Damon Runyon Cancer Research Foundation awards $2.7M to 7 top young clinical inv...(ing donor T immune cell activity to prev...),Health

Date:6/30/2009

ing donor T immune cell activity to prevent acute graft-versus-host disease (GvHD) in cancer patients treated with bone marrow transplantation. His hypothesis is that regulatory T cells (Treg) can be used to suppress GvHD while preserving beneficial anti-tumor immunity. This work could have significant translational implications by reducing GvHD-associated mortality, thus improving the success of bone marrow transplantation in treatment of hematologic cancers such as leukemia and lymphoma.

Dr. Nguyen works under the mentorship of Thomas F. Gajewski, MD, PhD, at The University of Chicago, Chicago, Illinois.

2009 Clinical Investigator Continuation Grants

Renier J. Brentjens, MD, PhD [Lilly Investigator]

Dr. Brentjens is leading an innovative Phase I trial using patients' own genetically modified immune T cells to treat chronic lymphocytic leukemia (CLL). His Continuation Grant will be used to complete this trial, while also initiating a related clinical trial to treat pediatric patients with acute lymphocytic leukemia (ALL). These are patients for whom all other treatment options have been exhausted.

Dr. Brentjens works under the mentorship of Michel Sadelain, MD, PhD, at Memorial Sloan-Kettering Cancer Center, New York, New York.

Patrick A. Brown, MD [Lilly Investigator]

Dr. Brown is leading two national Phase I/II clinical trials focused on the first use of a small molecule inhibitor drug for the treatment of two types of pediatric leukemias, acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML). He is also developing a new test to predict patient response to this drug. The Continuation Grant will be used to complete these trials, which may lead to improved outcome for children with this disease.

Dr. Brown works under the mentorship of Donald Small, MD, PhD, at The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Andrea L. Cox,
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Contact: Yung S. Lie, Ph.D. yung.lie@damonrunyon.org 212-455-0521 Damon Runyon Cancer Research Foundation Source:Eurekalert

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