DaVita Study Demonstrates Clinical Application of Sysmex Reticulocyte Hemoglobin Equivalent (RET-He)...( RET-He Parameter Demonstrates Potenti...),Health

RET-He Parameter Demonstrates Potential Value as an Indicator of Anemia Treatment Decisions for Physicians in ESRD patients on hemodialysis.

MUNDELEIN, Ill., June 10 /PRNewswire/ -- Sysmex America, Inc. today announced that a study titled "Day-to-Day, Week-to-Week, and Day-of-the-Week Variations in Tests of Anemia and Iron Status in Hemodialysis Patients" has identified Sysmex's Reticulocyte Hemoglobin Equivalent (RET-He) parameter result as key input used by physicians to assist in Anemia treatment decisions in ESRD patients on hemodialysis. David Van Wyck, M.D., Vice President of Clinical Affairs at DaVita Inc., and Emeritus Professor of Medicine and Surgery at the University of Arizona College of Medicine, in Tucson et. al followed five hematologic parameters in 30 patients undergoing hemodialysis three times a week. The patients were followed for 12 consecutive treatment days. The parameters studied were Hb, Hct, reticulocyte Hb (RET He or CHr), TSAT and ferritin levels.

The purpose of the DaVita(R) study was to evaluate the clinical value of these five parameters for supporting the physician's ability to make informed dosing decisions for ESA and IV iron therapy.

According to Dr. Van Wyck, "It has been difficult to know if the observed variability is within the 'expected ranges' for these patients or if changes in these markers signify a trend. Prior to this study, little information was available on expected day-to-day, within-patient variability among patients undergoing dialysis."

Over the course of the study, ESA doses were held constant and IV iron therapy was withheld. Same-sample analytic variability was measured, as was within-patient "biologic" variability. The number of sampling days needed to determine the true average value for each analyte was calculated with a 5% significance level and an 80% level of accuracy.

For all five paramete
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