Navigation Links
DCIS Score quantifies risk of IBE
Date:5/2/2013

The ductal carcinoma in situ (DCIS) Score quantifies the risk of ipsilateral breast event (IBE) and invasive IBE risk, complements both traditional clinical and pathologic factors, and helps provide a new clinical tool to improve the process of selecting individualized treatment for women with DCIS who meet the criteria, according to a study published May 2 in the Journal of the National Cancer Institute.

Most women with newly diagnosed cases of DCIS are eligible for breast conservation surgery, either with radiation treatment or without. The risk of developing IBE after surgical excision without radiation has not been well defined by clinical and pathological characteristics for women with DCIS.

In order to determine the risk of developing IBE after surgical expression without radiation for women with DCIS, Lawrence J. Solin, M.D., of the Department of Radiation Oncology at the Albert Einstein Medical Center in Philadelphia and colleagues looked at the Oncotype DX breast cancer assay which was used for patients with DCIS, treated with surgical excision without radiation in the Eastern Cooperative Oncology Group (ECOG) E5194 study, and looked at the association between the DCIS Score and the risk of developing IBE.

The researchers found that the continuous DCIS Score was statistically significantly associated with the risk of developing IBE. "The DCIS Score predicts the risks of local recurrence and invasive local recurrence and provides information that complements traditional clinical and pathologic factors for this study population of women with DCIS treated with surgical excision without radiation."

In an accompanying editorial, Christine D. Berg, M.D., formerly of the National Cancer Institute, writes that the assay does appear to be a step forward, but there were limitations, including that it was tested in a selected subset of patients. "The clinical applicability of this assay for all women who present with DCIS remains to be determined as the research was done on a highly selected patient group."

In another editorial, Thomas B. Julian, M.D., of Allegheny General Hospital in Pittsburgh, writes that the study and team should be applauded for efforts in introducing the DCIS score with an attempt to validate risk recurrence in patients with DCIS using tumor genetic profiling. "The DCIS Score should complement traditional clinical and pathologic factors used to guide decision making in the treatment of DCIS."


'/>"/>

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Best 2013 Colorado Burglar Alarm System Companies Scored by 6Webs.com
2. Best 2013 California Home alarm System Companies Scored by 6Webs.com
3. New scorecard shows inequalities in osteoporosis care in the Europe Union
4. NIST tests underscore potential hazards of green laser pointers
5. Validated pre-procedure risk score reduces bleeding complications and can shorten stays
6. Scores that evaluate newborn intensive care units are inconsistent
7. Zephanol-HP Takes Top Scores in Newly-Released Independent Diet Pill Research
8. Liproxenol is First Diet Pill to Earn Perfect Score from Independent Review Organization
9. New Study Finds Eating More Colorful Produce May Prevent or Delay ALS, Underscores Value of Health Enhancement Systems Program Design
10. Independent Research Shows That Medrio, a Leading EDC and eClinical SaaS Provider for Clinical Research, Continues to Achieve Exceptional Scores in Customer Satisfaction
11. GuardianHelmets.com Scores High Marks on B.R.A.I.N.First Certification™
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Coast Dental ... February is National Children’s Dental Health Month and family dentist Yvonne Dorrian, DMD, is ... at Coast Dental , located next to Target at 1207 North Peachtree Parkway ...
(Date:2/8/2016)... New York, NY (PRWEB) , ... February 08, 2016 , ... ... handles are too much to handle, you are not alone. According to the Center ... conditions include heart disease, stroke, type 2 diabetes and certain types of cancer, some ...
(Date:2/8/2016)... ... 2016 , ... Delta Dental of California and its affiliated companies announced today ... Radine, who recently retired as president and CEO of Delta Dental of California and ... the Year , helped lead the effort to raise funds for studies to strengthen ...
(Date:2/8/2016)... ... February 08, 2016 , ... Discover the Rocky Mountain ... 1,400 booths and 700 companies. Attendees also get to see the most incredible ... Garden & Home Show , at the Colorado Convention Center - 700 14th St. ...
(Date:2/8/2016)... ... February 08, 2016 , ... Guruji Mahendra Kumar Trivedi is offering ... 2016 in honor of his birthday on February 10th. During this time, people ... is known by over 250,000 people from over 40 different countries as an “ordinary ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016  Echo ... medical device company focused on non-invasive continuous ... announced today announced that it will host ... February 17, 2015 at 9:00 a.m. Eastern ... discuss its corporate strategy, advancements in its ...
(Date:2/8/2016)... Feb. 8, 2016 Nueterra, the ... specialized in the development of equity partnerships ... it has divided its interests between two ... Capital will continue the founding company,s private ... operate a national system of integrated provider ...
(Date:2/8/2016)... Intarcia Therapeutics, Inc. today announced the appointment of ... created role of Vice President, Head of Global Medical ... of leadership experience at leading pharmaceutical, biotechnology, and health ... Most recently Dr. Yee served as VP, Head of ... Officer at AstraZeneca, where he led medical affairs across ...
Breaking Medicine Technology: