Navigation Links
DNA Analysis Could Help Customize Treatments for MS
Date:1/16/2008

Study suggests it could show who will respond best to interferon beta treatments

WEDNESDAY, Jan. 16 (HealthDay News) -- Genetic differences might explain why some multiple sclerosis (MS) patients respond to treatment while others don't, suggests an international study.

Starting with 206 southern European patients with relapsing-remitting MS, the most common form of the disease, the researchers compared the DNA of patients whose symptoms were reduced by interferon beta therapy to the DNA of those who experienced relapses after such therapy. They were able to identify important genetic differences between the two groups of patients.

Those differences could eventually be used to help predict which MS treatments will benefit which patients, the study authors said. MS is a neurological disorder in which nerve fiber coatings degenerate, which leads to muscle weakness and possible paralysis.

The findings appeared in the Jan. 14 online issue of the Archives of Neurology and were expected to be published in the March print issue of the journal.

"The beneficial outcomes of interferon beta therapy for patients in the relapsing-remitting phase of MS have been clearly shown," the researchers wrote. "On the other hand, the effect of this treatment is partial, and a substantial amount of patients (up to 50 percent) are not responders. Hence, in the absence of prognostic clinical, neuroradiological and/or immunological markers of response, the question remains who and when to treat when adverse effects, inconvenience and the cost of drugs are significant."

More research is needed to fully predict MS treatment outcomes based on patient DNA analysis, the researchers added.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about MS.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Jan. 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Congressional Budget Office Analysis of HR971 Rejects Pharmacy Benefit Managers Bogus Claim Bill Would Cost $29 Billion Over 5 Years
2. PCMA: New CBO Analysis Confirms Independent Pharmacy Collective Bargaining Legislation Increases Costs for Consumers and Payors
3. Working with children with autistic spectrum disorder: Psychoanalysis and neurobiology
4. Uses of medications in psychoanalysis
5. First rigorous analysis defines impact of Medicare Part D
6. Updated Analysis of 2001 Epoetin Alfa Study Posted
7. Biolytix to Offer Industrial Gene Expression Analysis and Genotyping Services Using Affymetrix GeneChip(R) Technology
8. Ranking Americas Mental Health: An Analysis of Depression Across the States
9. Amarin Announces Completion of Comprehensive Data Analysis From Phase III Huntingtons Disease Program
10. Long-term pharmacotherapy for obesity and overweight: updated meta-analysis
11. Center For Excellence to Fund Analysis of Michigan State Retiree Health Care Reforms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Ill. (PRWEB) , ... October ... ... Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer ... healthcare professionals on guideline updates for the primary prevention of cardiovascular diseases ...
(Date:10/13/2017)... CT (PRWEB) , ... October 13, 2017 , ... ... long-term care services, staged a mock evacuation of the facility as part of a ... Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as ...
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out ... free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting ... children of all ages; it is a non-competitive, non-timed event, which is all about ...
(Date:10/13/2017)... ... 2017 , ... Talented host, actor Rob Lowe, is introducing ... new episode of "Success Files," which is an award-winning educational program broadcasted on ... subject in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... AVACEN Medical , Inc. (AVACEN) announced that ... New Product Innovation Award for Its fibromyalgia pain management ... medical device market research by Frost & Sullivan,s industry experts. ... pain relief product, the AVACEN 100, offers a safe and ... pain. ...
(Date:10/11/2017)...  Caris Life Sciences ® , a leading innovator ... precision medicine, today announced that St. Jude Medical Center,s ... (POA) as its 17 th member. Through participation ... Cancer Institute will help develop standards of care and ... making cancer treatment more precise and effective. ...
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
Breaking Medicine Technology: