Navigation Links
DNA damage response confers a barrier for viral tumorigenesis
Date:9/27/2007

Kaposis sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposis sarcoma (KS). KSHV infection is endemic in sub-Saharan Africa where KS is nowadays the most common malignancy, due to widespread infection with KSHV and human immunodeficiency virus (HIV). Importantly, KS also occurs in HIV-negative individuals. Researchers at the University of Helsinki, Finland, have discovered that activation of the DNA damage response in the early stages of KS development functions as an anti-cancer barrier also in virus induced malignancies.

Recent findings suggest that DNA damage checkpoints become activated in early stages of human tumorigenesis, leading to growth arrest or apoptosis and thereby hindering tumor progression. DNA hyper-replication triggered by oncogenes can induce cellular senescence, which together with the oncogene-induced DNA damage checkpoint function as an early anti-cancer barrier. The findings by the research group of Pivi Ojala, Ph.D., (University of Helsinki) demonstrate that the DNA damage checkpoint is activated during the initial stages of KSHV infection and KS tumorigenesis and this can confer a barrier to tumorigenesis also in virus induced cancers.

The study will be published 28.9.2007 in Public Library of Science (PLoS) Pathogens.

KSHV displays two patterns of infection: latent and lytic phase. During latency, only a restricted set of viral genes is expressed. The KSHV genome encodes several homologues of cellular proteins, which engage cellular signaling pathways, govern cell proliferation and modulate apoptosis. The results of this study demonstrate that one of the viral latent proteins, viral cyclin, which is a homolog of cellular D-type cyclins, induces replicative stress in endothelial cells, which leads to senescence and activation of the DNA damage response.

To support the finding early stage lesions of clinical KS specimens were analysed in the study. The results demonstrate that DNA damage checkpoint is activated in early, but not late stage lesions of clinical KS specimens. During the course of infection, the KSHV infected cells may be imposed to overcome this checkpoint, and oncogenic stress elicited by the expression of the viral cyclin may further contribute to the induction of genomic instability and malignant transformation.


'/>"/>

Contact: Pivi Ojala
paivi.ojala@helsinki.fi
358-919-125-548
University of Helsinki
Source:Eurekalert

Related medicine news :

1. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
2. New drug to treat Heart Attack and damaged tissue
3. Eating disorder in Diabetic girls lead to eyesight damage.
4. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
5. The flip side of AIDS cocktails – HAART regime damages live
6. Antibiotic induces liver damage in children with E.COLI infections.
7. Women more susceptible to brain damage from ecstasy
8. Body can reshape heart damage
9. New swift therapy limits stroke damage
10. Arthritis Drug May Cause Liver Damage
11. Avacado protects from liver damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... February 13, 2016 , ... Good news ... first in the area to offer AngioPlex™ Optical Coherence Tomography (OCT) Angiography, imaging ... as macular degeneration, diabetic retinopathy, and other vascular conditions. , In just a ...
(Date:2/13/2016)... ... February 13, 2016 , ... Many individuals looking to lead a ... multitude of reasons. IsoPasta by Isolator Fitness has delved into this niche allowing ... without the high-carb repercussions. IsoPasta has 30 grams of protein and only 7 ...
(Date:2/13/2016)... ... February 13, 2016 , ... Christie Medical ... in-kind gift of a VeinViewer® Vision vein finder for the nursing ... start an IV and draw blood, combining technology with traditional technique. , “VeinViewer ...
(Date:2/12/2016)... ... 2016 , ... According to an article published February 4th on ... portion of hernia repairs throughout the United States. Commenting on this article, Beverly Hills ... this trend has not only been expected, but it seems to be a natural ...
(Date:2/12/2016)... Raton, FL (PRWEB) , ... February 12, 2016 ... ... largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving the ... services – hosted over 250 members of South Florida’s philanthropic community at its ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 2016  OMS Supply, a large provider of oral ... today the recent launching of their new company website. ... features that enhance the user experience and enable practitioners ... --> --> Despite the ... that started in early 2016, they have already made ...
(Date:2/11/2016)... -- - Cardiac Marker Diagnostic Testing ... Cancer Therapy. - European Point of Care Diagnostic ... - Key Diagnostic Testing Markets. - Molecular Diagnostics ... Testing. - Molecular Diagnostics in Infectious Disease Testing. ... Products World Markets. - Point of Care Diagnostic ...
(Date:2/11/2016)... 11, 2016  Kindred Biosciences, Inc. (NASDAQ: KIN ... the lives of pets, today announced the submission to ... Animal Drug Application (NADA) for Zimeta™ (dipyrone injection, KIND-012).  ... of Zimeta for the control of pyrexia (fever) in ... --> --> The Chemistry, Manufacturing, ...
Breaking Medicine Technology: