Navigation Links
DNA Damage From Chemo May Help Spur Leukemia's Return
Date:1/12/2012

THURSDAY, Jan. 12 (HealthDay News) -- The chemotherapy used to treat a form of adult leukemia sets a trap that can result in the return of the disease within years, a new study suggests.

The finding confirms the suspicions of specialists who thought chemotherapy drugs could disrupt DNA through mutations and ultimately allow tumor cells to avoid the effects of the medications.

"Chemotherapy drugs are absolutely necessary to get leukemia patients into remission, but we also pay a price in terms of DNA damage," study co-author Dr. Timothy Ley, a professor of oncology at Washington University School of Medicine in St. Louis, said in a university news release.

These drugs "may contribute to disease progression and relapse in many different cancers, which is why our long-term goal is to find targeted therapies based on the mutations specific to a patient's cancer, rather than use drugs that further damage DNA," Ley added.

The type of leukemia in question is known as acute myeloid leukemia. While chemotherapy treatment can send the cancer into remission, 80 percent of patients die within five years. In the United States, about 13,000 cases of acute myeloid leukemia are diagnosed annually, most often in people age 60 and older.

The researchers came to their conclusions after studying the genomes -- the entire DNA, both healthy and cancerous cells -- from eight patients with acute myeloid leukemia. They watched to see what happened after the patients received chemotherapy.

The investigators found that tumors essentially reappeared, according to the report published in the Jan. 11 advance online edition of Nature.

"It's the same tumor coming back but with a twist," co-author Richard Wilson, director of university's Genome Institute, explained in the news release. It "comes back with new mutations that give the cells new strategies for surviving attack by whatever drugs are thrown at them. This
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Omega-3 fatty acids could prevent and treat nerve damage, research suggests
2. Agent shows ability to suppress brain metastasis and related damage
3. Alzheimers damage occurs early
4. Uncovering how cerebral malaria damages the brain
5. Marathons May Damage Part of Heart: Study
6. Toll-like receptors play role in brain damage in newborns
7. Too Much Acetaminophen Over Time May Damage Liver
8. Improved method of electrical stimulation could help treat damaged nerves
9. The serotonin system in womens brains is damaged more readily by alcohol than that in mens brains
10. Stem Cells Show Promise in Healing Damaged Hearts
11. Stem cell research hopes to repair brain damage of Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA Damage From Chemo May Help Spur Leukemia's Return 
(Date:9/1/2015)... ... ... With former IBMers among its founding members, Inmar has known the value of ... ago. A pilot program begun by the company in 2014 has proved popular with ... pursuing careers in these fields. The program is now open to area middle and ...
(Date:9/1/2015)... ... September 01, 2015 , ... Royal River Natural Foods, a locally-owned independent natural ... women for 19 years and found that, among those who had a stroke, people ... report is part of the September 2015 issue of “Natural Insights for Well Being,” ...
(Date:9/1/2015)... ... 2015 , ... The FSH Society , the Massachusetts-based charity that has ... be the beneficiary of a collection of fundraising events this fall. From Boston to ... FSH Society and further FSHD research. , The list of 2015 fall ...
(Date:9/1/2015)... , ... September 01, 2015 , ... SC&H Group, a ... which includes being named a “Best of the Best” firm in the U.S., as ... named the “Best of the Best” in the U.S., selected exclusively on performance in ...
(Date:9/1/2015)... ... 01, 2015 , ... Suzanne Bakken, PhD, RN, FAAN, FACMI ... of Medicine (IOM) of the National Academies. , She is the Alumni Professor ... A member of the Institute of Medicine since 2006, Bakken also currently co-directs ...
Breaking Medicine News(10 mins):Health News:Inmar Announces Program to Fuel Student Passion for STEM – with an Unconventional Twist 2Health News:New Study Finds Multivitamins Extend Life After Stroke, Retailer Reports 2Health News:FSH Society Beneficiary of Variety of Fall Fundraising Events 2Health News:FSH Society Beneficiary of Variety of Fall Fundraising Events 3Health News:SC&H Group Receives Multiple Honors from INSIDE Public Accounting 2Health News:Columbia Nursing’s Suzanne Bakken Named Distinguished Institute of Medicine Nurse Scholar-in-Residence 2
... and community leaders, who have witnessed first hand the ... the homeless, sick and mentally ill, gathered today at ... sales and use in California. , More than ... and religious denominations, were joined by community activists and ...
... involved in tissue damage caused by smoking , WEDNESDAY, ... gene therapy for injured lungs that were previously rejected ... for transplant, researchers say. , Successful transplants require healthy ... are highly inflamed and only mildly functional, which means ...
... YORK, Oct. 28 If we get a boo-boo, we might ... our mom kiss it and make it all better. But, ... most of us who aren,t prepared for dental emergencies can quickly ... Majestic Drug Company at: , http://inr.mediaseed.tv/oneClip_C/?feed=Ss8P5Rb1iQulYDAELUR0M_kpwKp_6YSM ...
... asks Nelson to oppose any healthcare bill with tax increases ... Reform (ATR) continued its pressure on Sen. Ben Nelson (D-Neb.) ... Senate healthcare bill because it violates the Taxpayer Protection Pledge. ... , urges Sen. Nelson to be a "no" vote on ...
... Webmedx , the fourth largest medical transcription ... sales of medical records in India as further proof that ... to maintain standards of privacy and security. In an era ... protected health information, the onus on transcription service providers is ...
... , RESTON, Va., Oct. 28 Clinical Care Options ... print, and live medical education programs and medical education ... HIV inPractice , a new, free, online point-of-care ... management of HIV/AIDS. , "CCO HIV inPractice will empower ...
Cached Medicine News:Health News:Faith-Based Leaders and Community Activists Converge on State Capitol to Oppose Legalized Marijuana 2Health News:Faith-Based Leaders and Community Activists Converge on State Capitol to Oppose Legalized Marijuana 3Health News:Repairing Injured Lungs May Boost Organ Donations 2Health News:Taxpayer Group Launches Petition to Ask Sen. Ben Nelson to Keep His Pledge 2Health News:Webmedx Reacts to News of Confidential Medical Records Being Sold on the Black Market 2Health News:Clinical Care Options Launches CCO HIV inPractice, a Unique, Free, Comprehensive Online Resource for Healthcare Providers at the Point of Care 2
(Date:9/1/2015)... SPRINGDALE, Ark. , Sept. 1, 2015 NOWDiagnostics Inc., ... completed its acquisition of ZBx Corporation of Canada ... to its vision of a world where people have ... NOWDiagnostics manufactures and sells a line of unique blood-based ... simple-to-use, highly accurate tests for a variety of ailments ...
(Date:9/1/2015)... 1, 2015 UT Southwestern Medical Center President ... members joined U.S. Representatives Michael C. Burgess , ... discussion on the 21 st Century Cures Act, ... considered by the United States ... Academy of Sciences members, department chairs, center directors, and ...
(Date:9/1/2015)... Sept. 1, 2015  Results from an interim analysis ... that 5g of idarucizumab enabled emergency surgery to ... treated with dabigatran (Pradaxa ® dabigatran etexilate ... effect of dabigatran enabled patients to be urgently ... of 1.7 hours between administration of idarucizumab and ...
Breaking Medicine Technology:NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 2U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 4U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 5New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 2New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 3New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 4New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 5New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 6New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 7New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 8New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 9
... in wake of AHA-presented data , ... a clinical trial suggesting rosuvastatin may lower the cardiovascular risk ... statin use in older adults, according to a national poll ... the online poll conducted by medical news site MedPage Today ...
... FRANCISCO, Calif., Nov. 25 Poniard,Pharmaceuticals, Inc. (Nasdaq: ... on,innovative oncology therapies, announced today that it will ... in order to allow,the Company to focus its ... product candidate, and to support the initial commercialization ...
Cached Medicine Technology:Dramatic JUPITER Findings Fail to Sway Prescribing Behavior, Poll Shows 2Dramatic JUPITER Findings Fail to Sway Prescribing Behavior, Poll Shows 3Poniard Pharmaceuticals Announces Management Changes and Focus on Development and Commercialization of Picoplatin 2Poniard Pharmaceuticals Announces Management Changes and Focus on Development and Commercialization of Picoplatin 3
... Right Solution For Your Tracheostomy Care Needs, ... tray features the latest components for efficient ... control task. Designed by clinicians, these latex-free ... each patient and caregiver. All of our ...
... Right Solution For Your Tracheostomy Care Needs, ... tray features the latest components for efficient ... control task. Designed by clinicians, these latex-free ... each patient and caregiver. All of our ...
... alternate care facilities with a wide ... offer the finest in nursing convenience ... guidance of experienced nursing personnel, these ... is required for efficient and quick ...
... alternate care facilities with a wide ... offer the finest in nursing convenience ... guidance of experienced nursing personnel, these ... is required for efficient and quick ...
Medicine Products: