Canadian dollars and a larger portion of the Company's revenue
stream is denominated in U.S dollars, the strengthening of the
Canadian dollar has a significant negative impact on the Company's
underlying gross profit margin and operating expenses. We estimate
the strengthening of the Canadian dollar has reduced operating
profitability by approximately 3 to 4 cents per share on an annual
basis relative to 2006.
- Volumes of radioactive products produced by the radiopharmaceutical
operations were lower than expected for the second half of 2007 due
to a decision by a customer to cease production of a private label
radioactive product (which historically represented $350,000 in
revenues per quarter) while the customer determines whether to
continue to supply the market in the future pending possible
formulation changes.
- During the course of 2007, two separate shortages for the supply of
radioactive isotopes occurred which impacted the financial
performance of the radiopharmaceutical segment. The first shortage
resulted in the Company obtaining the approval of a secondary source
of supply for the U.S. market. The second shortage created an
industry wide decrease in demand in late 2007 for radioactive
procedures due to a short supply in the market place of
radioisotopes, being the key ingredient.
- Hectorol(R) production volumes in 2007 were $9 million lower than
what they were in 2006 and significantly lower than what was
originally forecasted for 2007. It is our understanding that these
volumes may still vary materially either positively or negatively in
future quarters as a result of continued uncertainty in custome
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