Damon Runyon Cancer Research Foundation awards $2.7M to 7 top young clinical inv...(es for TCL could greatly improve the out...),Health

Dr. Feldman works under the mentorship of Stephen M. Ansell, MD, PhD, and Ahmet Dogan, MD, PhD, at the Mayo Clinic, Rochester, Minnesota.

William Y. Kim, MD [Merck Investigator]

Bladder cancer is a prevalent and deadly disease, the fourth most common cancer in men. Dr. Kim is conducting a clinical trial examining the efficacy of erlotinib/Tarceva, an EGFR (epidermal growth factor receptor) inhibitor drug, in bladder cancer. His goal is to define predictors of patient response to erlotinib and other EGFR inhibitors and determine how to best coordinate EGFR inhibition with chemotherapy. These studies should have direct clinical impact on this deadly disease, allowing the treatment of patients most likely to benefit while minimizing unnecessary toxicity in those unlikely to respond.

Dr. Kim works under the mentorship of Charles M. Perou, PhD, at the University of North Carolina, Chapel Hill, North Carolina.

C. Ryan Miller, MD, PhD [Genentech Investigator]

The most common and deadly primary brain tumor is glioblastoma (GBM), which is comprised of a spectrum of disease subtypes that develop along distinct molecular pathways. Dr. Miller aims to use comparative analyses of GBM from both humans and mouse models 1) to develop diagnostic assays to classify human GBM, 2) to define new targets for preclinical drug development, and 3) to define the molecular changes in GBM after standard-of-care therapy. The ultimate goal of the research is to inform the next generation of clinical trials for patients with specific molecular subtypes of GBM.

Dr. Miller works under the mentorship of Charles M. Perou, PhD, and Terry Van Dyke, PhD, at the University of North Carolina, Chapel Hill, North Carolina.

Vu H. Nguyen, MD [August M. Watanabe, MD, Investigator]

Dr. Nguyen's goal is to develop novel ways of controll
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