Navigation Links
DNA Fingerprinting Could ID Viable Embryos
Date:5/14/2008

Finding may lead to improved pregnancy rates for in vitro patients, fewer multiple pregnancies

TUESDAY, May 13 (HealthDay News) -- Researchers say DNA tests may be able to tell doctors which embryos tabbed for in vitro fertilization (IVF) are most likely to result in the births of healthy babies.

The technique, discussed in a report published online May 14 in Human Reproduction, could also help fertility experts prevent accidental multiple pregnancies in their IVF patients.

A woman's eggs are fertilized with sperm during IVF and then allowed to develop in the laboratory for about five days until they reach the blastocyst, or very early embryo, stage. Doctors then decide which blastocysts look most likely to develop successfully and how many to put into the woman's womb.

Since reliable tests for determining which blastocysts are viable do not exist, couples often choose to have more than one blastocyst implanted in the woman's womb. While this increases the chances of a successful pregnancy, it also raises the risk of a woman becoming pregnant with two or more babies at once. Multiple pregnancies bring added dangers to the mother and babies.

In the study, researchers removed cells from the blastocysts being developed for 48 women, 25 of whom later became pregnant from the fertilized eggs resulting in 37 babies being born. The DNA from these cells was matched with the babies' DNA, thereby telling researchers which blastocysts developed into babies.

In analyzing the expression of genes in the viable and non-viable blastocysts, the team noted differing patterns. The genes expressed in the viable blastocysts, for example, are involved in cell adhesion, cell communication, cellular metabolic processes and response to stimuli -- all key processes involved in embryo implantation.

This finding could lead to doctors being able to select the single most viable embryo from a group for transfer from the laboratory to the womb, the researchers said.

"One of the major stumbling blocks to worldwide acceptance of a single embryo transfer policy is the lack of highly predictive criteria to select the single most viable embryo within a cohort," co-author Dr. Gayle Jones, senior research scientist at the Monash Immunology and Stem Cell Laboratories, said in a prepared statement. "The ability to use objective, measurable criteria rather than subjective observations, such as morphology, should improve the predictive value and provide sufficient confidence for clinicians to shift towards single embryo transfers for all patients without a concomitant drop in pregnancy rates. This would effectively reduce multiple pregnancies, which is a priority in the field of assisted reproductive medicine at present."

More work needs to be undertaken before these findings become applicable in the clinic, the researchers said.

More information

The American Society for Reproductive Medicine has more about infertility.



-- Kevin McKeever



SOURCE: European Society for Human Reproduction and Embryology, news release, May 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Medicare Fee Cuts Could Devastate Rehabilitation Services, Physical Therapists Warn Congress
2. Noise in Artery Could Warn of Heart Risk
3. Computer games high score could earn the Nobel Prize in medicine
4. Telemedicine could eradicate many expensive ED visits
5. Common Medications Could Cause Physical Impairment in the Elderly
6. New Lewin Group Analysis: Medicare Cuts for Nursing Facility Care Could Have Economic Impact Up to $4.2 Billion, Threaten Jobs
7. New treatment could reduce chronic lung disease in premature babies
8. Crime Scene Investigation methods could help in the battle against hospital infections
9. Cancer could return unless stored ovarian tissue undergoes adequate testing before re-implantation
10. Millions of Euros could be saved if breast cancer follow-ups were led by specialist nurses
11. Readily available treatment could help prevent heart disease in kidney patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... ... Premier Fitness Camp (PFC) and The Chopra Center for Wellbeing announced today the ... their world headquarters of Omni La Costa Resort & Spa in San Diego. , ... loss, personal development, a healthy lifestyle, or mental and physical healing. The week-long wellness ...
(Date:12/8/2016)... ... 2016 , ... STAT courier is pleased to announce that due to customer ... are expanding their presence in Dallas. One of the most exciting parts for STAT ... to the Dallas and Forth Worth market. STAT takes pride in treating their employees ...
(Date:12/8/2016)... AR (PRWEB) , ... December 08, 2016 , ... ... insurance and financial planning services from offices headquartered in Little Rock, has initiated ... Pantry. , According to the National Foundation to End Senior Hunger, Arkansas ranks ...
(Date:12/8/2016)... MS (PRWEB) , ... December 08, 2016 , ... The ... serve commercial and residential clients in and around the Hancock County area, is announcing ... the Hancock County Food Pantry. , The Hancock County Food Pantry has worked for ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... passage of the most comprehensive mental health systems reform legislation in more than ... the President, and the commitment of our elected officials to improving mental health ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... CITY , Dec. 8, 2016 ... US patents for improving the accuracy, reproducibility and ... images in long and small bone orthopaedic applications. ... approach to creating personalized orthopaedic restorations based on ... personalized orthopaedic restorations, the company harnesses the world,s ...
(Date:12/8/2016)... Dec. 8, 2016  A new study by a ... use of opioid therapy to treat chronic pain is ... of more harmful consequences, including death. Palliative ... Zankhana Mehta , M.D., authored the study which ... opioid therapy. The study was published in the December ...
(Date:12/8/2016)... 2016 Information products and services provider ... Scopus , the world,s largest abstract and citation database of ... for journals from over 5,000 publishers. The new set of metrics ... to and when to adjust a journal,s editorial strategy. ... , , ...
Breaking Medicine Technology: