Navigation Links
Cytomegalovirus might speed brain-cancer growth
Date:5/31/2013

COLUMBUS, Ohio A virus that infects most Americans but that usually remains dormant in the body might speed the progression of an aggressive form of brain cancer when particular genes are shut off in tumor cells, new research shows. The animal study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) and at Dana Farber Cancer Institute suggests that cytomegalovirus (CMV) might significantly accelerate the development and progression of glioblastoma, a deadly form of brain cancer.

The virus by itself does not cause cancer, the study suggests, but it might influence tumor development when changes occur that silence two genes called p53 and Nf1 in tumor cells. These genes are protective "tumor suppressor" genes that normally cause cells to die before they become malignant. But cancer-related changes can silence them, enabling malignant cells to survive, multiply and form tumors.

The findings are published in the journal Cancer Research. Some 50 to 80 percent of Americans become infected with CMV by age 40. The virus is transmitted by contact with infected saliva and other body fluids, and through sexual contact. Most people are infected early in life and then the virus remains dormant.

"CMV has been detected in many cancer types, suggesting that it might be reactivated when cancer occurs in the body," says co-corresponding author and researcher Dr. Chang-Hyuk Kwon, assistant professor of neurological surgery, at the OSUCCC James and at the Dardinger Center for Neuro-oncology and Neurosciences.

The researchers also learned that CMV stimulates tumor-cell proliferation by activating a biochemical cell pathway called STAT3. In healthy cells, STAT3 plays an important role in controlling cell proliferation.

