Navigation Links
DNA (driver of nicotine addiction)
Date:1/29/2008

Cigarette smoking is the largest preventable source of death and disability in the USA, contributing to ~ 400,000 deaths annually. Despite widespread knowledge of the health dangers, ~ 1 in 8 American adults is a habitual heavy smoker.

For several decades, scientists have known that most of the risk for habitual heavy smoking (smoking a pack each day) is largely influenced by genetics. This conclusion comes from the study of identical and fraternal twins from Scandinavia, North America, Australia and (more recently) China. It has been estimated that ~ 2/3 of the risk to become a heavy habitual smoker is genetic. This does not imply that this genetic risk is due to a single gene. It is known that many genes are involved, each one contributing a small amount of risk.

Finding the individual genes is a considerable challenge, but worth the effort, because it is hoped that the genes conveying risk for heavy smoking could be used to develop new medicines to help people quit. The development of new medicines to help people quit is particularly important, because the existing medications, including nicotine replacement (the patch or gum), bupropion and varenicline are effective in the short-term (several months) for a minority of heavy smokers.

This paper describes the results of a genetic study of 14,000 people, from the USA and Europe, whose smoking histories were known. DNA samples from ~ 6000 people were analyzed at ~ 500,000 known variations in the human genome to determine whether any of these variations predicted cigarettes per day during the period of heaviest smoking for these individuals. The results implicated variations in two genes, both producing brain proteins to which nicotine binds in generating its addicting effects. These two proteins (are their genes) are termed the alpha 3 and alpha 5 nicotinic receptor subunits, so-called because they form (with other nicotinic receptor subunits)
'/>"/>

Contact: Wade Berrettini
wadeb@mail.med.upenn.edu
484-432-5836
Molecular Psychiatry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. AUDIO from Medialink and Commit Lozenge: Wanna Quit Smoking With Therapeutic Nicotine? Just Follow the Directions
2. Nicotine in breast milk disrupts infants sleep patterns
3. Nicotine in Breast Milk Shortens Babys Naptime
4. Initial reaction to nicotine can dictate addiction
5. Rat Study Gets at Root of Nicotine Addiction
6. Nicotine, Chili Peppers Offer Post-Surgery Pain Relief
7. Parkinsons Institute research shows that nicotine reduces levodopa-induced dyskinesias
8. Genes, brain chemistry may dictate nicotine cravings, says CU-Boulder study
9. Nicotine Plus Alcohol May Be Tough to Beat
10. Nicotine addiction slashed in test of new cigarette smoking strategy
11. Nicotine-Reduced Cigarettes Could Boost Quitting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2015)... Women’s Excellence is pleased to announce the addition of ... There are over 75 terms and phrases available for viewing, ... gives our patients a better understanding of what our Providers are ... understand. With this resource, our patients are able to go ... and phrases that they may not remember or comprehend at the ...
(Date:3/1/2015)... York, NY (PRWEB) March 01, 2015 ... and seek insurance rates for term or universal policies ... of some of the best life insurance companies for ... through the system at http://quotespros.com/life-insurance.html . , The ... the search portal are tied to a number of ...
(Date:3/1/2015)... Ticket Down is a reputable source for authentic ... Deadheads have been anxiously anticipating this blockbuster weekend ever ... formed 50 years ago back in the 60s in Palo ... untimely death of Jerry Garcia in 1995. This beloved ... rock, bluegrass, folk, space rock and country to become an ...
(Date:3/1/2015)... 2015 ERISAPros is pleased ... Roddy to the professional staff of its Compliance Department. ... The Ohio State University-Mortiz College of Law. Prior to ... working with several Fortune 500 companies as well as ... corporate benefits. Her experiences range from benefit plan design, ...
(Date:3/1/2015)... 2015 CrossFit Attollo is a CrossFit gym ... a special discount to new members. Now through the ... three month contract will receive their fourth month half off. ... members $440. The three month contract is only $264, ... the fourth month comes in at only $55. The special ...
Breaking Medicine News(10 mins):Health News:Best Life Insurance Companies for Single Adults Now Searchable at Insurance Website 2Health News:Grateful Dead Tickets at Soldier Field in Chicago: Ticket Down Slashes Grateful Dead Ticket Prices in Chicago at Soldier Field for 4th of July Weekend Celebration 2Health News:ERISAPros Recruits Evelyn King, J.D. and Carolyn Roddy, J.D. to its Professional Staff 2Health News:CrossFit Gym in Vancouver WA Offers Spring Special 2
... Canadian researchers report , , FRIDAY, July 18 (HealthDay News) -- ... but researchers report they have been able to do that ... pulses into the brain. , Someone with lazy eye -- ... eye is weaker than the other. Early treatment often has ...
... McCain Is Not What America Signed Up For, ... advisor, Phil Gramm, echoed McCain,s comments that America,s,economic problems ... and that America had become a "nation of whiners." ... is now back on board as,McCain,s top economic adviser. ...
... by a Michigan State University scholar refutes commonly held ... and harder to get along with than their "normal ... to guard against the use of weight-based stereotypes when ... Roehling, associate professor of human resource management, and two ...
... Calif., July 18 Actress and best-selling author,Jenny ... in the search,for an autism cure and advocate ... McCarthy incorporated the Global Health Trax(TM) (GHT) flagship,specialty ... and shared her experience in her book Louder ...
... ease symptoms, but old drug offers new hope , , FRIDAY, ... one step back in the search for treatments against Alzheimer,s ... 19 issue of The Lancet , an older drug ... report, a once-promising vaccine failed to prevent the progression of ...
... Cites Work with Women Veterans, WASHINGTON, July 18 ... Center for Post Traumatic,Stress Disorder (PTSD), received the 3rd ... with PTSD and women veterans., "Dr. Schnurr,s contribution ... to healing those who have borne the battle,",said Secretary ...
Cached Medicine News:Health News:Magnetic Pulses to Brain Improve Lazy Eye in Adults 2Health News:Magnetic Pulses to Brain Improve Lazy Eye in Adults 3Health News:DNC: McCain Watch: The Economy 2Health News:DNC: McCain Watch: The Economy 3Health News:Studies refute common stereotypes about obese workers 2Health News:Global Health Trax Joins Fight Against Autism With Jenny McCarthy and Generation Rescue 2Health News:Alzheimer's Research Brings Progress, Setbacks 2Health News:Alzheimer's Research Brings Progress, Setbacks 3Health News:Alzheimer's Research Brings Progress, Setbacks 4
(Date:3/2/2015)... , March 2, 2015 Valencia Technologies Corporation ... patient with its radically small device for the ... early results in this randomized, double-blinded, controlled trial are ... of confidence that it will succeed in a large ... early clinical results, Valencia has ...
(Date:3/2/2015)... 2015 Following announcements from both Novartis ... BioPharma Inc. (NASDAQ:  ARRY) today announced the completion ... with Novartis.  Along with global ownership of both ... $85 million from Novartis. Ron Squarer, ... of the Novartis-GSK transaction, Array now owns both ...
(Date:3/2/2015)... , March 2, 2015  Galmed Pharmaceuticals Ltd. (Nasdaq: ... focused on the development and commercialization of a once-daily, ... cholesterol gallstones, today announced that Josh Blacher , ... the 27th Annual ROTH conference in Laguna ... at 2:30 PM Pacific Standard Time. A live webcast ...
Breaking Medicine Technology:Valencia Technologies Implants its 48th Patient, Continues Equity Crowdfunding 2Array Announces Completion Of Binimetinib And Encorafenib Transactions 2Array Announces Completion Of Binimetinib And Encorafenib Transactions 3Array Announces Completion Of Binimetinib And Encorafenib Transactions 4Array Announces Completion Of Binimetinib And Encorafenib Transactions 5Galmed Pharmaceuticals to Present at the 27th Annual ROTH Conference 2
... , SAN ... marketer of the VerifyNow® System, the first rapid and easy-to-use ... agents (e.g. Plavix® and aspirin), announced today that Timothy I. ... Chief Financial Officer of Accumetrics, will be presenting a corporate ...
... , RALEIGH, N.C., Nov. 24 ... for the pharmaceutical and biotech industry, today announced the launch ... The new Hospital Marketplace e-course is the newest ... a comprehensive series of e-courses designed to fill the critical ...
Cached Medicine Technology:Accumetrics to Present at the 21st Annual Piper Jaffray Health Care Conference 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 3
DMSO-resistant microplate sealing film...
Amplification Tape 96 featuring 3M adhesive technology. Good optical quality. Minimal autofluorescence. Certified RNase and DNase free....
Empore Sealing Tape Pads are ideal for covering a 96 well plate during storage or transfer to another work station. Not intended for use with auto-injectors....
... Microseal 'B' seals provide an adhesive-based ... microplates. The aggressive adhesive layer ensures secure ... cycling, and tight sealing during thermal cycling ... heated lid. The perforated end-tabs can be ...
Medicine Products: