Navigation Links
DNDi expands activities to neglected patient needs in the field of helminth infections
Date:7/8/2011

Geneva/Boston (July 8, 2011) -- Today at the Neglected Tropical Diseases Meeting of the International Society for Infectious Diseases (ISID-NTD) in Boston, the Drugs for Neglected Diseases initiative (DNDi) announced the first research and development project in its new helminth infection drug portfolio to address unmet needs of patients in Africa and Asia.

The project will assess the potential of the drug flubendazole to treat a highly neglected subset of helminth infections, notably co-infection of two of the three filarial diseases: onchocerciasis (river blindness) and lymphatic filariasis (LF; elephantiasis), in co-infection with loiasis (African eyeworm or Loa loa). Existing treatments are inadequate and in some cases life-threatening.

The project is supported by a grant from The Bill & Melinda Gates Foundation.

While remaining fully committed to kinetoplastid diseases (sleeping sickness, leishmaniases, and Chagas disease) DNDi is expanding its drug portfolio to include helminth infections, focusing specifically on filariasis, because in patients co-infected with filariasis and loa loa, the standard treatment of ivermectin, alone or in combination with albendazole, can result in brain dysfunction, coma, and potentially death.

The objective is to assess and reformulate flubendazole, which has proven highly active against adult filarial worms in animals and humans, into a safe, highly efficacious, and field-adapted macrofilaricidal drug candidate.

If successful, flubendazole would be highly useful for case management and in mass drug administration (MDA) programs to treat, control, and eliminate filarial infections, regardless of parasitic worm life stage. Current drugs primarily kill young worms whereas a macrofilaricide would kill adult worms.

"DNDi is focusing on developing a safe macrofilaricide to kill the adult worms with no severe adverse reactions," said Dr Shing Chang, Director of R&D at DNDi. "Such a drug could be used as an alternative preventive treatment with a major public health impact."

In addition to addressing the specific and urgent needs of co-infected patients, a new macrofilaricide could significantly reduce treatment cycles even for areas that are not burdened by co-infection, since it would no longer be necessary to wait until the adult worm dies, which can take up to 12 years. It could reduce current the MDA treatment cycle to approximately 2 to 3 years, making the diseases easier to control.

"The first step of this project is to assess the safety profile in pre-clinical studies to further reformulate flubendazole and develop a safe, highly efficacious, and field-adapted macrofilaricidal drug candidate," explains Dr. Charles MacKenzie of Michigan State University, who was involved in early work on flubendazole. "Flubendazole is the only macrofilaricide candidate on the horizon that has demonstrated positive in vivo results."

DNDi is partnering with Michigan State University in the US, and McGill University in Canada, for the pharmacodynamic studies; the generic pharmaceutical company Advinus Therapeutics, in India, for the toxicology and the pharmacokinetics studies; and Drugabilis and Bertin Pharma, France, for the pre-formulation and formulation of the drug, respectively.

"Without new tools adapted to the needs of patients in the poorest and remote areas of the world it will be difficult, if not impossible, to eliminate some of the most common neglected tropical diseases," said Dr. Bernard Pcoul, Executive Director of DNDi. "To achieve sustainable control and potential elimination of helminth infections, we need to both improve implementation of existing tools and develop better drugs for patients in whom current treatments do not work."

The initial investigations by DNDi to assess its helminth drug portfolio were made possible with the financial support of Doctors Without Borders/Mdecins Sans Frontires.


'/>"/>

Contact: Oliver Yun
oyun@dndi.org
646-266-5216
Drugs for Neglected Diseases Initiative
Source:Eurekalert

Related medicine news :

1. National High Value Healthcare Collaborative expands
2. Brazils health care system vastly expands coverage, but universality, equity remain elusive
3. Brachytherapy, the official journal of ABS, expands to 6 issues in 2011
4. Deep brain stimulation research expands at Barrow
5. Overabundance of protein expands breast cancer stem cells
6. Autism Speaks Autism Treatment Network expands to 17 sites in North America
7. NIH expands food allergy research program
8. Microfluidics Expands Partnership with Particle Sciences to Include Continuous Crystallization Capabilities
9. DNV Healthcare Inc. Expands to New Administrative Headquarters for US Hospital Accreditation Services
10. MISI Company, Ltd. Acquires Cue Data Services and Expands Geographically to New England and Canada
11. Brilliance Weight Loss Expands Business
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, ... -based mobile pulmonary function testing company, is now able to perform ... developed by ndd Medical Technologies , Inc. ... in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL ... can get any needed testing done in the comfort of her ...
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
Breaking Medicine Technology: