Navigation Links
DCIS patients who get invasive breast cancer have higher mortality
Date:3/11/2011

Women with ductal carcinoma in situDCISwho later develop invasive breast cancer in the same breast are at higher risk of dying from breast cancer than those who do not develop invasive disease, according to a study published online March 11 in the Journal of the National Cancer Institute.

Retrospective studies of women with DCIS have compared breast conserving surgery (lumpectomy) to mastectomy and found that survival rates are similar. However, women who have lumpectomy alone, without further treatment, are at higher risk of developing invasive breast cancer in the same breast. Whether women who develop invasive breast tumors after DCIS are also at higher risk of dying of breast cancer has not been clear.

To explore this question as well as the long-term effects of treatments aimed at avoiding invasive recurrence after lumpectomy, Irene Wapnir, M.D., of Stanford University School of Medicine, and James Dignam, PhD of University of Chicago looked at the long-term outcomes of patients with localized DCIS who took part in two large randomized trials, both carried out by the National Surgical Adjuvant Breast and Bowel Project (NSABP). The B-17 trial compared lumpectomy alone to lumpectomy plus radiation therapy in women with DCIS. The B-24 trial compared lumpectomy plus radiation in combination with either tamoxifen or placebo.

Wapnir and colleagues analyzed data on outcomes in both trials after 15 years, including overall and breast cancer-specific survival and survival after development of invasive breast cancer in the same, or ipsilateral, breast.

They found that the development of invasive ipsilateral breast cancer was associated with death rates that were statistically significantly higher than those in women who did not develop an invasive ipsilateral breast cancer. Recurrence of DCIS was not associated with higher mortality. Radiation treatment after lumpectomy reduced the risk of ipsilateral invasive breast cancer compared to lumpectomy alone, and treatment with radiation and tamoxifen reduced the risk compared to radiation only. The reductions in risk were statistically significant.

Among all patients in the trials, the 15-year cumulative incidence of death from breast cancer was 4.7% or less for all treatment groups. Some of these events could be attributed to new invasive contralateral breast cancers.

The authors conclude that, regardless of treatment, women with DCIS have an excellent overall prognosis "despite persistent risks of breast cancer in the same or contralateral breast." They note that three other NSABP trials now in progress will provide more information on other treatment options following lumpectomy.


'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. 70 percent of prostate cancer patients on ADT gain significant weight in first year
2. Research suggests HIV-infected patients at higher risk for bone fractures
3. Hopkins Childrens study finds some patients with cerebral palsy have asymmetric pelvic bones
4. Study: Homeless patients cost $2,500 more than the average patient for each hospital stay
5. Family Involvement Helps Stroke Patients With Rehab
6. University of Michigan Cardiovascular Center studies new treatment for high-risk aortic patients
7. Abnormal neural activity recorded from the deep brain of Parkinsons disease and dystonia patients
8. Hospitals Urged to Check for Depression Before Discharging Heart Patients
9. Epilepsy-linked memory losss worries more patients than doctors
10. Cancer in HIV-positive patients
11. HBV infection decreases risk of liver metastasis in colorectal cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... 2017 , ... Catalent Pharma Solutions, the leading global provider ... products, today announced that Mr. Michael Merges, Director of Strategic Growth, Catalent Biologics ... at the Mayflower Hotel, Washington DC, on Jan. 24 – 26, 2017. , ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... the first time support an aid project with the donation of cochlear implants. ... the gift of hearing and thus a fair chance of leading an independent ...
(Date:1/18/2017)... CA (PRWEB) , ... January 18, 2017 , ... ... dental problems ranging from gum disease to enamel erosion, and those dental problems ... Massachusetts Department of Public Health, many pregnant women are failing to get the ...
(Date:1/17/2017)... ... January 17, 2017 , ... January is National Stalking Awareness Month (NSAM), ... lurk in the corners and commit the crime of stalking, a very real danger to ... an often overlooked factor in stalking and other crimes. , “Stalking: know it. Name it. ...
(Date:1/17/2017)... ... 2017 , ... Gym Source, America’s leading retailer of premium residential and commercial ... in Miami, FL. , “We are elated to be opening this new showroom,” explains ... designed to give clients a seamless and motivating shopping experience.” , Every fitness journey ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... HARRISBURG, Pa. , Jan. 17, 2017 ... Drug and Alcohol Programs Secretary Gary Tennis ... with carfentanil, following two recent overdose deaths from the ... "Carfentanil is intended to sedate large animals ... potentially kill anyone who comes into contact with it," ...
(Date:1/17/2017)... EU5 Glucose Monitoring Market Outlook to 2022 ... Monitoring Market Outlook to 2022", provides key market data ... value, in millions of US dollars, volume (in units) ... Glucose Meters, Blood Glucose Test Strips and Lancets. ... data for each of these market segements, and global ...
(Date:1/17/2017)... 2017 The interventional radiology products market is ... USD 6.35 billion in 2016, at a CAGR of ... this market are rising incidence of chronic diseases, rising ... The global interventional radiology products market is ... the basis of type, the stents segment is expected ...
Breaking Medicine Technology: