Navigation Links
DNA Damage From Chemo May Help Spur Leukemia's Return
Date:1/12/2012

THURSDAY, Jan. 12 (HealthDay News) -- The chemotherapy used to treat a form of adult leukemia sets a trap that can result in the return of the disease within years, a new study suggests.

The finding confirms the suspicions of specialists who thought chemotherapy drugs could disrupt DNA through mutations and ultimately allow tumor cells to avoid the effects of the medications.

"Chemotherapy drugs are absolutely necessary to get leukemia patients into remission, but we also pay a price in terms of DNA damage," study co-author Dr. Timothy Ley, a professor of oncology at Washington University School of Medicine in St. Louis, said in a university news release.

These drugs "may contribute to disease progression and relapse in many different cancers, which is why our long-term goal is to find targeted therapies based on the mutations specific to a patient's cancer, rather than use drugs that further damage DNA," Ley added.

The type of leukemia in question is known as acute myeloid leukemia. While chemotherapy treatment can send the cancer into remission, 80 percent of patients die within five years. In the United States, about 13,000 cases of acute myeloid leukemia are diagnosed annually, most often in people age 60 and older.

The researchers came to their conclusions after studying the genomes -- the entire DNA, both healthy and cancerous cells -- from eight patients with acute myeloid leukemia. They watched to see what happened after the patients received chemotherapy.

The investigators found that tumors essentially reappeared, according to the report published in the Jan. 11 advance online edition of Nature.

"It's the same tumor coming back but with a twist," co-author Richard Wilson, director of university's Genome Institute, explained in the news release. It "comes back with new mutations that give the cells new strategies for surviving attack by whatever drugs are thrown at them. This makes a lot of sense but it's been hard to prove without whole-genome sequencing."

Commenting on the report, Louis DeGennaro, executive vice president and chief mission officer of the Leukemia & Lymphoma Society, said the study "demonstrates the critical need to identify disease-causing mutations in acute myeloid leukemia so that therapies targeted specifically at these mutations can be developed."

Ultimately, he added, "that would allow us to avoid the use of chemotherapy, which may contribute to cancer relapse."

For now, DeGennaro said, "while current chemotherapy regimens have liabilities, they represent the best treatment currently available and may result in complete remission, which would allow eligible patients to receive a stem cell transplant, the only treatment capable of curing acute myeloid leukemia."

More information

For more about acute myeloid leukemia, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Louis J. DeGennaro, Ph.D., executive vice president and chief mission officer, Leukemia & Lymphoma Society, White Plains, N.Y.; Washington University School of Medicine in St. Louis, news release, Jan. 11, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Omega-3 fatty acids could prevent and treat nerve damage, research suggests
2. Agent shows ability to suppress brain metastasis and related damage
3. Alzheimers damage occurs early
4. Uncovering how cerebral malaria damages the brain
5. Marathons May Damage Part of Heart: Study
6. Toll-like receptors play role in brain damage in newborns
7. Too Much Acetaminophen Over Time May Damage Liver
8. Improved method of electrical stimulation could help treat damaged nerves
9. The serotonin system in womens brains is damaged more readily by alcohol than that in mens brains
10. Stem Cells Show Promise in Healing Damaged Hearts
11. Stem cell research hopes to repair brain damage of Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA Damage From Chemo May Help Spur Leukemia's Return 
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... PUNE, India , June 24, 2016 ... "Pen Needles Market by Type (Standard Pen Needles, Safety ... 12mm), Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase ... published by MarketsandMarkets, This report studies the market for ... is expected to reach USD 2.81 Billion by 2021 ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
Breaking Medicine Technology: