Navigation Links
DFMO may affect Barrett's esophagus
Date:11/16/2008

"While there was a suggestion that DFMO may influence the extent of Barrett's dysplasia, this finding is very preliminary and further study of this agent in a larger number of patients is needed," said Frank A. Sinicrope, M.D., professor of medicine and oncology at the Mayo Clinic, Rochester, MN.

Sinicrope presented his findings here at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.

The single-arm study included 10 patients with Barrett's esophagus and low-grade dysplasia. The patients received 0.5 g/m2/d of DFMO for six months. Using an endoscope, the researchers examined esophageal biopsies at enrollment and at three, six and 12 months (where available). A gastrointestinal pathologist who was blinded to the clinical/biomarker data graded the dysplasia.

Sinicrope conducted this study while at The University of Texas M. D. Anderson Cancer Center. He collaborated with colleagues at the National Cancer Institute, and the Arizona Cancer Center, Tucson.

After six months of DFMO treatment, one patient's dysplasia regressed, one patient's progressed, and eight patients had stable disease. At six months, two patients in the stable group who started with extensive low-grade abnormal cells had only limited or focal dysplasia based on four or more biopsies. These improvements remained at 12 months.

DFMO lowered the level of the polyamine putrescine, a target of the drug and a possible cancer risk marker. The agent works by inhibiting an enzyme in polyamine synthesis called ornithine decarboxylase (ODC). "ODC activity in Barrett's mucosa has been shown to be significantly higher in Barrett's than in normal adjacent mucosa from the same patients," Sinicrope said. "Since DFMO inhibits polyamine synthesis, the fact that putrescine levels were decreased at six months and later returned to baseline after being off the drug for six months suggests
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. American Academy of Dermatology: How You Feel on the Inside Could be Affecting How You Look on the Outside
2. Past gains in reducing risk of heart disease have flattened, women especially affected
3. Governor Mike Huckabee Discusses How President Elect Barack Obamas Approach to Health Care Will Affect the Nation
4. Gene Mutation May Cause Some Cases of Seasonal Affective Disorder
5. New Treatment Options for Seasonal Affective Disorder, from Harvard Mental Health Letter
6. Impulse control area in brain affected in teens with genetic vulnerability for alcoholism
7. Folic acid, B vitamins do not appear to affect cancer risk
8. ADHD Affects Movement More in Boys Than in Girls
9. Study finds ADHD affects motor skills of boys more than girls
10. Consuming small amounts of caffeine when pregnant may affect the growth of an unborn child
11. Media Affects Public Perception of Infectious Diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... UT (PRWEB) May 23, 2013 ... a comprehensive radiology learning environment for all resident ... lessons and assessments, transforms the learning experience from ... curriculum. , “Until RADPrimer 3.0, RADPrimer ... to none,” comments Dr. B.J. Manaster, Professor of ...
(Date:5/23/2013)... May 23, 2013 Memorial Day Focus ... Chaplains have been a part of the U.S. Military ... like those preceding it, these men and women will ... United States of America. As veterans transition to ... migration to the workplace chaplaincy world. , Marketplace ...
(Date:5/23/2013)... Susquehanna Health is now a ... training course for adolescents age 11 and up. ... Dr. Patricia Keener after a colleague’s toddler choked to ... who didn’t know how to provide first aid. Safe ... medical basis that aims to reduce the number of ...
(Date:5/23/2013)... used next generation genomic analysis to determine that some ... genetic origins, which may help in predicting cancer progression. ... Cancer Research . , "This is the first study ... adjacent Gleason patterns in the same tumor allowing us ... Cheville, M.D., Mayo Clinic pathologist and one of the ...
(Date:5/23/2013)... 2013 Dr. Katherine Ahn is ... in Orange County, OCCares , will hold its first ... The event details are as follows: , Sunday May 26th, ... Clinton Street, Garden Grove, CA 92843 , The benefit celebration ... Christian vocalists Charmaine & Jonathan Thulin. There will also ...
Breaking Medicine News(10 mins):Health News:RADPrimer 3.0 Introduces Comprehensive Radiology Training Curriculum 2Health News:Memorial Day Focus Spotlight on Military Chaplains Transitioning in the Marketplace 2Health News:Memorial Day Focus Spotlight on Military Chaplains Transitioning in the Marketplace 3Health News:Susquehanna Health Offers Safe Sitter Course for Tweens and Teens 2Health News:Susquehanna Health Offers Safe Sitter Course for Tweens and Teens 3Health News:Mayo Clinic genomic analysis lends insight to prostate cancer 2Health News:Dr. Katherine Ahn is Proud to Announce the Launch Her Family's New Charity OCCares 2Health News:Dr. Katherine Ahn is Proud to Announce the Launch Her Family's New Charity OCCares 3
... osteoporosis is useful, but changes in bone// mineral density ... anti-resorptive agents that prevent bone breakdown. ,For patients ... enhances bone formation is preferable, and this is now ... However, the use of PTH is limited by its ...
... University of Bath in England an interesting study has been ... men. This is despite the popular notion that the ... yet knows. ,“Until fairly recently it was controversial to suggest ... the perception and experience of pain, but that is no ...
... issue of the journal Thorax, researchers have emphasized// the ... into the data provided by 2401 subjects who had ... incidence of tuberculosis disease. Of the total subjects ... test. The research results have showed that the increase ...
... it will promote a culture of openness and enhanced// ... FDA will create a new independent Drug Safety Oversight ... and will provide emerging information to health providers and ... ,Specific proposals for immediate and fundamental steps to improve ...
... journal Thorax a study concludes that smoking may increase ... at 2,401 adults from two urban communities in Cape Town, ... and underwent a tuberculin skin test. Factors such as age, ... into account. ,Of 1,309 current smokers or ex-smokers, ...
... Drug Administration (FDA) today issued a public health advisory ... the suspended marketing of Tysabri (nataluzimab) while the agency ... with its use., ,Tysabri, which received accelerated approval ... that represents a new approach to treating patients with ...
Cached Medicine News:Health News:The Benefits of Strontium in the treatment for Osteoporosis Questioned 2Health News:Gender difference in Pain Experience - Women feel More Pain than men 2Health News:Monitoring Drug Safety 2Health News:FDA Issues Public Health Advisory on Tysabri, a New Drug for MS 2
(Date:5/23/2013)... May 23, 2013  The need to add ... continuum was highlighted prominently at the 108 th ... (AUA), in San Diego.  According to SonaCare Medical, ... ultrasound (HIFU) technology, the need for image-guided technologies ... urologists to consider minimally invasive ablative treatments, was ...
(Date:5/23/2013)...  Every day, their baby stopped breathing, his collapsed bronchus ... April and Bryan Gionfriddo watched helplessly, just ... "Quite a few doctors said he had a good chance ... Gionfriddo , about her now 20-month-old son, Kaiba. "At ... would take it and run with it." They ...
(Date:5/23/2013)... 2013  Hologic, Inc. (Hologic or the Company) ... manufacturer and supplier of premium diagnostics, medical imaging ... serving the healthcare needs of women, today announced ... U.S. clinical practice comparing breast cancer screening with ... 2D mammography alone showed a significant reduction in ...
Breaking Medicine Technology:Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 3Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 4First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4
... rate: 80 cc/minute. Pore ... filtering fluids at flow ... bi-directional membrane support rated ... psi) via prefilled syringe ...
4 mm x 4 mm downward biting jaws, curved right, length of shaft 115 mm, overall length 9.3 inches....
Straight, right side cutting, 1.5 mm x 4 mm bite, length of shaft 115 mm, overall length 6.3 inches....
Backward cutting, 3 mm x 7 mm bite, length of shaft 100 mm, overall length 7 inches....
Medicine Products: