Navigation Links
DDT Compound Speeds Breast Cancer Growth
Date:2/14/2008

Insecticide metabolite disrupts hormone-sensitive cells, study finds

THURSDAY, Feb. 14 (HealthDay News) -- A new Canadian study may finally explain how a key compound found in the U.S.-banned insecticide DDT accelerates the growth of breast cancer tumors.

The new report, published in the open access journal Breast Cancer Research, suggests that DDT's main metabolite blocks a pathway of a hormone that would otherwise help inhibit growth in normally responsive breast cancer cells.

In their study, researchers from Universite Laval and Institut national de sant publique in Quebec found that the metabolite blocked the androgen receptors (AR) found on certain human breast cancer cells.

When added to cancer cells having AR, potent androgen compounds slow the tumor's growth. But the researchers found that when increasing concentrations of the metabolite were added, the androgen-mediated effects were blocked. The growth of breast cancer cells known as CAMA-1 actually accelerated, even when androgen was present to try to mitigate the presence of the hormone estrogen, which normally signals the cancer cells to grow.

"Our results suggest that in addition to estrogenic compounds, which have been the main focus of researchers over the past decades, chemicals that block the AR could favor breast cancer progression," lead researcher Pierre Ayotte said in a prepared statement.

DDT, a widely used insecticide in the United States from World War II through the 1970s, has been linked to breast cancer in previous studies. It was banned stateside following concerns about its affects on wildlife, the environment and human health, but it is still used in some other countries.

More information

Learn more about the role of hormones and breast cancer through the nonprofit organization breastcancer.org.



-- Kevin McKeever



SOURCE: BioMed Central, news release, Feb. 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel compound may lessen heart attack damage
2. Grapefruit compound may help combat hepatitis C infection
3. Research discovers new compounds active against tuberculosis and malaria
4. Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer
5. Francks Compounding Lab Purchases Wisconsin Pharmacy
6. BioSeek Initiates Systems Biology Compound Evaluation Collaboration with UCB
7. PharMEDium Announces Availability of Pre-Filled Operating Room Perioperative Compounded Drugs
8. Bionovo Describes a New Class of Therapeutic Compounds
9. Novel Compounds May Battle Diseases of Aging
10. Pharmacopeia and GlaxoSmithKline Collaboration Identifies Two Additional Lead Compounds
11. Prostate Cancer Treatments Often Compound Existing Health Problems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DDT Compound Speeds Breast Cancer Growth
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
(Date:6/24/2016)... San Diego, CA (PRWEB) , ... June 24, 2016 , ... ... up with the American Cancer Society and the Road To Recovery® program to drive ... care to seniors and other adults to ensure the highest quality of life and ...
(Date:6/24/2016)... Norcross, Georgia (PRWEB) , ... June 24, 2016 ... ... Year” awards today at the Clinical Decision Making in Emergency Medicine conference in ... who have authored journal articles published in Emergency Medicine Practice and ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... for human induced pluripotent stem (iPS) cells and other difficult to transfect cells, ... Cloning Medium. The PluriQ™ G9™ Gene Editing System is a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
Breaking Medicine Technology: