhD, at Massachusetts General Hospital, Boston, Massachusetts.
Rachael A. Clark, MD, PhD
Dr. Clark has made important findings on the role of immune T cells in skin cancers, particularly squamous cell carcinomas and cutaneous T cell lymphoma. The Continuation Grant will allow her to expand her research to Merkel cell carcinoma (MCC), a highly ma
|Contact: Yung S. Lie, Ph.D.|
Damon Runyon Cancer Research Foundation