Navigation Links
DDT Compound Speeds Breast Cancer Growth
Date:2/14/2008

Insecticide metabolite disrupts hormone-sensitive cells, study finds

THURSDAY, Feb. 14 (HealthDay News) -- A new Canadian study may finally explain how a key compound found in the U.S.-banned insecticide DDT accelerates the growth of breast cancer tumors.

The new report, published in the open access journal Breast Cancer Research, suggests that DDT's main metabolite blocks a pathway of a hormone that would otherwise help inhibit growth in normally responsive breast cancer cells.

In their study, researchers from Universite Laval and Institut national de sant publique in Quebec found that the metabolite blocked the androgen receptors (AR) found on certain human breast cancer cells.

When added to cancer cells having AR, potent androgen compounds slow the tumor's growth. But the researchers found that when increasing concentrations of the metabolite were added, the androgen-mediated effects were blocked. The growth of breast cancer cells known as CAMA-1 actually accelerated, even when androgen was present to try to mitigate the presence of the hormone estrogen, which normally signals the cancer cells to grow.

"Our results suggest that in addition to estrogenic compounds, which have been the main focus of researchers over the past decades, chemicals that block the AR could favor breast cancer progression," lead researcher Pierre Ayotte said in a prepared statement.

DDT, a widely used insecticide in the United States from World War II through the 1970s, has been linked to breast cancer in previous studies. It was banned stateside following concerns about its affects on wildlife, the environment and human health, but it is still used in some other countries.

More information

Learn more about the role of hormones and breast cancer through the nonprofit organization breastcancer.org.



-- Kevin McKeever



SOURCE: BioMed Central, news release, Feb. 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel compound may lessen heart attack damage
2. Grapefruit compound may help combat hepatitis C infection
3. Research discovers new compounds active against tuberculosis and malaria
4. Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer
5. Francks Compounding Lab Purchases Wisconsin Pharmacy
6. BioSeek Initiates Systems Biology Compound Evaluation Collaboration with UCB
7. PharMEDium Announces Availability of Pre-Filled Operating Room Perioperative Compounded Drugs
8. Bionovo Describes a New Class of Therapeutic Compounds
9. Novel Compounds May Battle Diseases of Aging
10. Pharmacopeia and GlaxoSmithKline Collaboration Identifies Two Additional Lead Compounds
11. Prostate Cancer Treatments Often Compound Existing Health Problems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DDT Compound Speeds Breast Cancer Growth
(Date:8/19/2017)... ... August 19, 2017 , ... “Congratulations! It's A Boy! ... children to both their parents and God. “Congratulations! It's A Boy! God’s Gift: A ... a couple from Long Island, New York. , Published by Christian Faith Publishing, Dale ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... specialized asset-light logistics provider of complex transport solutions for mission-critical and non-discretionary ... Unitrans International Corporation, a division of Roadrunner Transportation Systems, Inc. (NYSE: RRTS). ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... handheld devices. Through an educational webinar, they will present the line of epMotion ... to learn how easy you can automate everyday pipetting tasks. , Ideal for ...
(Date:8/18/2017)... TX (PRWEB) , ... August 18, 2017 , ... ... assistance and financial planning services to communities in east Texas, is launching a ... Brain Tumor Foundation. , Founded in 1991, the Pediatric Brain Tumor Foundation (PBTF) ...
(Date:8/18/2017)... ... 2017 , ... The Golseth Agency, a Texas based insurance management and financial ... regional charity campaign organized to provide support to Christina Upchurch and her two children ... and her children returned from out of town to find her husband passed away ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... HIGH POINT, N.C. , Aug. 15, 2017  Axium Pharmaceuticals Inc., ... epilepsy is rumored to be in the beginning stages of an IPO. ... billion annually on epilepsy medications with the average cost of a prescription ... ... Another staggering figure is ...
(Date:8/11/2017)... Israel , Aug. 11, 2017 DarioHealth ... with mobile health and big data solutions, today announced ... on Monday, August 14 and host a conference call ... quarter 2017 operating and financial results and its strategy ... will be hosted by Erez Raphael , Chief ...
(Date:8/7/2017)... , Aug. 7, 2017 Insightin ... member acquisition, retention, and engagement, announced the selection ... Strategy and Product Development, effective as of February 2017. ... and technology implementation strategy for our clients. Wood ... experience in consulting and business analytics within the ...
Breaking Medicine Technology: