Navigation Links
DNA Fingerprints Predict Brain Disorders
Date:1/18/2008

Researchers found certain variations may indicate higher risk of ALS, Parkinson's

FRIDAY, Jan. 18 (HealthDay News) -- Predicting brain disorders such as Parkinson's disease and amyotrophic lateral sclerosis (ALS) may be possible by identifying certain DNA fingerprints, a recent Mayo Clinic study suggests.

The researchers analyzed the genetic data of people with ALS (also known as Lou Gehrig's disease) and Parkinson's, and those without neurological disorders. They pinpointed several gene variations that predicted who was at higher risk for developing the disorders, according to the study published online in PLoS One.

The variations were found by studying the axon guidance pathway, a complex collection of chemical signals that wire the brain during fetal development, and maintain and repair brain circuits throughout a person's life.

Researchers found many variations within pathway genes common to ALS and Parkinson's. However, they also identified several that collectively indicate people at high risk (2,000 times greater than the general population) for ALS. And they pinpointed several gene variations that collectively predicted people at high risk (nearly 400 times greater than the general population) for Parkinson's disease.

"In persons at high risk, we may be able to prevent the diseases or slow or halt their progression by developing drugs that target the same disease pathways. For ALS and Parkinson's disease, our study is a major step in these directions," principal investigator and Mayo Clinic neurologist Dr. Demetrius Maraganore said in a prepared statement.

ALS is a progressive neurodegenerative disease that leads to loss of muscle control and use, and eventually death. As many as 30,000 Americans have the disease at any given time, according to the ALS Association. Parkinson's disease, a brain disorder that affects 1.5 million Americans, causes tremors, slowness of movement, and body stiffness, according to the National Parkinson Foundation. No cure exists for either disease.

More information

The Muscular Dystrophy Association has more about ALS.



-- Robert Preidt



SOURCE: Mayo Clinic, news release, Jan. 15, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. U.S. Preventive Medicine(R) Predicts Robust Growth Ahead
2. UQ research predicts type 2 diabetes explosion
3. Simple test accurately predicts risk of serious jaundice in newborns
4. 5 Factors Help Predict Psychosis in Children
5. Private Equitys Top Execs to Share Advice, Candid Predictions at 2008 Outlook Conference
6. American Council On Exercise (ACE) 2008 Fitness Trend Predictions
7. Area Around Breast Tumor May Predict Cancers Spread
8. Six Positive Predictions for 2008, from SuperLife World Service
9. Bone Density Tests Do Predict Womens Fracture Risk
10. MammaPrint(R) Breast Cancer Test Shown To Be Powerful Tool for Prognosis Prediction in Postmenopausal Breast Cancer Patients
11. Predicting post-traumatic stress disorders in deployed veterans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA Fingerprints Predict Brain Disorders
(Date:6/25/2017)... ... June 25, 2017 , ... CareSet Labs released the Root NPI Graph today ... a new, greatly improved version of the Doctor Referral teaming dataset commonly available from ... and subsequently called the the “Doctor Referral Dataset” as released by Medicare and “DocGraph” ...
(Date:6/24/2017)... ... June 24, 2017 , ... The Pennsylvania Athletic ... Erie Bayfront and Erie Convention Center on June 8-10. The weekend consisted ... quiz bowl, award and scholarship presentations, and professional networking. , On Friday ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode Island ... Care Management Alerts and Dashboards, an innovative new service enabling healthcare providers to ... Care Management Alerts and Dashboards provide near real-time data about patients admitted to ...
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that carotenoids ... risk of visual loss in these patients. , But how often do ophthalmologists and ... cessation to patients at risk of or with early symptoms of AMD? A ...
(Date:6/23/2017)... ... 2017 , ... Everybody has their own personal preference when it comes to ... some people don't like it at all. FindaTopDoc took a look at what makes ... can give readers a taste of their deepest, darkest fantasies and has the ability ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... INDIANAPOLIS , June 9, 2017 More ... a further effort to help spread lessons learned from ... the International Diabetes Federation (IDF) and Eli Lilly and ... for the second phase of the Bringing Research in ... reaffirming their commitment to helping people with diabetes effectively ...
(Date:6/8/2017)... 2017   Responding to Heath Ledger,s father,s ... of singer Chris Cornell in May, the mental ... a free online psychiatric drug side effects ... about psychotropic drug risks. The father of ... an accidental overdose, has called for tighter rules on prescription ...
(Date:6/7/2017)... , June 7, 2017 Endo International plc ... 7, 2017, the Hon. Joseph R. Goodwin , ... West Virginia , entered a case ... Pelvic Repair System Products Liability Litigation (the "MDL") that ... cases to provide expert disclosures on specific causation within ...
Breaking Medicine Technology: