Navigation Links
DNA Test Misses Virus That Causes Hearing Loss

Saliva test still better for detecting CMV in newborns, study finds

TUESDAY, April 13 (HealthDay News) -- New research shows that testing DNA in blood samples routinely collected from newborns is not an effective way to detect cytomegalovirus (CMV), an infection that's a major cause of hearing loss in children.

Dried blood spots (DBS) are collected from all infants born in the United States to conduct metabolic screening. Since these blood samples are readily available, there is great interest in using a DNA test called polymerase chain reaction (PCR) to test for CMV.

In this study, U.S. researchers compared CMV detection using DBS real-time PCR testing and saliva rapid culture testing, which can be used for identifying CMV but isn't suitable for mass screening. Compared with saliva rapid culture testing, DBS real-time PCR had low sensitivity and did not identify approximately two-thirds of the CMV infections.

"These results have major public health implications because they indicate that such methods, as currently performed, will not be suitable for the mass screening of newborns for congenital CMV infection, the most common non-genetic cause of deafness in the United States," wrote Dr. Suresh B. Boppana, of the University of Alabama at Birmingham, and colleagues.

"As the disease burden from congenital CMV infection remains a significant public health problem, there continues to be a need to identify the large number of infants with clinically inapparent congenital CMV infection early in life," Boppana said. "The results of our study underscore the need for further evaluation of high-throughput methods performed on saliva or other specimens that can be adapted to large-scale newborn CMV screening."

The study appears in the April 14 issue of the Journal of the American Medical Association.

Of the 20,000 to 40,000 U.S. infants born each year with CMV infection, 90 percent to 95 percent have no obvious signs at birth and aren't identified by routine clinical examination, the researchers said. The ability to identify children at increased risk for CMV-associated hearing loss early in life would enable doctors to intervene at critical stages of speech and language development.

More information

The American Academy of Family Physicians has more about cytomegalovirus.

-- Robert Preidt

SOURCE: Journal of the American Medical Association, news release, April 13, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Presidents As Popular as a Root Canal Comment Misses Mark
2. UBC graduate student finds a start/stop switch for retroviruses
3. Good Bye, Snake Oil! Grab your Orange Juice and Daily Virus Viper™ to Safeguard Against Micro-nutrient Deficiencies
4. Demystifying a Common, Persistent Virus
5. H1N1 Virus Yields Up More Secrets
6. FDA Asks Docs to Suspend Using Glaxo Rotavirus Vaccine
7. GlaxoSmithKline Statement on New Information Relating to Manufacture of Rotarix (Rotavirus Vaccine)
8. Reovirus may be a novel approach to prostate cancer treatment
9. Infectious Virus Hides In Human Chromosomes During Latency And Can Be Passed From Parents To Their Children
10. Researchers find further evidence linking Epstein-Barr virus and risk of multiple sclerosis
11. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
Post Your Comments:
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... ... ... Comfort Keepers® of San Diego, CA is excited to announce they are ... drive cancer patients to and from their cancer treatments. Comfort Keepers provides quality ... and ongoing independence. Getting to and from medical treatments is one of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their ... Award, an essay contest in which patients and their families pay tribute to a ... the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital ... area economy by obtaining investment capital for emerging technology companies. SCP has ... have already resulted in more than a million dollars of capital investment for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
Breaking Medicine Technology: