Navigation Links
Daily Stress May Raise Women's Risk of Cervical Cancer
Date:2/15/2008

Researchers find chronic worry impairs immune response to cancer-causing virus

FRIDAY, Feb. 15 (HealthDay News) -- High levels of daily stress could explain why some women infected with malignancy-linked types of human papillomavirus (HPV) develop cervical cancer, a new study suggests.

Scientists at Fox Chase Cancer Center in Philadelphia tested 74 women, all diagnosed with cervical dysplasia (precancerous cervical lesions), for an immune response to HPV 16, one of the strains of human papillomavirus thought to be a major cause of cervical cancer. The women also completed a questionnaire that assessed stressful life events experienced during the previous six months -- including deaths of family members, loss of a job or divorce -- as well as their perceived daily stress level over the previous month.

The research, published in the February issue of Annals of Behavioral Medicine, found that slightly more than 55 percent of the women tested positive for one or more types of HPV, a sexually transmitted infection that can cause genital warts as well as cancer.

"We observed that stress was associated with deficits in immune response to HPV 16," said Carolyn Y. Fang, the study's lead investigator.

Most HPV infections in healthy women disappear over time without progressing to precancerous cervical lesions or cancer. "That means HPV infection alone is not sufficient to cause cervical cancer," Fang said. "Our study suggests a potential mechanism by which stress may influence cervical disease progression.

"We were surprised to discover no significant association between the occurrence of major stressful life events and immune response to HPV 16, possibly because of the amount of time that had passed since the event and how the women coped," she added. "However, women with higher perceived levels of daily stress were more likely to have an impaired immune response."

HPV expert Dr. Kevin Ault, associate professor of gynecology and obstetrics at Emory University School of Medicine in Atlanta, said, "It is unusual to see psychology and immunology in the same study, and this is very interesting. It is clear that almost all sexually active men and women get infected by HPV but very few have cancer. We already knew that nutrition may play a role. It seems likely that immune responses to HPV are influenced by stress, too."

Dr. Charles Raison, clinical director of Emory University's Mind-Body Program, said the new study adds to the growing evidence that stress can negatively influence health.

"There is data that stress can put the immune system at a disadvantage in dealing with viral infections. Even daily hassles like commuting in bad traffic can impact how the body functions," he said. "If a person with HPV is feeling stressed, it is important to do something positive to reduce the stress load. Exercise is known to help, and psychiatric therapy for any depression is important, too."

Fang added: "We want women to understand that stress does not cause cervical cancer, and feeling stressed out does not mean that one will develop cervical cancer. In this initial study, we observed that stress was associated with deficits in immune response to HPV. Whether stress causes these deficits, however, is unknown, and much more research will need to be done."

To that end, Fang and her research team have launched a five-year randomized trial to examine whether participation in an eight-week stress reduction program can lead to enhanced HPV-specific immune responses in women diagnosed with cervical dysplasia.

U.S. Centers for Disease Control and Prevention statistics show that one in four American women between the ages of 14 and 59 years is infected with HPV. Gardasil, a vaccine that protects against several cancer-causing HPV sub-types, has been approved by the U.S. Food and Drug Administration. However, the vaccine works best when given to girls before they become sexually active and is not effective in women already infected.

That means the best protection against cervical cancer for sexually active women, whether or not diagnosed with HPV, is to have regular Pap tests and to develop good health habits, Ault said.

More information

For more on HPV and cervical cancer, visit the CDC.



SOURCES: Carolyn Y. Fang, Ph.D., associate member, population science division, Fox Chase Cancer Center, Philadelphia; Charles Raison, M.D., clinical director, Mind-Body Program, department of psychiatry and behavioral sciences, Emory University School of Medicine, Atlanta; Kevin Ault, M.D., associate professor, department of gynecology and obstetrics, Emory University School of Medicine, Atlanta; February 2008 Annals of Behavioral Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Renuva Daily Balance Spray Is Designed to Be the Easiest and Best Way to Take Daily Vitamins and Minerals
2. Labopharms Once-Daily Tramadol Approved in South Korea and Australia
3. Labopharm Reports Positive Results for Phase III Study on Once-daily Trazodone
4. Research shows a daily does of beetroot juice can beat high blood pressure
5. FDA Approves ASMANEX (R) TWISTHALER(R) (Mometasone Furoate Inhalation Powder) for the Once Daily Maintenance Treatment of Asthma in Children Ages 4-11
6. Canadian Marketing and Sales Effort for Labopharms Once-Daily Tramadol Product to Expand Significantly
7. Los Angeles Daily Journal Names Richardson & Patel Verdict Top in the State of California for 2007
8. Labopharm enters into licensing and distribution agreement for once-daily tramadol in Australia with iNova
9. Daily exercise dramatically lowers mens death rates
10. Sickle Cell Disease Pain Can Occur Daily and Is Much More Severe Than Previously Thought
11. Join the Vitamin D Revolution: How to Get 30 Minutes of Daily Sunshine for Optimal Health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Daily Stress May Raise Women's Risk of Cervical Cancer 
(Date:4/26/2017)... (PRWEB) , ... April 26, 2017 , ... ... human performance, is proud to announce that it has received 510(k) clearance from ... the MyoCycle Home and the MyoCycle Pro. , Both devices are stationary cycling ...
(Date:4/25/2017)... (PRWEB) , ... April 25, ... ... based in Newport Beach, California, committed to raising awareness for Duchenne muscular ... results from its randomized CAP-1002 (cardiosphere-derived cells) Phase I/II HOPE clinical trial ...
(Date:4/25/2017)... BC (PRWEB) , ... April 25, 2017 , ... The ... from Richmond, BC, who live with dental fear and require sedation to receive dental ... at ease during various procedures, from hygienic cleanings to oral surgery, at their ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... unveiling cutting-edge birth defects research related to Zika virus during pregnancy, as well ... society for this important science. , The Teratology Society is ...
(Date:4/25/2017)... Clara, CA (PRWEB) , ... April 25, 2017 ... ... announces the addition of predictive analytics to its patient care management module. Using ... compliance even before a patient has been initiated on continuous positive airway pressure ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... VIEW, Calif. , April 19, 2017  IRIDEX ... it will release financial results for the first quarter ... 3, 2017.  The Company,s management team will host a ... 5:30 p.m. ET. Investors interested in listening ... (844) 707-0665 for domestic callers or (703) 326-3030 for ...
(Date:4/19/2017)... SAN DIEGO , April 19, 2017 /PRNewswire/ ... ("Sorrento"), an antibody-centric, clinical-stage biopharmaceutical company developing new ... today announced the closing of its previously announced ... common stock at a public offering price of ... commissions and estimated offering expenses payable by Sorrento.  ...
(Date:4/18/2017)... -- Cardinal Health (NYSE: CAH ) today is ... share (EPS) guidance and providing a preliminary view on ... this morning,s announcement of the planned acquisition of Medtronic,s ... Cardinal Health now believes that fiscal 2017 ... bottom of its previous guidance range of $5.35 to ...
Breaking Medicine Technology: