Navigation Links
DNA Coding May Make Bowel Prone to Cancer
Date:6/11/2008

'Addicted' cells provide early diagnosis; diet could affect changes, study says

WEDNESDAY, June 11 (HealthDay News) -- Subtle changes in the DNA's chemical coding may make the bowel more susceptible to cancer by making the cells addicted to turning the switch on in abnormal genes, a new study suggests.

Scientists at the Institute of Food Research, who published their findings in the current issue of the British Journal of Cancer, are now looking at whether one's diet could affect these changes and possible ward off colorectal cancer.

The researchers made their discovery after observing methyl groups attached to DNA taken from the cells lining the large intestine of bowel cancer patients. These groups are part of the "epigenetic code," chemical tags on DNA molecules that determine whether individual genes are turned on or off. Mistakes in the epigenetic code are partially the reason behind the abnormal behavior of cancer cells, which tell certain genes to grow some types of cells while switching off other genes that would cause these abnormal cells to destroy themselves.

"We looked at changes in 18 genes that play a role in the very earliest stages of colorectal cancer," Ian Johnson, of the Institute of Food Research, said in a prepared statement. "We detected clear chemical differences in these genes in otherwise normal tissue in cancer patients. This represents a new way to identify defects that could eventually lead to cancer."

The IFR scientists, with support from two other groups, are now looking into whether epigenetic code mistakes occur in apparently normal tissues long before the appearance of a tumor. They are also investigating whether lifestyle factors such as diet, obesity and exercise can affect DNA methylation as people age. If so, this may give people some control over this part of their long-term health.

"Basic research in the relatively young field of epigenetics is already contributing to our understanding of human health. Understanding how epigenetic processes work to maintain healthy cells and tissues is the key to long-term health, because, as we see here, the breakdown of these normal processes may subsequently cause disease," Nigel Brown, director of science and technology for the Biotechnology and Biological Sciences Research Council, said in a prepared statement. His organization is one of the group's supporting the IFR's study into diet and bowel cancer.

More information

The U.S. National Library of Medicine has more about colorectal cancer .



-- Kevin McKeever



SOURCE: Norwich BioScience Institutes, news release, June 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
2. Enhanced PrecyseCode 2X(TM) Further Accelerates Remote Coding and Improves Cash Flow for Hospitals
3. UT Health Science Center researchers decoding saliva to detect breast cancer
4. By color-coding atoms, new Cornell electron microscope promises big advance in materials analysis
5. Abbott FreeStyle Freedom(R) Lite Blood Glucose Monitoring System Now Available With No Coding for People With Diabetes
6. Decoding Muscle Stem Cell Development
7. The febit science lounge presents: Webinar About Role of Non-Protein-Coding RNA in Human Genome Set for 11 a.m. EDT on June 12
8. Elsevier announces new journal on inflammatory bowel diseases
9. C-diff infection 4 times more likely to kill patients with inflammatory bowel disease
10. Mesalamine linked to cancer protection for high risk inflammatory bowel disease patients
11. Threshold for bowel surgery may be too high, warn experts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
(Date:6/24/2016)... Nevada (PRWEB) , ... June 24, 2016 , ... ... Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations ... in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, ... organization dedicated to helping service members that have been wounded in battle and their ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 ... care operating models within the health care industry is ... financial efficiency , Deloitte offers a suite of ... business issues impacting efficient cost optimization: labor resource analysis, ... These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
Breaking Medicine Technology: