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DNDi receives the BBVA Foundation Frontiers of Knowledge Award in Development Cooperation
Date:6/19/2013

e Barcelona Centre for International Health Research (CRESIB), Carlos III University of Madrid, and GSK Tres Cantos. DNDi has also received financial support from the Spanish development cooperation agency AECID.

Six approved treatments

Pcoul offers figures to illustrate just what is meant by neglected diseases: between 1975 and 1999 only 16 of the total 1,393 new drugs developed by the pharmaceutical industry were specifically developed for neglected tropical diseases plus malaria or tuberculosis. In the last decade "progress has been made," but, he is quick to point out, "the fatal imbalance persists." Only 3.8% of the products, excluding vaccines, approved between 2000 and 2011 were targeted for neglected diseases, as was the case for only 1.4% of all clinical trials conducted in the same period.

After ten years of research and development, DNDi has delivered six treatments: two antimalarials, a combination therapy for late-stage sleeping sickness, a combination therapy for visceral leishmaniasis in Africa, a set of combination therapies for visceral leishmaniasis in Asia, and a pediatric dosage form of benznidazole for Chagas disease.

Also, the organization has helped establish three clinical research platforms in Africa and the Americas: for leishmaniasis in Kenya, Ethiopia, Sudan, and Uganda; for sleeping sickness in the Democratic Republic of the Congo and other endemic countries in the region; and for Chagas disease in Latin America. "Strong regional networks such as these," Pcoul affirms, "help strengthen research and treatment implementation capacity in neglected disease-endemic countries."

Sleeping sickness

NECT, the new sleeping sickness treatment developed by DNDi and its partners, is the first new product in 25 years for the late stage of the disease. It is far safer than what had previously been standard treatment, melarsoprol, an arsenic derivative so toxic that it kills 5% of thos
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Contact: Violaine Dällenbach
vdallenbach@dndi.org
41-794-241-474
Drugs for Neglected Diseases Initiative
Source:Eurekalert

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