Daiichi Sankyo, Lilly Announce New Prasugrel Head-to-Head Phase III Study Against C... (to reopenblocked arteries). Currently mo...)

Daiichi Sankyo, Lilly Announce New Prasugrel Head-to-Head Phase III Study Against Clopidogrel

Date:11/4/2007

to reopen blocked arteries). Currently, more than 50 percent of patients presenting with ACS worldwide are managed without acute intervention.

"TRILOGY ACS, which will be one of the largest of its kind, will be a very important study as it will focus on a group of medically managed patients with ACS who have not been extensively studied in the past," said lead study investigator E. Magnus Ohman, M.D., Professor of Cardiology at Duke University School of Medicine.

When patients present with ACS, their symptoms are secondary to a lack of adequate oxygen delivery to the heart, usually due to a significant narrowing or blockage of one or more of the coronary arteries due to plaque. This plaque has the potential to rupture at any time and cause an arterial clot (thrombus) to form, which can block oxygenated blood from reaching the heart muscle. Antiplatelet medications help to reduce the incidence of this acute thrombus formation.

"The announcement of this study demonstrates our continued confidence in the clinical research surrounding prasugrel," said John Alexander, M.D., M.P.H., global head of research and development, Daiichi Sankyo Company, Limited.

About cardiovascular disease

Cardiovascular disease is the leading cause of death in the U.S. and worldwide, killing 16.7 million people each year(2). Acute heart attacks and unstable angina, called acute coronary syndrome, affect more than 840,000 Americans each year and 800,000 in Europe(3,4). Even with current medical interventions, 300,000 people experience recurrent heart attacks and 500,000 people die from heart attacks annually in the United States(5).

About prasugrel

Daiichi Sankyo Company, Limited (TSE: 4568), and Eli Lilly and Company (NYSE:

0

GOOD

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Daiichi Sankyo, Lilly Announce New Prasugrel Head-to-Head Phase III Study Against C...(to reopenblocked arteries). Currently mo...),Health