Navigation Links
DNDi expands activities to neglected patient needs in the field of helminth infections

Geneva/Boston (July 8, 2011) -- Today at the Neglected Tropical Diseases Meeting of the International Society for Infectious Diseases (ISID-NTD) in Boston, the Drugs for Neglected Diseases initiative (DNDi) announced the first research and development project in its new helminth infection drug portfolio to address unmet needs of patients in Africa and Asia.

The project will assess the potential of the drug flubendazole to treat a highly neglected subset of helminth infections, notably co-infection of two of the three filarial diseases: onchocerciasis (river blindness) and lymphatic filariasis (LF; elephantiasis), in co-infection with loiasis (African eyeworm or Loa loa). Existing treatments are inadequate and in some cases life-threatening.

The project is supported by a grant from The Bill & Melinda Gates Foundation.

While remaining fully committed to kinetoplastid diseases (sleeping sickness, leishmaniases, and Chagas disease) DNDi is expanding its drug portfolio to include helminth infections, focusing specifically on filariasis, because in patients co-infected with filariasis and loa loa, the standard treatment of ivermectin, alone or in combination with albendazole, can result in brain dysfunction, coma, and potentially death.

The objective is to assess and reformulate flubendazole, which has proven highly active against adult filarial worms in animals and humans, into a safe, highly efficacious, and field-adapted macrofilaricidal drug candidate.

If successful, flubendazole would be highly useful for case management and in mass drug administration (MDA) programs to treat, control, and eliminate filarial infections, regardless of parasitic worm life stage. Current drugs primarily kill young worms whereas a macrofilaricide would kill adult worms.

"DNDi is focusing on developing a safe macrofilaricide to kill the adult worms with no severe adverse reactions," said Dr Shing Chang, Director of R&D at DNDi. "Such a drug could be used as an alternative preventive treatment with a major public health impact."

In addition to addressing the specific and urgent needs of co-infected patients, a new macrofilaricide could significantly reduce treatment cycles even for areas that are not burdened by co-infection, since it would no longer be necessary to wait until the adult worm dies, which can take up to 12 years. It could reduce current the MDA treatment cycle to approximately 2 to 3 years, making the diseases easier to control.

"The first step of this project is to assess the safety profile in pre-clinical studies to further reformulate flubendazole and develop a safe, highly efficacious, and field-adapted macrofilaricidal drug candidate," explains Dr. Charles MacKenzie of Michigan State University, who was involved in early work on flubendazole. "Flubendazole is the only macrofilaricide candidate on the horizon that has demonstrated positive in vivo results."

DNDi is partnering with Michigan State University in the US, and McGill University in Canada, for the pharmacodynamic studies; the generic pharmaceutical company Advinus Therapeutics, in India, for the toxicology and the pharmacokinetics studies; and Drugabilis and Bertin Pharma, France, for the pre-formulation and formulation of the drug, respectively.

"Without new tools adapted to the needs of patients in the poorest and remote areas of the world it will be difficult, if not impossible, to eliminate some of the most common neglected tropical diseases," said Dr. Bernard Pcoul, Executive Director of DNDi. "To achieve sustainable control and potential elimination of helminth infections, we need to both improve implementation of existing tools and develop better drugs for patients in whom current treatments do not work."

The initial investigations by DNDi to assess its helminth drug portfolio were made possible with the financial support of Doctors Without Borders/Mdecins Sans Frontires.


Contact: Oliver Yun
Drugs for Neglected Diseases Initiative

Related medicine news :

1. National High Value Healthcare Collaborative expands
2. Brazils health care system vastly expands coverage, but universality, equity remain elusive
3. Brachytherapy, the official journal of ABS, expands to 6 issues in 2011
4. Deep brain stimulation research expands at Barrow
5. Overabundance of protein expands breast cancer stem cells
6. Autism Speaks Autism Treatment Network expands to 17 sites in North America
7. NIH expands food allergy research program
8. Microfluidics Expands Partnership with Particle Sciences to Include Continuous Crystallization Capabilities
9. DNV Healthcare Inc. Expands to New Administrative Headquarters for US Hospital Accreditation Services
10. MISI Company, Ltd. Acquires Cue Data Services and Expands Geographically to New England and Canada
11. Brilliance Weight Loss Expands Business
Post Your Comments:
(Date:11/30/2015)... ... 2015 , ... Live Very Well is excited to announce ... . The multi-carrier insurance exchange platform offers individual vision and dental ... compare, quote and match plans to meet their needs. , Beginning December ...
(Date:11/30/2015)... ... November 30, 2015 , ... Until now, the St. ... in the MOMS (Management of Myelomeningocele Study) trial. One of these exclusion criteria was ... a BMI of 18.5 to 24.9 is considered normal, 25 - 29.9 is overweight ...
(Date:11/30/2015)... ... 30, 2015 , ... Stress, anxiety, illness, infection or even a need for ... , Heather Spader, MD, a new pediatric neurosurgeon at Joe DiMaggio Children’s Hospital in ... to tumors. , “Bad headaches that don’t go away, that don’t have ...
(Date:11/30/2015)... ... November 30, 2015 , ... Thermi™, a ... to announce that its ThermiRFR temperature controlled radiofrequency platform has received CE marking ... radiofrequency platform which uses temperature as a clinical endpoint. The technology has ...
(Date:11/30/2015)... ... 30, 2015 , ... MOSI recently added two state-of-the-art augmented reality (AR) experiences ... Jurassic to their collection of interactive exhibits within the Kids In Charge! building. In ... guests to get closer than ever to a range of animals as they drink, ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015   Royal Philips (NYSE: ... industry,s first MRI guided user interface and automatic scan ... with MR Conditional implants, such as knee and hip ... Radiological Society of North America Annual Meeting (RSNA) . ... diagnostic confidence of this growing patient population. ScanWise Implant ...
(Date:11/30/2015)... India , November 30, 2015 ... 2014, and is expected to grow at a CAGR of 7.6% ... was valued at USD 135.6 million in 2014, and is ... 2020. --> According to the new Market Research Report ... invasive, non-invasive), By End User (Hospitals, ambulatory care, others) - Analysis ...
(Date:11/30/2015)... 2015 2014RestatedChange%Turnover 545,575 , 518,852 , 5.2 Cord Blood ... , 9.8 Hospital Management Service Income , ... Medical Insurance Administration Service Income , 2,780 , ... , 89,645 , 94,580 , ... 2,917 , (3.3) Gross Profit 395,857 , ...
Breaking Medicine Technology: