Navigation Links
DCA research on brain cancer
Date:5/12/2010

Edmonton, AB Medical Researchers at the University of Alberta reported today evidence that the orphan generic drug Dichloroacetate (DCA) may hold promise as potential therapy for perhaps the deadliest of all human cancers: a form of brain cancer called glioblastoma. The report is published at the journal Science Translational Medicine, a journal of the American Association of the Advancement of Science; it appears today at the journal's web site http://www.sciencemag.org/

In 2007 the U of A team led by Dr. Evangelos Michelakis, published evidence that DCA reverses cancer growth in non-human models and test tubes. The team showed then that DCA achieves these antitumor effects by altering the metabolism of cancer. By altering the way cancer handles its nutrient fuels, specifically the sugars, DCA was able to take away cancer's most important strength, the resistance to death. Since then, several independent groups across the world have confirmed the Alberta team's findings. In December 2009, the editors of "Science" predicted that cancer metabolism is one of only 5 areas across all scientific disciplines, to "watch for major breakthroughs" in 2010.

The U of A team set out to show that the way that DCA works in actual patients is the same with the way it works in the lab. In addition, researchers wanted to show whether DCA is safe and possibly effective in very sick patients with brain cancer.

By extracting glioblastomas from 49 patients over a period of 2 years and studying them within minutes of removal in the operating room, the team showed that tumors respond to DCA by changing their metabolism. Then, the team treated 5 patients with advanced glioblastoma and secured tumor tissues before and after the DCA therapy. By comparing the two, the team showed that DCA works in these tumors exactly as was predicted by test tube experiments. This is very important because often the results in n
'/>"/>

Contact: Noreen Remtulla
noreen.remtulla@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. The International Meeting for Autism Research (IMFAR)
2. OUHSC receives $100,000 Grand Challenges Explorations grant for innovative global health research
3. Cost Savings from Mobile Health Monitoring to Reach $1.9 billion to $5.8 Billion Globally by 2014 says Juniper Research
4. Trans-Atlantic agreement a boost to neuroscience research
5. Researchers discover new way to rescue treatment sensitivity of breast cancer cells
6. Georgetown Research Center Helps Reporters Decipher Health Reform Law & Impact on State Residents
7. Mild-mannered metabolic helper rushes to fight invading viruses, researchers report
8. Mayo-led research team develop agents that keep insulin working longer
9. UT Southwestern researchers uncover Fragile X syndrome genes role in shaping brain
10. Brains master switch is verified by Iowa State University researcher
11. Accumed Research Associates Expands Capabilities In Phase I and Bioequivalence Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... The University of Scranton has ... Informatics to answer the growing demand for professionals ... comprehensive wellness profile for better individual, real-world care. ... and implementation of health services and systems. This ... managerial operations in the healthcare sector,” says Margarete ...
(Date:4/21/2015)... In early April, Autism Awareness Month, monuments ... attention to a growing global crisis. One area that ... unique educational needs of individuals on the spectrum. ... and each autistic person is unique and distinctive, there ... educational and emotional needs of individuals on the spectrum ...
(Date:4/21/2015)... Los Angeles, CA (PRWEB) April 21, 2015 ... Color Spider Straps offerings. All products are listed on the ... are a favorite of EMS workers who want a quality ... Lifeguard Master spokesperson, “Our Spider Straps and color Spider Straps ... are easy to use and made of sturdy, heavy nylon” ...
(Date:4/21/2015)... San Ramon, CA (PRWEB) April 21, 2015 ... today announced Linda Burnes Bolton, DrPH, RN, FAAN, will ... Healthcare Transformation - in Long Beach, CA on October ... current President of the American Organization of Nurse Executives ... position. As past president of the American Academy of ...
(Date:4/21/2015)... 21, 2015 The Science Museum of Virginia ... addition to its Lunch Break Science program. On Wednesday, April ... – taking guests from the subatomic world of quantum mechanics ... Museum invites members of the community to grab lunch and ... physicist. Guests will delve into the nucleus and dissect the ...
Breaking Medicine News(10 mins):Health News:The University of Scranton Launches Online MS in Health Informatics 2Health News:The University of Scranton Launches Online MS in Health Informatics 3Health News:In Light of Autism Awareness Month,The Glenholme School Illuminates the Benefits of Therapeutic Boarding School for Students on the Spectrum 2Health News:In Light of Autism Awareness Month,The Glenholme School Illuminates the Benefits of Therapeutic Boarding School for Students on the Spectrum 3Health News:In Light of Autism Awareness Month,The Glenholme School Illuminates the Benefits of Therapeutic Boarding School for Students on the Spectrum 4Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 2Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 3Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 4Health News:Nationally Recognized Nurse Leader Linda Burnes Bolton to Present Keynote Address at CALNOC Conference 2Health News:Quarks and Forks at the Science Museum of Virginia 2
... some people who take aspirin to beat off heart attacks ... were. Heart attacks are caused by clots. Doctors often recommend ... ,Aspirin works by blocking the formation of thromboxane A2, ... promotes blood clotting. The study found that as many as ...
... Sustained-release sodium fluoride in combination with calcium citrate ... of fractures and increase spinal bone mass in ... the University of Texas Southwestern Medical Center concluded. ... therapy safely reduces the risk for fractures by ...
... are more prone to develop dental caries, according to ... Research Center.//"This study should serve as a pragmatic wake-up ... in smoking around their children," said pediatrician Andrew Aligne, ... the survey. The children in the study had dental ...
... in US have found that African American women with ovarian ... causes more deaths than any other cancer of the female ... independent risk factor in prognosis. US researchers have studied the ... women with ovarian cancer. They find that the mean age ...
... to experts, monounsaturated fats and carbohydrates can be included ... more variety. Research done by Dr. Anurag Garg and ... the benefits// of mono-unsaturated fats on heart health. New ... fats like olive, canola and peanut oil and carbohydrates. ...
... known as defibrillators in people who have had heart attacks ... say the findings will likely lead to a dramatic and ... attack patients by adding a $20,000 defibrillator to the medicines ... to test the preventive use of these devices in people ...
Cached Medicine News:
(Date:4/20/2015)... 2015 Actavis plc (NYSE: ACT ... , Chief Communications Officer, will retire from Actavis ... conjunction with Mayr,s retirement, Alex Kelly , ... Chief Communications Officer, effective immediately. Prior to joining ... President, Chief Communications Officer, Public Affairs and Investor ...
(Date:4/20/2015)... April 20, 2015   Precision Image Analysis ... to highlight advances in cardiovascular imaging and post-processing. ... the Society for Cardiovascular Magnetic Resonance (SCMR) ... improvements in patient management by providing broader access to ... help attendees to better understand appropriate use of CMR, ...
(Date:4/20/2015)... 2015   Spirox Inc., a privately held ... an $18.5 million Series B round of financing led by ... Partners, Correlation Ventures and Western Technology Investment also ... a novel, minimally invasive system to be used ... plastic surgeons to treat patients with nasal obstruction, ...
Breaking Medicine Technology:Actavis Announces Retirement of Charles M. Mayr 2Actavis Announces Retirement of Charles M. Mayr 3Educational Webinar Teaches Improved Patient Management Through Broader Access to Cardiac MRI 2Spirox, Inc. Announces Closing of $18.5MM Series B Financing 2Spirox, Inc. Announces Closing of $18.5MM Series B Financing 3
... WARSAW, Ind., Dec. 13, 2010 Zimmer Holdings, Inc. (NYSE: ... musculoskeletal care, announced today that the Trabecular Metal ... highest reimbursement premium percentage granted to-date for an orthopaedic product ... Medical Council, otherwise known as the Chuikyo, awarded Zimmer,s ...
... Mass., Dec. 13, 2010 Generex Biotechnology Corporation ( ... announced today that the peer-reviewed scientific journal Diabetes, ... in respect of Generex Oral-lyn™, the Company,s proprietary buccal ... Buccal spray insulin in subjects with impaired glucose tolerance: ...
Cached Medicine Technology:Zimmer Awarded Premium Pricing for Trabecular Metal™ Modular Cup in Japan 2Zimmer Awarded Premium Pricing for Trabecular Metal™ Modular Cup in Japan 3Generex Announces Publication of New Positive Generex Oral-lyn™ Data in Peer-Reviewed Journal 2Generex Announces Publication of New Positive Generex Oral-lyn™ Data in Peer-Reviewed Journal 3Generex Announces Publication of New Positive Generex Oral-lyn™ Data in Peer-Reviewed Journal 4Generex Announces Publication of New Positive Generex Oral-lyn™ Data in Peer-Reviewed Journal 5
Advanced ergonomic design allows greater comfort even after long hours of use. The focus knob and stage handle are located equidistant from the operator, permitting one-handed operation in a natural ...
... slight change in the difficulty score for ... from the best corrected visual acuity examinations ... The original charts difficulty scores were derived ... addition to the revised arrangement of letters ...
... Cube is used to diagnose Stereo and Binocular ... of polarized glasses. The test can be ... visual attention, form and depth perception. The Stereo ... 450 seconds of arc and is ideal for ...
... This "natural" Stereotest consists of three test ... acuity measurements in a range of 600 - ... hidden shape can only be detected if stereopsis ... without the risk of the patient learning the ...
Medicine Products: