Navigation Links
DNA Analysis Could Help Customize Treatments for MS

Study suggests it could show who will respond best to interferon beta treatments

WEDNESDAY, Jan. 16 (HealthDay News) -- Genetic differences might explain why some multiple sclerosis (MS) patients respond to treatment while others don't, suggests an international study.

Starting with 206 southern European patients with relapsing-remitting MS, the most common form of the disease, the researchers compared the DNA of patients whose symptoms were reduced by interferon beta therapy to the DNA of those who experienced relapses after such therapy. They were able to identify important genetic differences between the two groups of patients.

Those differences could eventually be used to help predict which MS treatments will benefit which patients, the study authors said. MS is a neurological disorder in which nerve fiber coatings degenerate, which leads to muscle weakness and possible paralysis.

The findings appeared in the Jan. 14 online issue of the Archives of Neurology and were expected to be published in the March print issue of the journal.

"The beneficial outcomes of interferon beta therapy for patients in the relapsing-remitting phase of MS have been clearly shown," the researchers wrote. "On the other hand, the effect of this treatment is partial, and a substantial amount of patients (up to 50 percent) are not responders. Hence, in the absence of prognostic clinical, neuroradiological and/or immunological markers of response, the question remains who and when to treat when adverse effects, inconvenience and the cost of drugs are significant."

More research is needed to fully predict MS treatment outcomes based on patient DNA analysis, the researchers added.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about MS.

-- Robert Preidt

SOURCE: JAMA/Archives journals, news release, Jan. 14, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Congressional Budget Office Analysis of HR971 Rejects Pharmacy Benefit Managers Bogus Claim Bill Would Cost $29 Billion Over 5 Years
2. PCMA: New CBO Analysis Confirms Independent Pharmacy Collective Bargaining Legislation Increases Costs for Consumers and Payors
3. Working with children with autistic spectrum disorder: Psychoanalysis and neurobiology
4. Uses of medications in psychoanalysis
5. First rigorous analysis defines impact of Medicare Part D
6. Updated Analysis of 2001 Epoetin Alfa Study Posted
7. Biolytix to Offer Industrial Gene Expression Analysis and Genotyping Services Using Affymetrix GeneChip(R) Technology
8. Ranking Americas Mental Health: An Analysis of Depression Across the States
9. Amarin Announces Completion of Comprehensive Data Analysis From Phase III Huntingtons Disease Program
10. Long-term pharmacotherapy for obesity and overweight: updated meta-analysis
11. Center For Excellence to Fund Analysis of Michigan State Retiree Health Care Reforms
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... “Women have 2 questions when they ... to live?’ The second is, “Will I lose my hair?’” , Carly Klein is ... women with licensed medical professionals to develop personalized hair loss treatment plans. With 10 ...
(Date:10/13/2015)... — , ... ... Association of America (MOAA) will hold its 2015 annual meeting ... a free military career fair; informational seminars; a luncheon featuring ... the Joint Chiefs of Staff; and the Community Heroes Award ...
(Date:10/13/2015)... ... ... The American Institutes for Research ( AIR ) developed a collection of guides ... sexual assault and other trauma. The toolkit, funded by the U.S. Department of Education, ... 21st anniversary. , AIR developed the Safe Place toolkit in ...
(Date:10/13/2015)... ... 13, 2015 , ... "My friend's son suffers from eczema, and he had ... an inventor from Platteville, Colo. "I came up with this kit as a way ... to prevent a child from rubbing or scratching his or her face. This protects ...
(Date:10/13/2015)... , ... October 13, 2015 , ... According to an ... recent study has shown that women who successfully lose weight with a bariatric procedure ... United States each year. The article notes that anywhere from 40 to 50 percent ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 13, 2015  Human Longevity, Inc. (HLI), the genomics-based, ... announced today the launch of the company,s first Health ... the potential to transform healthcare. The inaugural Health Nucleus ... , at HLI,s headquarters facility. More Health Nucleus facilities ... and International cities. --> ...
(Date:10/13/2015)... -- Synapse Biomedical Inc. ( ) reported today that ... use of the NeuRx ® Diaphragm Pacing System ... the United States and patient ... PAS study group met their initial enrollment goal ahead ... expanded the enrollment target to 150 participants.   ...
(Date:10/13/2015)... , Oct. 13 2015 ... addition of the "US & European ... Countries (2010-2021)" report to their offering. ... the addition of the "US & ... 16 Countries (2010-2021)" report to their ...
Breaking Medicine Technology: