Navigation Links
Cytomegalovirus might speed brain-cancer growth
Date:5/31/2013

COLUMBUS, Ohio A virus that infects most Americans but that usually remains dormant in the body might speed the progression of an aggressive form of brain cancer when particular genes are shut off in tumor cells, new research shows. The animal study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) and at Dana Farber Cancer Institute suggests that cytomegalovirus (CMV) might significantly accelerate the development and progression of glioblastoma, a deadly form of brain cancer.

The virus by itself does not cause cancer, the study suggests, but it might influence tumor development when changes occur that silence two genes called p53 and Nf1 in tumor cells. These genes are protective "tumor suppressor" genes that normally cause cells to die before they become malignant. But cancer-related changes can silence them, enabling malignant cells to survive, multiply and form tumors.

The findings are published in the journal Cancer Research. Some 50 to 80 percent of Americans become infected with CMV by age 40. The virus is transmitted by contact with infected saliva and other body fluids, and through sexual contact. Most people are infected early in life and then the virus remains dormant.

"CMV has been detected in many cancer types, suggesting that it might be reactivated when cancer occurs in the body," says co-corresponding author and researcher Dr. Chang-Hyuk Kwon, assistant professor of neurological surgery, at the OSUCCC James and at the Dardinger Center for Neuro-oncology and Neurosciences.

The researchers also learned that CMV stimulates tumor-cell proliferation by activating a biochemical cell pathway called STAT3. In healthy cells, STAT3 plays an important role in controlling cell proliferation.

"Our data indicate that CMV contributes to glioblastoma when already-mutated cancer cells proliferate using the STAT3 signaling pathway," Kwon says. "We believe that CMV's action occurs in the tumor's cells of origin early in tumor initiation."

The findings raise questions about how cancer is studied, says co-corresponding author Dr. E. Antonio Chiocca, chairman of neurosurgery at the Brigham and Women's Hospital and surgical director for the Center for Neuro-oncology at Dana-Farber Cancer Institute in Boston.

"First, we usually study cancer in models that are virus-free, but our findings suggest that CMV might play a significant role in human cancers," he says.

"Secondly, anti-viral therapy against CMV might now be justified for human cancers, and immune responses to such cancer-modulating viruses should be carefully studied," Chiocca says.

About 18,500 new cases of glioblastoma multiforme are expected annually in the U.S., and 12,760 Americans are expected to die of the disease.

Kwon, Chiocca and their colleagues conducted the study using two mouse models infected with murine CMV (MCMV). One model developed glioblastoma spontaneously; the other received implants of human glioblastoma cells. Key technical findings include:

  • MCMV-infected mice with genetic mutations in p53 and NF1 in their brain cells that predisposed them to spontaneous glioblastoma had shorter survival than non-MCMV-infected mice with the same mutations;
  • Implanting human gliomas into the brains of MCMV-infected animals significantly shortened their survival compared with controls;
  • MCMV infection increased levels of activated STAT3 in neural stem cells, the cells in which glioblastoma is thought to originate;
  • Human CMV increased STAT3 activation and proliferation of patient-derived glioblastoma cells; a STAT3 inhibitor reversed this effect in cell and animal models.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. Transfusions With Heart Surgery Might Raise Infection Risk
2. Weight Loss Might Ease Psoriasis, Study Hints
3. Word Tests at Age 2 Might Predict Gains for Kids With Autism, Study Finds
4. Nano Medicine Might Someday Free Diabetics From Daily Needles
5. Fish Oil Pills Might Cut Diabetes Risk, Researchers Say
6. Certain COPD Meds Might Raise Heart Risks, Study Says
7. Living Near Fast-Food Outlets Might Boost Obesity Risk
8. NC coal plant emissions might play role in state suicide numbers
9. A Little Formula Might Help Breast-Feeding for Some Babies
10. Red Hair Pigment Might Raise Melanoma Risk: Study
11. Just How Might Exercise Lower Breast Cancer Risk?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 23, 2017 , ... CLICKco ... and espresso drink, announced its CLICK® Coffee Protein Drink is now available for ... Drink Mix has become popular among health-conscious consumers who love coffee but are ...
(Date:1/24/2017)... (PRWEB) , ... January 23, 2017 , ... ... presence in Texas with the acquisitions of two personal care service companies: Padre ... Texas City, Texas, effective January 1, 2017. , Well regarded in their respective ...
(Date:1/23/2017)... ... January 23, 2017 , ... A Northwestern Pennsylvania addiction ... address. Alpine Springs Rehabilitation & Recovery Center’s new website can be found at ... with its redesigned and retooled website. The treatment center has also revamped its ...
(Date:1/23/2017)... (PRWEB) , ... January 23, 2017 , ... ... education and high-level training standards for healthcare treatment providers who treat the full ... its Presidents Council. , The Presidents Council consists of the leading eating ...
(Date:1/23/2017)... ... January 23, 2017 , ... Zachary Cattell, President of ... a healthcare industry expert at the 2017 Sector Summit hosted by Ivy Tech ... Business host Gerry Dick, will feature an employer and an association representative from ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... , Jan. 23, 2017  Based on its ... & Sullivan recognizes Ansell, a global leader in ... Sullivan Company of the Year Award. Ansell,s comprehensive ... a wide global footprint have placed it in ... protection market. The Company,s established product line and ...
(Date:1/23/2017)... , Jan. 23, 2017 MouthWatch LLC announced ... was ranked as the best intraoral camera on DentalCompare,s ... the #2 spot overall. The #1 product was the ... the MouthWatch intraoral camera was "…incredibly popular because it is ... camera has a small sticker price, it doesn,t sacrifice quality ...
(Date:1/23/2017)... Direct-to-consumer digital marketing strategy drives 85% ... in consumable sales, quarter-over-quarter ... ), a leader in digital health and mobile health ... Monitoring System, an all-in-one diabetes meter, today announced continued ... smart diabetes management solution. In just ...
Breaking Medicine Technology: