Navigation Links
DCA research on brain cancer
Date:5/12/2010

Edmonton, AB Medical Researchers at the University of Alberta reported today evidence that the orphan generic drug Dichloroacetate (DCA) may hold promise as potential therapy for perhaps the deadliest of all human cancers: a form of brain cancer called glioblastoma. The report is published at the journal Science Translational Medicine, a journal of the American Association of the Advancement of Science; it appears today at the journal's web site http://www.sciencemag.org/

In 2007 the U of A team led by Dr. Evangelos Michelakis, published evidence that DCA reverses cancer growth in non-human models and test tubes. The team showed then that DCA achieves these antitumor effects by altering the metabolism of cancer. By altering the way cancer handles its nutrient fuels, specifically the sugars, DCA was able to take away cancer's most important strength, the resistance to death. Since then, several independent groups across the world have confirmed the Alberta team's findings. In December 2009, the editors of "Science" predicted that cancer metabolism is one of only 5 areas across all scientific disciplines, to "watch for major breakthroughs" in 2010.

The U of A team set out to show that the way that DCA works in actual patients is the same with the way it works in the lab. In addition, researchers wanted to show whether DCA is safe and possibly effective in very sick patients with brain cancer.

By extracting glioblastomas from 49 patients over a period of 2 years and studying them within minutes of removal in the operating room, the team showed that tumors respond to DCA by changing their metabolism. Then, the team treated 5 patients with advanced glioblastoma and secured tumor tissues before and after the DCA therapy. By comparing the two, the team showed that DCA works in these tumors exactly as was predicted by test tube experiments. This is very important because often the results in n
'/>"/>

Contact: Noreen Remtulla
noreen.remtulla@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. The International Meeting for Autism Research (IMFAR)
2. OUHSC receives $100,000 Grand Challenges Explorations grant for innovative global health research
3. Cost Savings from Mobile Health Monitoring to Reach $1.9 billion to $5.8 Billion Globally by 2014 says Juniper Research
4. Trans-Atlantic agreement a boost to neuroscience research
5. Researchers discover new way to rescue treatment sensitivity of breast cancer cells
6. Georgetown Research Center Helps Reporters Decipher Health Reform Law & Impact on State Residents
7. Mild-mannered metabolic helper rushes to fight invading viruses, researchers report
8. Mayo-led research team develop agents that keep insulin working longer
9. UT Southwestern researchers uncover Fragile X syndrome genes role in shaping brain
10. Brains master switch is verified by Iowa State University researcher
11. Accumed Research Associates Expands Capabilities In Phase I and Bioequivalence Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Dec. 24, 2014 (HealthDay News) -- Among early stage ... less than half of one percent will eventually develop ... analysis reveals. The finding comes from a review ... 1998 and 2007, and it suggests that the risk ... what experts had previously thought. "The frequency of ...
(Date:12/25/2014)... AngelWeddingDress.com tries its best to translate the experience ... business has introduced its new collection of 2015 prom ... The new prom outfits are guaranteed to contain the ... are specially designed for 2015. Anyone who wants to ... its website before Jan. 26, 2015, the deadline of ...
(Date:12/25/2014)... 25, 2014 “ SmileStix ” was featured ... the latest and coolest mobile applications on the iOS, Android, ... host of NewsWatch, conducted the app review and shared with ... personal stickers. , The old saying goes, “A picture says ... words that can describe a single image, because each picture ...
(Date:12/25/2014)... 25, 2014 Residents at ... recently showed their generous spirit by providing holiday ... County Parenting Network- Grandparents Raising Grandchildren program. , ... around the largest Christmas tree on the campus ... by residents of the Abernethy Village Association (AVA). ...
(Date:12/25/2014)... 2014 Parker & Sons, Inc. an ... and affordable quality regarding heating, cooling and plumbing services ... 2014 by the “Queen of Clean” for impressive contractor ... impressive reputation over the years for providing outstanding quality ... of contractor services for both homeowners and businesses. Linda ...
Breaking Medicine News(10 mins):Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3
... when she was four months pregnant, had been proclaimed //as ... had given birth to a two-month premature daughter, while being ... Hospital Center in Arlington had kept her on the machines ... the sake of her unborn child. Susan was admitted to ...
... can now be treated effectively with cognitive //therapy programs. ... than the other treatments used for treating people with ... current issue of JAMA. ,Researchers from the University ... to determine whether a brief psychosocial intervention could reduce ...
... August 1, 2005 (New Delhi): The Union Health Minister of India, ... ,"There is no epidemic alert as of now," said ... floodwaters are yet to recede in many parts// of the city ... ,Ramdoss says that the state health machinery is taking ...
... in children has been linked to the health condition ... report is published //in the new edition of the ... prevalence of childhood obesity has doubled in the past ... diabetes mellitus (T2DM) and potentially devastating cardiovascular disease (CVD) ...
... Graduates (ATMG) of the US has given $110,000 in aid ... ,The ATMG-run Charitable Foundation collected the money from about 5,000 ... received $50,000 to be spent on tsunami relief. The other ... Kumarasamy Health Centre in Kanyakumari and Serve The Helpless. ...
... all you have ever heard about eating sensibly and exercising. ... to fast one day and feast// the next - the ... could revolutionise conventional wisdom about nutrition and dieting, is the ... the National Institute on Ageing here., ,For several years ...
Cached Medicine News:Health News:Suicidal Tendencies May Be Treated With Cognitive Therapy 2Health News:‘No Epidemic Risk in Mumbai’ Assures Health Ministe 2Health News:Size Of The Waist In Children Linked To Diabetes 2Health News:Fasting, Feasting Your Way To Health 2
(Date:12/24/2014)... CHAPEL HILL, N.C. , Dec. 23, 2014 /PRNewswire/ ... marketplace success. As the key link between the medical ... will grow even more in the coming years as ... relationships. According to research by benchmarking ... and MSLs can gain an important edge is by ...
(Date:12/22/2014)... Dec. 22, 2014 Apnea Sciences ( www.apneasciences.com ... in Aliso Viejo , California.  ... the tremendous growth and worldwide expansion, a new facility ... SnoreRx, the anti snore cure have exceeded our expectations ... "We are now in 23 countries and will be ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... addition of the "Investment Analysis of the ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... the US medical device sector identifies the key ... venture capital investments, and mergers and acquisitions. ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2Investment Analysis of the US Medical Device Sector 2
... Surgical, Inc. today announced that the U.S. Patent ... for another key patent application, "Mechanical Method and ... subject matter covering the method of the INSORB ... Company has now sold over 500,000 INSORB® Absorbable ...
... Diversifies Revenue Streams and Boosts Scale in Existing ... Transaction Expected to be Immediately Accretive to Adjusted Diluted Earnings ... Company Reiterates Full-Year 2010 Financial Guidance ... announced today that it has entered into a definitive agreement ...
Cached Medicine Technology:Incisive Surgical Issued Notice of Allowance for Key Absorbable Skin Stapler Patent 2Incisive Surgical Issued Notice of Allowance for Key Absorbable Skin Stapler Patent 3Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 2Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 3Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 4Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 5Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 6Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 7Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 8Endo Pharmaceuticals Announces Agreement to Acquire Qualitest Pharmaceuticals for $1.2 Billion 9
A budget-priced microscope designed for ENT and neuro surgery....
Carl Zeiss has created a special configuration of the OPMI pico surgical microscope for neurosurgical applications, combining the benefits of optical excellence and superb illumination with outstandi...
... MS2 is designed to perfectly perform in ... use. The Leica MS2 combines the ultra ... with a innovative stand concept including automatic ... ABC balancing system for the microscope as ...
Galilean Loupes...
Medicine Products: