Navigation Links
DAI provides potential imaging biomarker to indicate brain tumor response to RT

Orlando, Fla., February 8, 2013 Diffusion abnormality index (DAI) shows promise as an imaging biomarker to measure brain tumor response to radiation therapy, according to research being presented at the 2013 Cancer Imaging and Radiation Therapy Symposium. This Symposium is sponsored by the American Society for Radiation Oncology (ASTRO) and the Radiological Society of North America (RSNA).

The study included 20 patients who had brain metastases and were treated with whole brain radiotherapy. The total of 45 lesions among the patients was further categorized as 16 responsive, 18 stable and 11 progressive lesions. Diffusion measurements were taken prior to radiation treatment, two weeks after the start of treatment and one month after treatment completion. For each patient, a normal tissue apparent diffusion coefficient (ADC) histogram was used to divide the tumor ADC histogram into three regions: low (high cellularity), normal and high (edema and necrosis) diffusion. Analyzing the complex behavior in ADC of brain metastases from pre-radiation therapy to two weeks after starting treatment, investigators developed a new diffusion index, the DAI, which included both low and high ADC contributions, for prediction of post-treatment tumor response.

Sensitivity and specificity of the change in DAI from pre- to the end of therapy were evaluated and compared with the changes in gross tumor volume from pre-treatment to the end of therapy. The changes were valuable in predicting non-responsive lesions post-treatment. Early prediction of brain tumor response to radiation therapy is vital in providing the most appropriate radiation doses to each lesion.

"While this review included a small number of patients, the data demonstrate that DAI may be a good biomarker to predict brain tumor response," said lead study author Reza Farjam, a PhD candidate in biomedical engineering focused on cancer functional imaging at the University of Michigan in Ann Arbor, Mich. "Further study of this method is needed to improve early prediction of tumor response to radiation therapy and to help us provide brain cancer patients with more accurate information about their treatment progress."


Contact: Michelle Kirkwood
American Society for Radiation Oncology

Related medicine news :

1. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
2. Study of half siblings provides genetic clues to autism
3. Partnership provides inclusive workout
4. 16th-century Korean mummy provides clue to hepatitis B virus genetic code
5. Now Provides Competitive Car Insurance Quotes To Missouri Drivers
6. Provides SEO Services with PayPal Verified Option
7. Now Provides Competitive Car Insurance Quotes To Maryland Drivers
8. Wake Forest Baptist research provides clue to unexplained excited delirium deaths
9. Autism Speaks provides strategies to help a child with autism shows difficult behaviors
10. Now Provides Competitive Car Insurance Quotes To South Carolina Drivers
11. Now Provides Competitive Car Insurance Quotes To Louisiana Drivers
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... An inventor from Charlottesville, Va., is concerned ... last baby had high blood pressure due to loud noises," she said, "so I ... from noise pollution as well as radio waves and microwaves." , The baby BABY ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... suite of automated breast density assessment and enterprise analytics solutions, here at ... 4, 2015 (South Hall booth #2377). Volpara’s quantitative breast imaging tools enable ...
(Date:11/30/2015)... ... November 30, 2015 , ... Holcomb – ... leading plastic surgery practices in Florida, is proud to announce that Dr. Joshua ... innovations giant Ethicon Inc., a Johnson & Johnson Company. , Ethicon is a ...
(Date:11/30/2015)... ... November 30, 2015 , ... The successful filing of an Investigational ... it is so important to this key industry segment, Regis Technologies has decided to ... on December 4th at 11am EST. , Federal law does not allow new drugs ...
(Date:11/30/2015)... Phoenixville, PA (PRWEB) , ... November 30, 2015 ... ... all of the assets of DataTrade Solutions Inc., a Healthcare IT consulting, development ... by utilizing the programming and technical experience available within DataTrade to extend the ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015 ... of the "Orphan Drugs Market 2015-2019" ... ) has announced the addition of the ... offering. --> Research and Markets ( ... "Orphan Drugs Market 2015-2019" report to ...
(Date:11/30/2015)... , Nov. 30, 2015   Royal ... announced the launch of Radiology Solutions, a fully ... Radiology Solutions comprises customized, data-driven practice management approaches ... to help radiology practices improve care delivery and ... 2015 Radiological Society of North America Annual Meeting ...
(Date:11/30/2015)... SAN FRANCISCO , Nov. 30, 2015 ... and Designers of Things (DoT ) co-located events ... Printing and the Internet of Things, will draw more ... San Jose Convention Center. The events, combined ... their latest technologies. --> ...
Breaking Medicine Technology: