Navigation Links
DNDi expands activities to neglected patient needs in the field of helminth infections
Date:7/8/2011

Geneva/Boston (July 8, 2011) -- Today at the Neglected Tropical Diseases Meeting of the International Society for Infectious Diseases (ISID-NTD) in Boston, the Drugs for Neglected Diseases initiative (DNDi) announced the first research and development project in its new helminth infection drug portfolio to address unmet needs of patients in Africa and Asia.

The project will assess the potential of the drug flubendazole to treat a highly neglected subset of helminth infections, notably co-infection of two of the three filarial diseases: onchocerciasis (river blindness) and lymphatic filariasis (LF; elephantiasis), in co-infection with loiasis (African eyeworm or Loa loa). Existing treatments are inadequate and in some cases life-threatening.

The project is supported by a grant from The Bill & Melinda Gates Foundation.

While remaining fully committed to kinetoplastid diseases (sleeping sickness, leishmaniases, and Chagas disease) DNDi is expanding its drug portfolio to include helminth infections, focusing specifically on filariasis, because in patients co-infected with filariasis and loa loa, the standard treatment of ivermectin, alone or in combination with albendazole, can result in brain dysfunction, coma, and potentially death.

The objective is to assess and reformulate flubendazole, which has proven highly active against adult filarial worms in animals and humans, into a safe, highly efficacious, and field-adapted macrofilaricidal drug candidate.

If successful, flubendazole would be highly useful for case management and in mass drug administration (MDA) programs to treat, control, and eliminate filarial infections, regardless of parasitic worm life stage. Current drugs primarily kill young worms whereas a macrofilaricide would kill adult worms.

"DNDi is focusing on developing a safe macrofilaricide to kill the adult worms with no severe adverse reactions," said Dr Shing Chang, Director of R&D at DND
'/>"/>

Contact: Oliver Yun
oyun@dndi.org
646-266-5216
Drugs for Neglected Diseases Initiative
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. National High Value Healthcare Collaborative expands
2. Brazils health care system vastly expands coverage, but universality, equity remain elusive
3. Brachytherapy, the official journal of ABS, expands to 6 issues in 2011
4. Deep brain stimulation research expands at Barrow
5. Overabundance of protein expands breast cancer stem cells
6. Autism Speaks Autism Treatment Network expands to 17 sites in North America
7. NIH expands food allergy research program
8. Microfluidics Expands Partnership with Particle Sciences to Include Continuous Crystallization Capabilities
9. DNV Healthcare Inc. Expands to New Administrative Headquarters for US Hospital Accreditation Services
10. MISI Company, Ltd. Acquires Cue Data Services and Expands Geographically to New England and Canada
11. Brilliance Weight Loss Expands Business
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... The need for larger space has become more pressing ... new location - 4700 Bryant Irvin Court, Fort Worth, TX ... than TLC had in the past, as well as new ... new location because it represents a good fit for our ... size compared to the current one, the building itself is ...
(Date:8/28/2014)... The next episode of “Extreme Weight Loss” ... He’s a drama coach who longs to audition for ... achieving that dream impossible. , Featuring a unique, non-competitive ... Tuesday, September 2 (9:00-11:00 p.m., ET/PT) on the ABC ... smile on the outside to hide the self-doubt and ...
(Date:8/27/2014)... (PRWEB) August 28, 2014 A St. ... Danis & Lowe reports that the C.R. Bard ... thousands of consolidated transvaginal mesh lawsuits, recently filed a ... #136 pertains to the pretrial discovery process, and more ... sensitive evidence. , Carey Danis & Lowe is a ...
(Date:8/27/2014)... Texas (PRWEB) August 28, 2014 Spine ... prominent online source of information on spinal health. Now, ... back pain, or people suffering from back pain symptoms. ... sciatica surgery, cervical/neck surgery, and lumbar spine surgery. , ... muscle ache, shooting or stabbing pain, pain radiating down ...
(Date:8/27/2014)... DiaSorin has announced that their new ... will feature guest speaker Dr. Gregory A. Plotnikoff, a ... and Healing Integrative Medicine. Dr. Plotnikoff serves as an ... Health and Healing and as Senior Consultant, Center for ... also serves as a co-editor of the new journal ...
Breaking Medicine News(10 mins):Health News:“Extreme Weight Loss”: Rod’s Journey Begins at the University of Colorado Anschutz Health and Wellness Center 2Health News:Carey Danis & Lowe Reports On New Court Order in C.R. Bard Transvaginal Mesh MDL 2Health News:Spine Guide Offering New Overview of Surgical Options For Back Pain 2Health News:DiaSorin Announces New Webinar in Their Annual Vitamin D Series 2Health News:DiaSorin Announces New Webinar in Their Annual Vitamin D Series 3
... help people with Parkinson,s disease improve their gait and balance, ... School of Nursing and Red Hill Studios, a California serious ... three-month research project showed small improvements in walking speed, balance ... the first research team in the United States to receive ...
... investigators from the throughout the Middle East gathered today ... Foundation,s (IOF) 1st Middle-East and Africa Osteoporosis Meeting. ... Dubai Festival City to October 22, 2011,has received the ... Al Maktoum, Deputy Ruler of Dubai, U.A.E. Minister of ...
... HOUSTON -- (Oct. 19, 2011) -- A review of ... a possible link between the widely diagnosed neurological disorder ... rise in recent decades. "It appears that both ... mechanism -- impaired glucose tolerance and hyperinsulinemia," said Rice ...
... older are diagnosed with late-stage and more aggressive prostate cancer ... men, according to a University of Rochester analysis published online ... study is particularly relevant in light of the recent controversy ... panel said that healthy men age 50 and older should ...
... News) -- Men who get moderate amounts of exercise have ... physically active, a new study finds. Motility refers to ... an important factor in fertility. The study by researchers ... semen samples and information about their physical activity levels. The ...
... By Kathleen Doheny HealthDay Reporter , WEDNESDAY, Oct. ... they undergo anesthesia, two new studies suggest. In one ... complications from anesthesia than normal weight children with asthma. ... less of one type of anesthesia than normal weight kids. ...
Cached Medicine News:Health News:Computer games help people with Parkinson's disease 2Health News:1st Middle East and Africa Osteoporosis Meeting opens in Dubai 2Health News:Research proposes common link between autism, diabetes 2Health News:Research proposes common link between autism, diabetes 3Health News:Rochester study: Age a big factor in prostate cancer deaths 2Health News:Sperm Moves Best for Moderate Exercisers: Study 2Health News:Obese, Asthmatic Kids Need Special Care Under Anesthesia 2Health News:Obese, Asthmatic Kids Need Special Care Under Anesthesia 3
(Date:8/27/2014)... North American lighting leader OSRAM SYLVANIA has been ... OSRAM ITOS ® PHASER ® 3000, the industry,s ... and surgical head lamps that delivers the same brightness as ... "We,re honored to be recognized by R&D ... of the past year," said Andreas Osten , medical ...
(Date:8/27/2014)...  CVS Caremark (NYSE: CVS ) announced ... with MedStar Health, a leading health care system with ... the Washington, DC , region, which ... for patients. Through this clinical affiliation, MedStar Health patients ... counseling, chronic disease monitoring and wellness programs at CVS/pharmacy ...
(Date:8/27/2014)... LYNDHURST N.J. and NINGBO, China ... ("Amerigen") and the Ningbo Menovo Pharmaceutical Co., Ltd, ("Menovo") ... regarding the development of generic pharmaceuticals, primarily targeting ... terms of the agreement, Amerigen and Menovo will jointly ... the United States . Menovo will be responsible ...
Breaking Medicine Technology:OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 3CVS Caremark Announces New Clinical Affiliation with MedStar Health 2CVS Caremark Announces New Clinical Affiliation with MedStar Health 3Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2
... LOUIS, Oct. 14 Young Innovations, Inc. (Nasdaq: YDNT ) ... with a live and on-demand web cast conference call on Thursday, ... audio broadcast of the call will be available through InterCall at ... audio broadcast will also be available through the Company,s website, ...
... Oct. 14 In the United States, a woman is ... American Cancer Society. Except for skin cancers, breast cancer ... , To help fight this disease, eMed-ID, the ... for every pink Personal Health Records (PHR) wristband sold to ...
Cached Medicine Technology:Young Innovations, Inc. Provides Third Quarter Conference Call Details 2Breast Cancer Survivors and Patients Encouraged to Have Medical History Readily Available 2Breast Cancer Survivors and Patients Encouraged to Have Medical History Readily Available 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: