Navigation Links
DNDi expands activities to neglected patient needs in the field of helminth infections
Date:7/8/2011

Geneva/Boston (July 8, 2011) -- Today at the Neglected Tropical Diseases Meeting of the International Society for Infectious Diseases (ISID-NTD) in Boston, the Drugs for Neglected Diseases initiative (DNDi) announced the first research and development project in its new helminth infection drug portfolio to address unmet needs of patients in Africa and Asia.

The project will assess the potential of the drug flubendazole to treat a highly neglected subset of helminth infections, notably co-infection of two of the three filarial diseases: onchocerciasis (river blindness) and lymphatic filariasis (LF; elephantiasis), in co-infection with loiasis (African eyeworm or Loa loa). Existing treatments are inadequate and in some cases life-threatening.

The project is supported by a grant from The Bill & Melinda Gates Foundation.

While remaining fully committed to kinetoplastid diseases (sleeping sickness, leishmaniases, and Chagas disease) DNDi is expanding its drug portfolio to include helminth infections, focusing specifically on filariasis, because in patients co-infected with filariasis and loa loa, the standard treatment of ivermectin, alone or in combination with albendazole, can result in brain dysfunction, coma, and potentially death.

The objective is to assess and reformulate flubendazole, which has proven highly active against adult filarial worms in animals and humans, into a safe, highly efficacious, and field-adapted macrofilaricidal drug candidate.

If successful, flubendazole would be highly useful for case management and in mass drug administration (MDA) programs to treat, control, and eliminate filarial infections, regardless of parasitic worm life stage. Current drugs primarily kill young worms whereas a macrofilaricide would kill adult worms.

"DNDi is focusing on developing a safe macrofilaricide to kill the adult worms with no severe adverse reactions," said Dr Shing Chang, Director of R&D at DND
'/>"/>

Contact: Oliver Yun
oyun@dndi.org
646-266-5216
Drugs for Neglected Diseases Initiative
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. National High Value Healthcare Collaborative expands
2. Brazils health care system vastly expands coverage, but universality, equity remain elusive
3. Brachytherapy, the official journal of ABS, expands to 6 issues in 2011
4. Deep brain stimulation research expands at Barrow
5. Overabundance of protein expands breast cancer stem cells
6. Autism Speaks Autism Treatment Network expands to 17 sites in North America
7. NIH expands food allergy research program
8. Microfluidics Expands Partnership with Particle Sciences to Include Continuous Crystallization Capabilities
9. DNV Healthcare Inc. Expands to New Administrative Headquarters for US Hospital Accreditation Services
10. MISI Company, Ltd. Acquires Cue Data Services and Expands Geographically to New England and Canada
11. Brilliance Weight Loss Expands Business
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 2014 The short film “Color of Honor” ... honor of a true 9/11 hero, Welles Remy Crowther. It ... the 24 hours of Nuremberg International Short Film Festival and ... Actress, screenwriter and director Luciana Lagana plays the ... with her husband, Gregory Graham - Graham plays ...
(Date:12/25/2014)... When head lice hits a home or school, ... get rid of it while keeping it from taking over ... have the solution right in their neighborhood: Lice Troopers ... provides full spectrum head lice screening and treatment services to ... Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. ...
(Date:12/25/2014)... (HealthDay News) -- Overeating is common during the holidays, but ... an expert says. "Don,t arrive at a party hungry. ... know you,ll be attending a party, but deprivation leads to ... at Northern Westchester Hospital in Mount Kisco, N.Y., said in ... during the day and even to have a snack before ...
(Date:12/25/2014)... 2014 Thousands of transvaginal mesh lawsuits ... a number of multidistrict litigations currently underway in U.S. ... LLP reports. According to an Order issued on December ... Joint Status Conference in all of the proceedings on ... directed to submit a proposed agenda to the Court ...
(Date:12/25/2014)... Rosa, CA (PRWEB) December 25, 2014 ... department visits and 2 million hospital admissions across the ... and Prevention ). The CDC’s National Hospital Ambulatory ... departments through a survey conducted in 2010. They estimated ... department visits that resulted in a primary diagnosis of ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... ... major business industries choose Extended Validation SSL to increase trust and confidence in online ... London, ... longest established Certification Authorities (CA) and specialists in SSL Certificate security, has today announced ...
... ... provide Aprima EHR/PM solutions to Missouri and Kansas medical practitioners , ... DALLAS, TX (Vocus) March 23, 2010 ... practice management (PM) and revenue cycle management solutions for medical practices, today announced a ...
... ... month by donating book sets aimed at combatting child sex abuse. , ... Boston, MA (PRWEB) March 24, 2010 -- On ... to the first 50 people who place an order at www.endchildmolestation.com . The ...
... ... has launched StrengthofUs.org, a new online community where young adults living with mental health concerns ... from ages 18 to 25. , ... Arlington, VA (PRWEB) March 23, 2010 -- The National Alliance on Mental Illness ...
... March 23 "Democrats defending the new Obama health law claim that a woman,s right to abortion is protected. That,s not possible ... New York State.  "Either your body is protected from government interference or it isn,t." , ... ... ...
... assist seniors with aging at home, announced this week a recent expansion of its site,s resources and content. , ... , , ... ... ...
Cached Medicine News:Health News:GlobalSign EV SSL Certificates Secure Leading World Wide Brands 2Health News:GlobalSign EV SSL Certificates Secure Leading World Wide Brands 3Health News:GlobalSign EV SSL Certificates Secure Leading World Wide Brands 4Health News:Aprima and CyTek Corporation Partner to Provide Electronic Health Records to Physician Practices, 2Health News:Author Donates Books To End Child Molestation 2Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 2Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 3Health News:Betsy McCaughey: Government Control of Your Body 2Health News:Interactive Web Site Provides Resources So Seniors May Age in Place 2Health News:Interactive Web Site Provides Resources So Seniors May Age in Place 3Health News:Interactive Web Site Provides Resources So Seniors May Age in Place 4
(Date:12/24/2014)... -- Lockton Dunning Benefits, the Dallas ... of Vice President Kim Foerster on ... team, Excelsior Solutions. Foerster brings ... position.  Most recently, she worked as the Director ... where she has held various managerial positions since ...
(Date:12/24/2014)... HILL, N.C. , Dec. 23, 2014  Medical ... success. As the key link between the medical device ... grow even more in the coming years as the ... According to research by benchmarking firm, ... MSLs can gain an important edge is by harnessing ...
(Date:12/22/2014)... , Dec. 22, 2014   TRU-D SmartUVC ... UV disinfection robot, announced today that the General Services ... through November 2019.   This newly formed ... all levels of government purchasers, including Department of Veteran ... as Homeland Security contacts purchasing solutions for the Ebola ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2Role of Medical Science Liaisons Evolving in Medical Device Sector 2TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... 2011 /PRNewswire-iReach/ --  Janet R. Dees, CEO/President of ... opening of its newest vascular access center in Columbus, ... success for American Vascular Access, LLC., and the addition ... R. Dees, CEO/President.   "Our goal has continued ...
... Holdings, Inc. (NYSE: ZMH ; SIX: ZMH), a ... of its CLS® Brevius ™ Hip Stem with ... new technology enables surgeons to better match patients, individual ... adjustments. "Following its introduction in Europe earlier ...
Cached Medicine Technology:American Vascular Access Continues Growth in Georgia 2Zimmer Introduces New CLS® Brevius™ Hip Stem with Kinectiv® Technology in the United States 2Zimmer Introduces New CLS® Brevius™ Hip Stem with Kinectiv® Technology in the United States 3
... Siemens introduces the AXIOM Artis ... first biplane magnetic navigation system equipped ... both planes, which is uniquely capable ... of catheter-based procedures to facilitate increased ...
... AXIOM Artis dTC is a versatile ... the cardiology department from preparation to ... interventional procedures. With AXIOM Artis dTC, your ... the cardiology department that leaves you free ...
The AXIOM Artis TC is ideal for applications above and beyond standard cardioangiography, and features:, Single plane C-Arm, ceiling-mounted, Full-size CCD camera, ...
... AXIOM Artis BC is a ... system architecture ideal for cardiological ... and ergonomic architecture enables you ... configuration to focus on:, ...
Medicine Products: