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Daiichi Sankyo, Inc. Announces Three Studies of Oral Factor Xa Inhibitor DU-176b Accepted for the 50th Annual Meeting of the American Society of Hematology
Date:12/2/2008

Results from Phase II Trial of DU-176b in Atrial Fibrillation Included in Scientific Program

EDISON, N.J., Dec. 2 /PRNewswire/ -- Daiichi Sankyo, Inc. (TSE: 4568), today announced that results from three studies of its investigational molecule, DU-176b, will be presented at the 50th Annual Meeting of the American Society of Hematology (ASH), to be held December 6 - 9, 2008, in San Francisco. The data accepted for the ASH meeting are part of the clinical development of DU-176b, an oral Factor Xa inhibitor being investigated to prevent the formation of blood clots. Information on the studies to be presented at the meeting is as follows:

  • Randomized, Parallel Group, Multicenter, Multinational Study Evaluating Safety of DU-176b Compared with Warfarin in Subjects with Non-Valvular Atrial Fibrillation (Abstract 33), by Jeffrey Weitz MD, FACP, FRCP, Henderson Research Centre, Hamilton, Ontario, Stuart J. Connolly, MD, FRCPC, Division of Cardiology, McMaster University, Hamilton, Ontario, Satoshi Kunitada, Daiichi Sankyo Pharma Development, Edison, New Jersey, James Jin, Daiichi Sankyo Pharma Development, Edison, New Jersey, Indravadan Patel, Daiichi Sankyo Pharma Development, Edison, New Jersey.This will be an oral presentation on Sunday, December 7, 2008.
  • Randomized, Double-Blind, Multi-Dose Efficacy, Safety and Biomarker Study of the Oral Factor Xa Inhibitor DU-176b Compared with Placebo for Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty (Abstract 34), by Takashi Fuji, MD, Department of Orthopaedic Surgery, Osaka Koseinenkin Hospital, Osaka, Japan, Satoru Fujita, MD, Department of Orthopaedic Surgery, Takarazuka Daiichi Hospital, Hyogo, Japan, Shintaro Tachibana, MD, Department of Orthopaedic Surgery, Toranomon Hospital, Tokyo, Japan and Yohko Kawai, MD, Sanno Hospital, Tokyo, Japan. This will be an oral presentation on Sunday, December 7, 2008.
  • Study of Coagulation and Platelets Response in an Open Label Randomized Non Treatment and Active Controlled (Dalteparin, Ximelagatran and DU-176b) in 4 Groups of Elderly Healthy Subjects (Abstract 3026), Professor Michel Meyer Samama, Biomnis, Ivry-sur-Seine cedex, France, Satoshi Kunitada, Daiichi Sankyo Pharma Development, Edison, New Jersey, A. Oursin, Biomnis, Ivry-sur-Seine cedex, France, Francois Depasse, Biomnis, Ivry-sur-Seine cedex, France and Nazneen Haque, Daiichi Sankyo Development Ltd., Gerald Cross, Buckinghamshire, United Kingdom. This will be a poster presentation on Monday, December 8, 2008.

To arrange an interview with Francis Plat, MD, vice president, clinical development at Daiichi Sankyo Pharma Development, or Jeffrey Weitz, MD, FACP, FRCP, Professor of Medicine and Biochemistry, McMaster University and Director, Henderson Research Centre, Hamilton, Ontario at the 2008 ASH Meeting in San Francisco, please contact Kim Wix, Daiichi Sankyo, at 973-695-8338 (office) 908-656-5447 (mobile) or Catherine Falcetti, MS&L, at 212-468-4337 (office) or 646-246-1843 (mobile).

About DU-176b

DU-176b is an oral anticoagulant that directly inhibits Factor Xa, a clotting factor in the blood. Daiichi Sankyo is developing DU-176b as a potential new treatment for the prevention of both arterial and venous thromboembolism.

About Daiichi Sankyo, Inc.

A global pharma innovator, Daiichi Sankyo Co., Ltd., was established in 2005 through the merger of two leading Japanese pharmaceutical companies. This integration created a more robust organization that allows for continuous development of novel drugs that enrich the quality of life for patients around the world. A central focus of Daiichi Sankyo's research and development is cardiovascular disease, including therapies for dyslipidemia, hypertension, diabetes, and acute coronary syndrome. Equally important to the company is the discovery of new medicines in the areas of cancer, infectious diseases, bone and joint diseases, and immune disorders. For more information, visit www.daiichisankyo.com.

Daiichi Sankyo, Inc., a subsidiary of the global research-based pharmaceutical company, is based in Parsippany, NJ.

    For more information, please contact:

    Kim Wix
    Daiichi Sankyo (U.S.A.)
    973-695-8338 (office)
    908-656-5447 (cell)


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SOURCE Daiichi Sankyo, Inc.
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