Navigation Links
DNA-coated nanotubes help kill tumors without harm to surrounding tissue
Date:8/19/2009

WINSTON-SALEM, N.C. Researchers at Wake Forest University School of Medicine have destroyed prostate cancer tumors in mice by injecting them with specially-coated, miniscule carbon tubes and then superheating the tubes with a brief zap of a laser.

The procedure, which used DNA-encased, multi-walled carbon nanotubes (MWCNTs) to treat human prostate cancer tumors in mice, left only a small burn on the skin that healed within days.

"That we could eradicate the tumor mass and not harm the tissue is truly amazing," said principal investigator William H. Gmeiner, Ph.D., a professor of cancer biology at the School of Medicine.

An advance copy of the study is now available in the online edition of ACS Nano and the full paper is scheduled to appear in a future print issue.

The researchers envision using the particles not only to kill tumors through heating, but also to target cancer drugs to the diseased area in patients.

"The long-term goal in the project is to be able to use the DNA-encased MWCNTs in multi-modality fashion for a variety of types of tumors," Gmeiner said.

Carbon nanotubes are sub-microscopic particles that have been the subject of intense cancer research. The MWCNTs used in the current study consist of several nanotubes that "fit inside one another like Russian dolls," Gmeiner said. The MWCNTs are injected into a tumor and then heated with laser-generated near-infrared radiation. For this study, the tubes were injected into human prostate cancer tumors being grown in mice. The radiation causes the tubes to vibrate, creating heat. That heat kills the cancer cells near the nanotubes. If there are enough nanotubes, the amount of heat generated can kill whole tumors.

For this study, researchers used MWCNTs encased with DNA, which prevented them from bunching up in the tumor, allowing them to heat more efficiently at a lower level of radiation and leaving the surrounding tissue virtually unharmed.

With funding from the National Cancer Institute and the North Carolina Biotechnology Center, researchers grew 24 prostate cancer tumors in 12 mice. They then separated the mice into groups receiving treatment with DNA-encased MWCNTs and laser, laser only, non-DNA-encased MWCNTs only, or no treatment.

The eight tumors treated with a single injection of DNA-encased MWCNTs and zapped with a 70-second burst from a three-watt laser were gone within six days after treatment. While a minor surface burn appeared at the site of laser treatment, it healed within a few days with antibiotic ointment, Gmeiner said.

The tumors in the other treatment groups showed no distinguishable reduction.

Using the DNA-encased MWCNTs increased heat production two- to threefold allowing researchers to use fewer nanotubes and a less powerful laser to kill tumors an important consideration as scientists determine potential issues with the toxicity of nanotubes, since they remain in the body after treatment, Gmeiner said.

Current thermal ablation, or heat therapy, treatments for human tumors include radiofrequency ablation, which causes regional heating between two electrodes implanted in tissue but cannot be used to selectively distinguish cancer cells from healthy cells, like researchers hope they will be able to do with MWCNTs. In addition to the DNA-encased MWCNTs used in this study, other nanomaterials, such as single-walled carbon nanotubes and gold nanoshells, are also currently undergoing experimental investigation as cancer therapies.

Before treatment with MWCNTs can be tested in humans, studies need to be done to test the toxicity and safety, looking to see if the treatment causes any changes to organs over time, as well as the pharmacology of the treatment, to see what happens to the nanotubes, which are synthetic materials, over time.


'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Scientists get first look at nanotubes inside living animals
2. Radio waves fire up nanotubes embedded in tumors, destroying liver cancer
3. Carbon Nanotubes That Look Like Asbestos, Behave Like Asbestos
4. Carbon nanotubes that look like asbestos, behave like asbestos
5. Researchers effectively treat tumors with use of nanotubes
6. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
7. Study suggests brain tumors need treatment with multiple targeted drugs
8. Bright tumors, dim prospects
9. Genomic profiling of lung tumors helps doctors choose most effective treatment
10. Gene Tests Match Up Lung Tumors, Best Treatment
11. Endoscopic resection is a safe and effective treatment for gastrointestinal smooth muscle tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... 2017 , ... Veteran Theresa James awoke to the sound of her newly ... “Healing Tears,” James depicts every parent’s worst nightmare, when her three children were violently ... and situations throughout my divorce,” James said. “After the death of my children, I ...
(Date:4/24/2017)... ... ... My T Chai, a South African company that creates a number of ... a popular website specializing in sales of nutritional products. , Chai tea is ... It spread across Asia and Africa quickly, and today recipes vary from region to ...
(Date:4/24/2017)... ... April 24, 2017 , ... In 2017, up to ... approximately 25,000 of them will be malignant.(1) As research into precision medicine continues, ... healthcare model in the diagnosis and treatment of brain tumors. Healthcare facilities that ...
(Date:4/24/2017)... ... 2017 , ... As a former supermodel known for her timeless beauty, Joan ... single women is that she put all the words in her new book, "Manifest ... personal experiences and sparkling sense of humor have inspired her to write a book ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... shows that over the last decade, student well-being has seriously declined. "When disenfranchised ... of formal education, join the Islamic State to turn the historic multi-ethnic and ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , Tenn. and DALLAS , April ... EndoStim, Inc., announced that the first patients in ... the EndoStim device in the Lower Esophageal Sphincter Stimulation ... a minimally-invasive implantable device designed to provide long-term reflux ... neurostimulation. GERD affects nearly 65 million people ...
(Date:4/19/2017)... , April 19, 2017 ... stimulate an immune response in pets such as ... products are of various types such as Attenuated ... Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated ... as virus or bacteria, which have been weakend ...
(Date:4/19/2017)... 2017  SARES•REGIS Group leased the first of ... Conejo Spectrum Business Park in Thousand ... Inc. , a biopharmaceutical company developing meaningful therapies ... have been underserved by scientific innovation, with an ... autoimmune and infectious disease. Before commencement ...
Breaking Medicine Technology: