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DNA from common stomach bacteria minimizes effects of colitis, U-M study says
Date:5/5/2011

ant concerns about global vaccination against H. pylori.

"This bug could be good for you, and we need to understand better what it does," says Owyang.

The H. pylori infection is more commonly found in developing countries or those with poor sanitation, where colitis, Salmonella and inflammatory bowel diseases are less common. Most people contract H. pylori in their first seven years of life, most commonly through an oral-fecal route.

In the study, researchers found that H. pylori DNA is uniquely immunosuppressive containing high numbers of sequences known to inhibit inflammation. They isolated the DNA from both H. pylori and another bacterium, E. coli, for further comparison. They found that mice receiving H. pylori DNA displayed less weight loss, less bleeding and greater stool consistency compared with mice infected with E coli DNA.

"With one dose, there was a significant difference in the bleeding and inflammation in the colon," says Luther. "However, further study is needed to define other potential protective measures that H. pylori may provide and its safety as a treatment in patients."

In previous research, U-M gastroenterologists also found that H. pylori reduced the severity of inflammation of the colon caused by Salmonella in mice.

"It is amazing that the bacterial DNA not only directs the biological behavior of the bacteria, but also has a significant influence on gut immunity of the host. This information might have important implications down the line in our understanding of disease manifestation," says Owyang.


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Contact: Mary F. Masson
mfmasson@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

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