Navigation Links
DNA May Explain Why Women Have More Rheumatoid Arthritis
Date:11/26/2012

MONDAY, Nov. 26 (HealthDay News) -- Genes specific to the X chromosome are among newly identified genes linked to rheumatoid arthritis and could help explain why women are more likely than men to develop the disease, researchers say.

Women have two X chromosomes while men have an X and a Y chromosome.

The X-chromosome-specific genes were among 14 newly identified genes in both women and men that can lead to rheumatoid arthritis, adding to the 32 genes previously pinpointed by the researchers at the Arthritis Research U.K. Epidemiology Unit at the University of Manchester and their colleagues.

It is believed that these 46 genes account for the vast majority of genes associated with rheumatoid arthritis. The research could lead to new treatments for the disease, according to the study published online recently in the journal Nature Genetics.

"This groundbreaking study brought together scientists from around the world and involved the use of DNA samples from more than 27,000 patients with rheumatoid arthritis and healthy controls," study lead author Jane Worthington, professor of chronic disease genetics at the University of Manchester, said in a university news release. "As a result of our findings, we now know that genetic variations at over 45 regions of the genome determine susceptibility to this form of arthritis."

Rheumatoid arthritis is different from osteoarthritis, the arthritis associated with aging and wear and tear. It frequently starts between the ages of 25 and 55, and causes inflammation in the joints, resulting in swelling, stiffness, pain and reduced joint function.

Lifestyle and environmental factors such as smoking, diet, pregnancy and infection are believed to play a role in rheumatoid arthritis, but a person's genes also influence their risk for the disease. The condition affects about 1 percent of the world's population.

"This work will have a great impact on the clinical treatment of arthritis; we have already found three genes that are targets for drugs, leaving a further 43 genes with the potential for drug development, helping the one-third of patients who fail to respond well to current medications," study first author Dr. Stephen Eyre said in the news release.

"This is the first time that a genetic association has been established between rheumatoid arthritis and the X chromosome," Alan Silman, medical director of Arthritis Research U.K., said in the release. "This could provide a useful clue in helping us to understand why rheumatoid arthritis is three times more likely to occur in women."

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about rheumatoid arthritis.

-- Robert Preidt

SOURCE: University of Manchester, news release, November 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Queens research gives fresh hope to couples with unexplained infertility
2. Rise in Pregnancy-Associated Cancers Not Fully Explained by Older Age
3. Immune system protein could explain pancreatitis
4. Why are elderly duped? UI researchers explain why
5. Scientists discover new clues explaining tendon injury
6. Discovery explains how cellular pathways converge to regulate food intake and body weight
7. US Drug Watchdog Now Offers to Help All Woman Who Used Fosamax For Osteoporosis and Then Had an Unexplained a Femur Break Get to the Best Attorneys
8. Shorter Arms May Explain Why Women Need Glasses Sooner Than Men
9. New mouse model helps explain gene discovery in congenital heart disease
10. US Drug Watchdog Now Offers To Help Women Who Used TheOsteoporosis Drug Called Fosamax And Then Had A Unexplainable Femur Fracture Get To The Best Attorneys Or Law Firms
11. Wake Forest Baptist research provides clue to unexplained excited delirium deaths
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA May Explain Why Women Have More Rheumatoid Arthritis
(Date:8/16/2017)... ... 16, 2017 , ... Paul Vitenas, MD, FACS , is honored to ... annual list identifies the nation’s top physicians, in a variety of specialties. This marks ... top of Castle Connolly’s coveted ranking. , Castle Connolly is the nation’s trusted provider ...
(Date:8/16/2017)... ... August 16, 2017 , ... SGNA Standards of Infection Control ... cycle, both between patient procedures and before storage, is a requisite practice crucial ... to the prevention of disease transmission and nosocomial infection as cleaning and HLD.” ...
(Date:8/16/2017)... ... August 16, 2017 , ... Richard Strawn’s new ... during the time of a cancer diagnosis, surgery and recovery, the Psalms provided ... the many ways God shows love to those who are sick., Surgical Psalms ...
(Date:8/16/2017)... , ... August 16, 2017 , ... ... offering an opportunity for men and women to train as hospice volunteers. Volunteers ... with life-limiting illness. For over 30 years, the agency has trained volunteers to ...
(Date:8/16/2017)... ... August 16, 2017 , ... Rollon Skin Care ... skincare solutions, recently announced the launch of two new skincare products, Prache Antiaging ... alternative to expensive plastic surgery or in-patient cosmetic dermatological procedures. , “Prache Antiaging ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... , Aug. 2, 2017 Fenita ... Who as a Pinnacle Lifetime Professional in the ... Account Manager at Turing Pharmaceuticals, AG. Her skills ... and relationship building.                ... than 25 years of experience as a highly ...
(Date:8/2/2017)... 2017 CaryRx, a next-generation full-service pharmacy, has announced ... patients in the Washington D.C. metropolitan ... providing delivery of medications through the convenience of its patient-friendly ... delivered within one hour to any location in D.C. ... this invaluable service to Washington D.C. ," says ...
(Date:7/31/2017)... July 31, 2017 Three Tru-D SmartUVC robots have ... South Korea . Tru-D, short for "Total Room Ultraviolet Disinfection," is ... after an environmental services (ES) professional cleans the area with traditional cleaning ... Tru-D fights ... "Although the BAACH has a ...
Breaking Medicine Technology: