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Cytochroma Announces Positive Comparative Data on CTA018 in Chronic Kidney Disease Model
Date:11/6/2008

velopment for the treatment of SHPT in CKD patients undergoing dialysis. In Phase I, CTA018 Injection was well tolerated and produced clinically meaningful reductions in blood levels of PTH after less than two weeks of administration. No clinically relevant elevations in serum calcium or phosphorus were observed.

Cytochroma has granted Mitsubishi Tanabe Pharma Corporation (MTPC) exclusive rights to CTA018 in the U.S. and Asia. The companies have a co-development and co-promotion partnership in the U.S., whereas in Asia, MTPC has sole responsibility for development and commercialization in exchange for royalties.

About CTA018

CTA018 is the first compound in a new class of vitamin D hormone analogs having a novel dual mechanism of action. CTA018 is designed to be a strong activator of the vitamin D signaling pathway as well as a potent inhibitor of CYP24, the intracellular cytochrome P450 enzyme responsible for inactivation of vitamin D hormones. Based on its mechanism of action, CTA018 is expected to be safer and more effective in treating SHPT than currently available therapies. CTA018 was designed by Professor Gary H. Posner, Ph.D. and is protected under patents and patent applications exclusively licensed to Cytochroma from the Johns Hopkins University.

About Chronic Kidney Disease

According to the National Kidney Foundation, more than eight million patients in the U.S. suffer from moderate CKD (Stages 3 and 4) to severe CKD (Stage 5). Stages 3 and 4 are characterized by progressively decreasing kidney function as measured by glomerular filtration rate. In Stage 5, kidney function is minimal to altogether absent and patients require regular dialysis or a kidney transplant for survival. An estimated 70-90% of CKD patients have vitamin D insufficiency, which can lead to SHPT and resultant debilitating bone diseases. Mounting evidence continues to link vitamin D insufficiency with progression of CKD and death. CKD is caused most fre
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SOURCE Cytochroma
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