Navigation Links
DNA-altering enzyme is essential for blood cell development
Date:6/10/2013

The expression of specific genes is partially dictated by the way the DNA is packed into chromatin, a tightly packed combination of DNA and proteins known as histones. HDAC3 is a chromatin-modifying enzyme that regulates gene expression, chromatin structure, and genome instability and it has previously been shown to associate with the oncoproteins that drive leukemia and lymphoma. In this issue of the Journal of Clinical Investigation, Scott Hiebert and colleagues at Vanderbilt University examined the role of HDAC3 in the development of blood cells (hematopoiesis) by disrupting its expression in mice. Loss of Hdac3 nearly eliminated all blood immune cells and caused mild anemia. Hiebert and colleagues observed that, in the absence of Hdac3, stem and progenitor cells, which give rise to blood cells, failed to grow normally. These studies identify a role for HDAC3 in stem cell functions and possibly bone marrow failure syndromes, in which the bone marrow fails to produce blood cells.


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Protease Leads Feed Enzyme Market as Compared to Phytase & NSP Says New Research Report at ReportsnReports.com
2. Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
3. Groundbreaking UK study shows key enzyme missing from aggressive form of breast cancer
4. xR: The Human Genome Project has Delivered on its Promise to Treat Disease. Introducing GEMS, the Genetic Enzyme Methylation Syndrome
5. University of Minnesota researchers discover enzyme behind breast cancer mutations
6. Super enzyme protects against dangers of oxygen
7. Mayo Clinic researchers identify enzyme involved in deadly brain tumors
8. Penn team developing new class of malaria drugs using essential calcium enzyme
9. Enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia
10. Fast-acting enzymes with 2 fingers: Protein structurally and dynamically explained
11. Mayo Clinic researchers identify enzyme linked to prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... structure could help predict how willing you are to take ... University found those with greater volume in a part of ... likely to engage in risky behavior than people with less ... the U.S. National Institute on Aging, involved two groups of ... researchers sought to determine how brain structure influences risk taking ...
(Date:9/19/2014)... FRIDAY, Sept. 19, 2014 (HealthDay News) -- Although ... key health benefits, most middle-aged and older adults ... type of exercise, according to new research. ... the muscle-strengthening recommendations set by the Department of ... Strength is essential for promoting health and ...
(Date:9/19/2014)... By Alan Mozes ... (HealthDay News) -- Cancer patients burdened by stress and ... for complications following their operation, a new study suggests. ... "deficit" appeared to have a nearly three times greater ... or good quality of life. "We,ve long known ...
(Date:9/19/2014)... York, NY (PRWEB) September 19, 2014 ... statin medication caused some patients to develop Type 2 ... litigation now underway in U.S. District Court, District of ... Status Report issued on September 12, 2014, discovery is ... things, the report noted that Pfizer, Inc., the manufacturer ...
(Date:9/19/2014)... using intact cells to treat and cure disease ... it is hindered by the inability of doctors and ... of these cells in patients without resorting to invasive ... September 17 in the online journal Magnetic Resonance ... San Diego School of Medicine, University of Pittsburgh and ...
Breaking Medicine News(10 mins):Health News:Brain Structure Might Help Predict Risky Behavior 2Health News:Adults Over 45 Not Meeting U.S. Muscle Strengthening Guidelines, Study Says 2Health News:Family Squabbles Can Derail Recovery From Cancer Surgery 2Health News:Family Squabbles Can Derail Recovery From Cancer Surgery 3Health News:Lipitor Lawsuits Move Forward, as Discovery Proceeds in Federal Multidistrict Litigation, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuits Move Forward, as Discovery Proceeds in Federal Multidistrict Litigation, Bernstein Liebhard LLP Reports 3Health News:A better way to track emerging cell therapies using MRIs 2
... By Jenifer Goodwin HealthDay Reporter , THURSDAY, ... antigen (PSA) levels are rising rapidly over time are of ... be done, a new study indicates. PSA is a ... of PSA can be a marker for prostate cancer, although ...
... By Amanda Gardner HealthDay Reporter , THURSDAY, Feb. ... plague will probably remain a scourge of centuries past, isolated ... fact, according to a just-released government report, a American lab ... of plague from a laboratory-acquired infection since 1959 and the ...
... , THURSDAY, Feb. 24 (HealthDay News) -- ... risk of cancer due to high radiation doses, and ... radiation exposure, a new study suggests. The researchers ... dialysis also have other health conditions that require them ...
... cancer organizations have recommended that men with a rapid rise ... there is no other indication and the PSA is within ... PSA velocityis a poor predictor of prostate cancer, and may ... online February 24 in the Journal of the National ...
... link between victimization experiences and substance abuse has been ... Chicago. The correlation is especially prevalent among gays, ... says Tonda Hughes, professor and interim head of health ... is lead author of the study, published in the ...
... THURSDAY, Feb. 24 (HealthDay News) -- A mouse heart rapidly ... a day after birth, scientists report. With this discovery, ... be found to help the human heart heal itself. ... but they,re somehow permanently switched off," said Eric Olson, co-senior ...
Cached Medicine News:Health News:Rapid Rise in PSA Levels a Poor Predictor of Prostate Cancer: Study 2Health News:Rapid Rise in PSA Levels a Poor Predictor of Prostate Cancer: Study 3Health News:Plague Kills U.S. Lab Worker 2Health News:Plague Kills U.S. Lab Worker 3Health News:Many Dialysis Patients at Risk for High Radiation Exposure 2Health News:PSA velocity screening for prostate cancer may lead to unnecessary biopsies 2Health News:Strong link found between victimization, substance abuse 2Health News:Scientists Say Newborn Mice Can Regrow Damaged Hearts 2
(Date:9/19/2014)... BETHESDA, Md. , Sept. 19, 2014 ... an initiative to harmonize global post-approval changes protocols. ... level of interest in the topic expressed by industry participants ... workshop, held earlier this month in Washington, ... and EMA were on hand for the workshop. Attendees ...
(Date:9/19/2014)... Sept. 19, 2014 Kiromic, LLC, a ... Kent Hance , the former chancellor of Texas Tech ... as chancellor in July 2014, after raising $1.2 billion for ... Kent Hance , the most successful chancellor in the ... not only as an investor, but also as our new ...
(Date:9/19/2014)... Research and Markets has announced the addition of ... Mental Disorder) Market - Forecast to 2023" report to ... the human microbiome market is segmented by application, disease, product, ... to be valued as $294 million in 2019 and is ... forecast period of 2019-2023. The market is driven by growing ...
Breaking Medicine Technology:PDA Launches Effort to Harmonize Global Post-Approval Changes Protocols 2Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 3
... ALISO VIEJO, Calif., Nov. 9 Clarient, Inc. (Nasdaq: ... oncologists and the pharmaceutical industry, today announced that it is ... New York City. , The first presentation will be made ... 1:40 pm EST on Tuesday, November 17. The conference will ...
... Care Reform Bill , Critical legislation would strengthen ... Nov. 7 Today the United States House ... strengthen Medicare for seniors and end discrimination by insurance companies ... , The Affordable Health Care for America Act ...
Cached Medicine Technology:Clarient to Present at Upcoming Healthcare Investor Conferences in New York City 2AARP Idaho Key Vote News Alert 2AARP Idaho Key Vote News Alert 3
Bio-Rad's ScanGel® cards for ABO reverse grouping, antibody screening and crossmatching include - ScanGel Neutral, ScanGel Coombs, Anti-IgG, -C3d (AHG), ScanGel Coombs + Neutral, ScanGel Anti-Ig...
... The Criterion Dodeca cell, a component of the ... up to 12 Criterion gels in a single ... x 8.7 cm) than the traditional mini gel. ... to give you the optimal combination of separation ...
... The PROTEAN Plus Dodeca cell accommodates ... the capacity of first-dimension runs in the ... in a convenient format. The PROTEAN Plus ... with its plate electrodes, allow consistent, high-resolution ...
... ElectroXpress gel electrophoresis system mirrors a 96-well ... screening of PCR products to take place ... source (96-well) plate. Loading can be carried out ... first time in the industry two sets ...
Medicine Products: