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Damon Runyon Cancer Research Foundation awards $3.45 million to 9 top young clinical investigators
Date:6/21/2011

also donor T cells in the HCT graft that can cause a condition called "graft versus host disease" (GVHD). GVHD is a life-threatening immune response that remains the major barrier to the success of transplantation.

Dr. Bleakley focuses on developing new approaches to separate the beneficial GVL effect from detrimental GVHD after bone marrow transplantation. Her goal is to identify specific subsets of immune cells that promote GVHD; these cells can then be eliminated to reduce the frequency or severity of GVHD, while at the same time maintaining and improving the GVL effect. In addition, she aims to discover novel leukemia-associated proteins that could be potential targets for therapeutics.

Dr. Bleakley works under the mentorship of Stanley R. Riddell, MD, at the Fred Hutchinson Cancer Research Center, Seattle, Washington.

Ralph J. DeBerardinis, MD, PhD

Cancer cells use specific metabolic pathways to fuel their growth into tumors. A great deal of work has already defined some of these pathways that allow cancer cells to grow in the laboratory, but very little is known about which pathways drive the growth of actual tumors in cancer patients.

Dr. DeBerardinis aims to understand the role of metabolism in tumor growth and to use these findings to improve treatment of cancer. He plans to use novel, highly sensitive methods to study metabolic activity in vivo in primary human glioma brain tumors, and to image these activities in growing tumors. This approach should also be applicable to other cancer types and will be important for disease imaging and therapy.

Dr. DeBerardinis works under the mentorship of Helen H. Hobbs, MD, at the University of Texas Southwestern Medical Center, Dallas, Texas.

Joshua D. Schiffman, MD

Ewing's sarcoma is the second most common bone tumor in children and adolescents. Patients have a poor prognosis, yet the causes of the disease are not unde
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Contact: Yung S. Lie, Ph.D.
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

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