"Our data indicate that CMV contributes to glioblastoma when already-mutated cancer cells proliferate using the STAT3 s
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Transfusions With Heart Surgery Might Raise Infection Risk
2. Weight Loss Might Ease Psoriasis, Study Hints
3. Word Tests at Age 2 Might Predict Gains for Kids With Autism, Study Finds
4. Nano Medicine Might Someday Free Diabetics From Daily Needles
5. Fish Oil Pills Might Cut Diabetes Risk, Researchers Say
6. Certain COPD Meds Might Raise Heart Risks, Study Says
7. Living Near Fast-Food Outlets Might Boost Obesity Risk
8. NC coal plant emissions might play role in state suicide numbers
9. A Little Formula Might Help Breast-Feeding for Some Babies
10. Red Hair Pigment Might Raise Melanoma Risk: Study
11. Just How Might Exercise Lower Breast Cancer Risk?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... DC (PRWEB) July 28, 2014 As ... many are looking to private exchanges. “Private Exchange ... August 6 webinar from Atlantic Information Services, will provide ... private exchange strategies for the future. , Barbara Gniewek, ... PwC with extensive experience in the private exchange sector ...
(Date:7/28/2014)... According to the Heartburn No More PDF review recently updated ... people get rid of acid reflux naturally. This ... and acid reflux. In addition, inside this book, people will ... for reflux disease. , Vkool informs in its review ... of reflux disease naturally without medications. The book also instructs ...
(Date:7/28/2014)... 28, 2014 Building a sense of ... important. Where personal outdoor space is not possible, ... enjoy fun and exercise outside is important. That’s ... in quality commercial playground equipment from APCPLAY. , Old ... Midlothian, Virginia. It is an historic tourist location of ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Greta Pontarelli, 63, ... the Masters Champion title at the World Pole Sports Championships ... obstacle for this athlete. She is the only U.S. competitor ... the International Pole Sports Federation (IPSF). Over 150 athletes ranging ... took part in the competition. Pontarelli scored first place in ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Dr. Alan Xenakis, ... “DOC X MD Funny Feelings.” The new book, DOC ... Feelings in a unique story telling style with humor and ... and motivational. The reader will find answers to those age-old ... running water make people pee? Why do mosquitoes bite some ...
Breaking Medicine News(10 mins):Health News:Three PwC Consultants to Offer Insurers Successful Strategies for Private Exchanges 2Health News:Heartburn No More Pdf Review Exposes Jeff Martin's Guide For Treating Heartburn – Vkool.com 2Health News:Heartburn No More Pdf Review Exposes Jeff Martin's Guide For Treating Heartburn – Vkool.com 3Health News:Playground Creates Outdoor Fun for Community at Old Buckingham Station at Midlothian Village (VA) with APCPLAY© 2Health News:Inspiring Senior Athlete Lands Third World Title in One Year 2Health News:New Book by Alan P. Xenakis, MD Reveals Mind and Body Mysteries 2
... gene determines people’s sensitivity to pain.In the study conducted ... prevented by blocking the expression of that particular gene ... a breakthrough in development of new painkillers. ... them had the genetic variant that protects them from ...
... pills for easier swallowing can be dangerous as the tablet’s ... body and crushing could cause serious side effects. ... said, “People can opt to take drugs in patch, liquid ... 60% of the older people. Studies have revealed that tablets ...
... at National University of Singapore recently by researchers, reported ... edition, to study the tangible benefits of curries commonly ... regular consumption of meals which are accompanied by a ... the brain which is often indelibly associated with aging. ...
... Butler, a pioneering plastic and reconstructive surgeon has been ... ethics committee of the Royal Free Hospital, London to ... ,However the Royal College of Surgeons has called for ... transplantation. ,The surgery promises to transform the lives ...
... Sanofi-Aventis' Accomplia (rimonabant), a new drug for treatment of obesity, ... cardiac problems// in people with diabetes type 2. The research was ... in Europe and south and North America. ,Some of them ... others were treated with a placebo, for a 1 year period. ...
... dengue in the capital Thursday taking the death toll in India ... a considerable// fall in the number of fresh cases. ... days with only 74 cases being reported Wednesday across the country, ... ,Officials said it was easily one of the ...
Cached Medicine News:Health News:Gene determines pain threshold... 2Health News:Spices in curries spruce up aging minds 2Health News:Green Signal given to Full-Face Transplants 2Health News:Green Signal given to Full-Face Transplants 3
(Date:7/25/2014)... Trinidad and Tobago , July 25, 2014 ... the Trinidad & Tobago Ministry of Health approved ... therapy that significantly increases the cure rate from ... infected with the genotype 1 virus. Telaprevir is ... the trade brand INCIVO®. Photo - ...
(Date:7/25/2014)... 25, 2014 According to a ... and China Insulin Market (Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting, Premixed, ... Growth, Trends and Forecast (Value and Volume), 2013 - ... 19.99 billion in 2012 and is expected to grow ... to reach USD 32.24 billion in 2019. ...
(Date:7/25/2014)... BERWYN, Pa. , July 25, 2014  AMETEK, ... appointment of Kurtis L. Goos as Vice ... Engineered Materials, Interconnects and Packaging (EMIP) Division. ... has extensive general management and business development experience, especially ... to make important contributions to the continued growth and ...
Breaking Medicine Technology:The Hepatitis C virus is the main cause of liver transplant in the world 2The Hepatitis C virus is the main cause of liver transplant in the world 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 2Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 4AMETEK Names Kurtis L. Goos, Vice President & General Manager, Engineered Medical Components 2
... Features Give Molecular Laboratories Increased Efficiencies and Flexibility ... and is Unique in its Ability to Detect and ... Measure All Known Strains of HIV-1, ... ),has received a supplemental Premarket Approval from the U.S. Food and ...
... Solvay Pharmaceuticals, Inc. and,Wyeth Pharmaceuticals, a division of ... an action letter from the U.S. Food and Drug ... for bifeprunox, an,atypical antipsychotic that was reviewed for the ... stable adult patients. The,Agency stated that the drug was ...
Cached Medicine Technology:Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test 2Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test 3Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test 4Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test 5Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test 6Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia 2Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia 3
Inquire...
... MicroAire Power Assisted Lipoplasty Device uses a 2-mm ... facilitate the movement of the cannula in tissue. ... with more fibrous tissue. That makes the lipoplasty ... will ease your mind to learn that the ...
... 1/3 hp. 0-8 scfm/0-29.8 in.hg.@sea level. Incredibly ... to 4 collection canister systems at one ... changes during the procedure. Standard canister set-up ... filters not included). UL, c-UL and CE ...
... new term being used today to describe the nature ... that may have been used in silicone implants in ... is not new technology cohesive is simply a ... together nature of the gel. All of Mentor silicone ...
Medicine Products: