Navigation Links
Dads' Early-Onset Obesity Linked to Liver Disease in Kids
Date:4/3/2008

Genetic ties suspected between father's, but not mother's, weight and elevated enzymes

THURSDAY, April 3 (HealthDay News) -- People whose fathers had early-onset obesity are at increased risk for elevated liver enzyme levels and liver disease, says a U.S. study.

Researchers evaluated 1,732 children, average age 42, of participants in the Framingham Heart Study, a long-term study of families in Framingham, Mass. The researchers found that people whose fathers were clinically obese at an early age were more likely to have increased liver enzyme (serum alanine aminotransferase -- ALT) levels, an indicator of liver disease.

When the researchers conducted a secondary analysis that didn't include obese offspring, they still found a strong link between elevated serum ALT levels and paternal early-onset obesity. This demonstrates that the link between obesity in the father and elevated serum ALT levels in children is independent of the offspring's body-mass index (BMI) and persists among non-obese children, the researchers said.

No relationship was found between early-onset obesity in mothers and ALT levels in their children.

"These findings show that familial factors may play a role in elevated serum ALT levels in the general population," study senior author Dr. Caroline S. Fox, medical officer with the Framingham Heart Study, said in a prepared statement.

The study was published in the April issue of Gastroenterology.

Serum ALT levels are a marker of liver disease in the general population, and previous studies have shown that there's a strong link between obesity and elevated serum ALT levels, according to background information in the study.

Up to 7 percent of the adult U.S. population has unexplained elevated ALT serum levels, according to the U.S. National Health and Nutrition Examination Survey. These elevated ALT serum levels may be due to nonalcoholic fatty liver disease (NAFLD), which is believed to be the most common cause of elevated ALT serum levels, which can lead to inflammation of the liver (hepatitis), scarring of the liver (cirrhosis), and liver cancer.

"Serum ALT elevations and NAFLD are more prevalent than ever in the U.S., though we don't know specifically what's causing the increase. Our results point to a genetic connection between early-onset paternal obesity and increased ALT levels," Fox said.

"This study is the first to look at the connection between parental early-onset obesity and elevated serum ALT levels in their children using objective clinical measurements of parental BMI instead of self-reports," study first author Dr. Rohit Loomba, of the Liver Diseases Branch of the U.S. National Institute of Diabetes and Digestive and Kidney Diseases, said in a prepared statement.

"Though we are looking at a very specific, community-based sample in our work, the results suggest an association between elevated serum ALT levels and early-onset paternal obesity. Additional studies are needed to assess whether this connection suggests a genetic predisposition to developing liver disease in larger populations," Loomba said.

More information

The American Liver Foundation explains the progression of liver diseases.



-- Robert Preidt



SOURCE: American Gastroenterological Association, news release, April 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Dads Substance Use Hurts Expectant Moms Efforts to Quit
2. Some moms quit cigarettes, marijuana, alcohol during pregnancy, but dads dont
3. Dads break bones of children more often than moms
4. Having Lots of Kids Helps Dads Live to 100
5. Obesity During Pregnancy Carries Bigger Price Tag
6. Mayo Clinic Proceedings examines link between bacteria in the digestive system and obesity
7. Mayo Clinic Proceedings Examines a Possible Link Between Bacteria Found in the Human Digestive System and Obesity
8. Obesity Drug Shows Mixed Success Against Atherosclerosis
9. Normal weight obesity: An emerging risk factor for heart and metabolic problems
10. California Association of Health Plans & California Medical Association Foundation Team Up to Combat Obesity
11. EnergyNow! Announces New Grant Funding to Combat Childhood Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dads' Early-Onset Obesity Linked to Liver Disease in Kids
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/25/2017)... 2017   Montrium , an industry leader ... the IQPC Trial Master Files & Inspection Readiness ... EastHORN Clinical Services has selected eTMF Connect ... management. EastHORN, a leading European contract research organization ... transparency to enable greater collaboration with sponsors, improve ...
Breaking Medicine Technology: