Navigation Links
DNA-repairing protein may be key to preventing recurrence of some cancers
Date:1/28/2013

Just as the body can become resistant to antibiotics, certain methods of killing cancer tumors can end up creating resistant tumor cells. But a University of Central Florida professor has found a protein present in several types of cancer, including breast and ovarian cancer, which could be helpful in preventing tumors from coming back.

The protein, KLF8, appears to protect tumor cells from drugs aimed at killing them and even aid the tumor cells' ability to regenerate.

"All cells have a DNA-repair mechanism," explained Jihe Zhao, a medical doctor and researcher who in the past few months has published several articles related to the protein in the Journal of Biological Chemistry (http://www.jbc.org/content/287/52/43720) and Oncogene (http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2012545a.html), among others. "That's why we survive constant DNA damage threats. But KLF8 is overexpressed in specific cancers, such as breast cancer and ovarian cancer. The thought is that if we can stop it from switching on, we may be able to stop the tumors from coming back as part of therapy. We still need to do a lot more research, but it is plausible."

There are between 2.5 million and 2.7 million women who have breast cancer in the United States and 10 to 20 percent will experience a recurrence, according to the American Cancer Society. Current treatment options, depending on the stage of cancer, include surgical removal followed by chemotherapy using a combination of cancer killing drugs. Each year about 22,200 women are also diagnosed with ovarian cancer.

DNA damage-based chemotherapies depend on failure of cancer cells to repair the DNA damage and subsequent cell death, according to the journal article. Aberrant high levels of DNA repair function in the cells likely increase not only the resistance of the cells to such therapies but also the malignancy of the cells due to improper DNA repair-mediated genomic and chromosomal instability.

In the study, Zhao's team tested one specific cancer-fighting drug used in the treatment of breast cancer to determine the role of the protein.

"Indeed, our results have clearly linked the KLF8-promoted DNA repair to the cell resistance to doxorubicin-induced cell death," Zhao said. "It remains to be determined whether KLF8 plays a similar role in repairing DNA damage caused by other types of genotoxic agents such as DNA alkylating agents and ionizing radiation."

Even so, the results suggest that in addition to enhancing the drug resistance of the cancer cells, KLF8 could play a role in disturbing genomic integrity through its aberrant DNA repair function and subsequently contribute to aggressive progression of cancer.


'/>"/>
Contact: Zenaida Kotala
zenaida.kotala@ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Related medicine news :

1. A blend of soy and dairy proteins promotes muscle protein synthesis when consumed after exercise
2. UT MD Anderson scientists find protein that reins in runaway network
3. Lack of protein Sp2 disrupts neuron creation in brain
4. Protein identified that can disrupt embryonic brain development and neuron migration
5. Dr. Harvey’s Launches "Oracle": a Revolutionary Freeze-Dried, Highly Nutritious and Protein-Rich Line of Complete Foods for Dogs and Cats
6. Protein recognition and disorder: A debate
7. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
8. U-M sibling study discovers genetic region linked to control of key blood-clotting protein
9. New Greens and Protein Powders Help Supply Essential Nutrients
10. Strange behavior: New study exposes living cells to synthetic protein
11. Blood Protein Linked to Depression, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA-repairing protein may be key to preventing recurrence of some cancers
(Date:2/8/2016)... ... February 08, 2016 , ... Stephanie Hebert Insurance Agency, ... of a new charity campaign. As part of their ongoing community involvement program, ... the belief that children deserve a voice, and in the spirit of neighbors ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... A man who has struggled to quit ... Freedom Laser Therapy , was determined to find solutions to his problems – and he ... Inventors Digest is ready to introduce his breakthrough inventions to the world and better ...
(Date:2/8/2016)... York, NY (PRWEB) , ... February 08, 2016 , ... ... are too much to handle, you are not alone. According to the Center for ... include heart disease, stroke, type 2 diabetes and certain types of cancer, some of ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Steve Helwig ... with a vital new community enrichment program, has teamed up with Citizens Opposed to ... children suffering from intimate abuse. To support all those victimized by the fear of ...
(Date:2/8/2016)... ... February 08, 2016 , ... Local insurance agency Dennis ... FL area, has initiated a fundraiser for a two year old little girl ... after Christmas. To support this beautiful child who is facing life’s journey without ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... new report "Global Diagnostic Ultrasound Devices Market Assessment & Forecast: 2015-2019" ... diagnostic ultrasound devices market was valued at US$ 5,381.1 million in ... at a CAGR of 6.8% from 2015 to 2019. The ... for six geographies of North America , ... Latin America , Middle-East and ...
(Date:2/9/2016)... The global prefilled syringes market accounted for $3,905.1 million ... with a CAGR of 12.9% during 2015-2020. Among the ... global prefilled syringes market, with 90.1% share in 2014. ... global market of prefilled syringes is up surging with ... demand for vaccines, increasing prevalence of chronic and lifestyle ...
(Date:2/9/2016)... report "Global Blood Monitoring & Cardiac Monitoring Devices Market Assessment & ... that global market for blood monitoring & cardiac monitoring devices was ... to US$ 24,830.1 million by 2019 at a CAGR of 6.8% ... Europe , Asia-Pacific , ... Africa . The three major factors determining growth ...
Breaking Medicine Technology: