Navigation Links
DNA Test Misses Virus That Causes Hearing Loss
Date:4/13/2010

Saliva test still better for detecting CMV in newborns, study finds

TUESDAY, April 13 (HealthDay News) -- New research shows that testing DNA in blood samples routinely collected from newborns is not an effective way to detect cytomegalovirus (CMV), an infection that's a major cause of hearing loss in children.

Dried blood spots (DBS) are collected from all infants born in the United States to conduct metabolic screening. Since these blood samples are readily available, there is great interest in using a DNA test called polymerase chain reaction (PCR) to test for CMV.

In this study, U.S. researchers compared CMV detection using DBS real-time PCR testing and saliva rapid culture testing, which can be used for identifying CMV but isn't suitable for mass screening. Compared with saliva rapid culture testing, DBS real-time PCR had low sensitivity and did not identify approximately two-thirds of the CMV infections.

"These results have major public health implications because they indicate that such methods, as currently performed, will not be suitable for the mass screening of newborns for congenital CMV infection, the most common non-genetic cause of deafness in the United States," wrote Dr. Suresh B. Boppana, of the University of Alabama at Birmingham, and colleagues.

"As the disease burden from congenital CMV infection remains a significant public health problem, there continues to be a need to identify the large number of infants with clinically inapparent congenital CMV infection early in life," Boppana said. "The results of our study underscore the need for further evaluation of high-throughput methods performed on saliva or other specimens that can be adapted to large-scale newborn CMV screening."

The study appears in the April 14 issue of the Journal of the American Medical Association.

Of the 20,000 to 40,000 U.S. infants born each year with CMV infection, 90 percent to 95 percent have no obvious signs at birth and aren't identified by routine clinical examination, the researchers said. The ability to identify children at increased risk for CMV-associated hearing loss early in life would enable doctors to intervene at critical stages of speech and language development.

More information

The American Academy of Family Physicians has more about cytomegalovirus.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, April 13, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Presidents As Popular as a Root Canal Comment Misses Mark
2. UBC graduate student finds a start/stop switch for retroviruses
3. Good Bye, Snake Oil! Grab your Orange Juice and Daily Virus Viper™ to Safeguard Against Micro-nutrient Deficiencies
4. Demystifying a Common, Persistent Virus
5. H1N1 Virus Yields Up More Secrets
6. FDA Asks Docs to Suspend Using Glaxo Rotavirus Vaccine
7. GlaxoSmithKline Statement on New Information Relating to Manufacture of Rotarix (Rotavirus Vaccine)
8. Reovirus may be a novel approach to prostate cancer treatment
9. Infectious Virus Hides In Human Chromosomes During Latency And Can Be Passed From Parents To Their Children
10. Researchers find further evidence linking Epstein-Barr virus and risk of multiple sclerosis
11. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... FL (PRWEB) , ... April 24, 2017 , ... ... Paul Gallardo, DDS, PA will be attending the 2017 Oral Reconstruction Foundation’s 2017 ... 2017. , The Oral Reconstruction Foundation will present its annual Global Symposium at ...
(Date:4/24/2017)... WA (PRWEB) , ... April 24, 2017 , ... ... leading lifestyle brands, work wear distributors and International relief organizations across the globe ... The company also offers lifestyle and work wear collections via insectshield.com . ...
(Date:4/24/2017)... ... April 24, 2017 , ... A 2-in-1 bottleless water ... place. From 101 Water Texas, here are the ways in which this technology ... continuous supply of pure, fresh, oxygenated water, with both cold and hot options. ...
(Date:4/23/2017)... ... 2017 , ... Altura Communication Solutions, a nationwide provider of ... and SMB specialization. Altura is now qualified to sell, install and support ... Certification, Altura fulfilled the training and exam requirements for the Cisco Small Medium ...
(Date:4/22/2017)... Philadelphia, PA (PRWEB) , ... ... ... Small Business Administration of Eastern Pennsylvania has named PROSHRED® Security of ... Pennsylvania-native Ginny Heron-Doerr, PROSHRED® Philadelphia specializes in providing information destruction ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... AMSTERDAM , April 20, 2017  AbbVie ... that 99 percent (n=145/146) of chronic hepatitis C ... 4, 5 or 6 and compensated cirrhosis (Child-Pugh ... post-treatment (SVR 12 ) with its investigational, pan-genotypic ... rates were seen following 12 weeks of ...
(Date:4/20/2017)... , April 20, 2017 NeuroVive ... ("NeuroVive") today announced positive preclinical results demonstrating ... compound for non-alcoholic steatohepatitis (NASH), in an ... NV556 has previously shown similar ... model. Today, NeuroVive,s scientists present novel data ...
(Date:4/19/2017)... NEW YORK , April 19, 2017 Cardiology ... during the projected period The Cardiology Devices segment ... more than US$ 15 Mn in 2018 over 2017. By ... reach a market valuation close to US$ 700 Mn, expanding ... Cardiology Devices segment dominated the Asia Pacific ...
Breaking Medicine Technology: