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DNA damage response confers a barrier for viral tumorigenesis
Date:9/27/2007

onstrate that DNA damage checkpoint is activated in early, but not late stage lesions of clinical KS specimens. During the course of infection, the KSHV infected cells may be imposed to overcome this checkpoint, and oncogenic stress elicited by the expression of the viral cyclin may further contribute to the induction of genomic instability and malignant transformation.


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Contact: Pivi Ojala
paivi.ojala@helsinki.fi
358-919-125-548
University of Helsinki
Source:Eurekalert

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