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DNA (driver of nicotine addiction)
Date:1/29/2008

binding sites for nicotine on certain brain cells which are known to be activated during the process of addiction.

A second population of ~ 8000 people (whose smoking histories were known) was analyzed in a similar manner, the result again suggesting that variations in these two genes increased risk for heavy smoking. Taken together, these two studies provide convincing proof that variations in the alpha 3 and alpha 5 nicotinic receptor subunit genes play a significant role in risk for nicotine addiction. A previously published paper, using similar methods, also supports this conclusion.

These results suggest two important research activities. First, and foremost, the alpha 3 and alpha 5 nicotinic receptor subunits will be made targets for new smoking cessation medication development programs by pharmaceutical companies. Second, the implicated DNA variants can be used to determine whether they predict ability to quit using the one of the currently available smoking cessation medicines. This personalized medicine approach might allow for more efficient and productive use of those medicines, until improved ones can be created.


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Contact: Wade Berrettini
wadeb@mail.med.upenn.edu
484-432-5836
Molecular Psychiatry
Source:Eurekalert

Page: 1 2

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