Navigation Links
Cytochroma Announces Positive Comparative Data on CTA018 in Chronic Kidney Disease Model
Date:11/6/2008

replacement therapies (paricalcitol, doxercalciferol and calcitriol) can over-stimulate intestinal absorption of dietary calcium and phosphate, leading to excessive calcium and phosphorus in the blood. These toxicities severely limit the ability of physicians to fully control SHPT with such therapies. Data presented today demonstrate that CTA018 has significantly reduced activity and half-life in human enterocytes (intestinal cells), making CTA018 Injection far less likely to cause hypercalcemia (excessive blood calcium) or hyperphosphatemia (excessive blood phosphorus).

(3) CTA018 Preserves Vitamin D Status

Currently available vitamin D hormone replacement therapies exacerbate vitamin D insufficiency, which is widespread in CKD patients. Repeated administration of these therapies induces CYP24, and consequently depletes blood levels of calcifediol, a condition known as vitamin D insufficiency. Vitamin D insufficiency has been linked to increased mortality in CKD patients. In a preclinical study of adenine-induced CKD, repeated dosing with CTA018 did not decrease blood levels of calcifediol, possibly due to its potent CYP24 inhibitory activity.

(4) CTA018 Has Constant Potency and a Wider Therapeutic Window than Paricalcitol

Current vitamin D hormone replacement therapies can induce treatment resistance in CKD patients over time. Prolonged dosing often induces CYP24 to levels that create a barrier to administered therapy, limiting effectiveness. In a preclinical study of adenine-induced CKD, CTA018 was found to have consistent effectiveness in lowering parathyroid hormone (PTH) throughout a 4-week treatment period. In contrast, paricalcitol became progressively less effective. Additionally, CTA018 exhibited a wider therapeutic window than paricalcitol, having no significant impact on serum calcium or phosphorus at doses which fully controlled SHPT.

Current Status of CTA018 Injection

CTA018 Injection is in Phase II clinical de
'/>"/>

SOURCE Cytochroma
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
3. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
4. HEI, Inc. Announces Sale of RFID Division Assets
5. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
6. Mettler-Toledo International Inc. Announces Webcast of Presentation at Thomas Weisel Partners 2007 Healthcare Conference
7. Z Trim Announces Revocation of Gregory Halpern Severence Agreement
8. Brooke Franchise Corporation Announces Selected July Results
9. Manor Care, Inc. Announces Record Date for Special Stockholder Meeting
10. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Adipex-P(R)
11. Planet Technologies Announces Agreement to Acquire Antigen Laboratories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 19, 2014 SuperCloset raises the bar ... SuperCloset continues to offer indoor growers the most efficient ... the new SuperClone Rooms with the award winning ... indoor hydroponic grow room setup. , The SuperClone Room ... SuperPonic SuperCloner 50 . The SuperClone ...
(Date:12/19/2014)... December 20, 2014 The Medspa at ... injectable filler from respected cosmetic brand Juvéderm. Voluma XC ... with age. The Medspa at Hendrick is pleased to ... skin care technology to its clients. , Voluma is ... be FDA-approved to treat the mid-face and cheek area. ...
(Date:12/19/2014)... 2014 (HealthDay News) -- All children should have their ... preferably every year, eye experts say. The new ... panel of the U.S. National Center for Children,s Vision ... age group require screening for eye problems, particularly vision ... amblyopia ("lazy eye") and strabismus (a disorder of eye ...
(Date:12/19/2014)... 19, 2014 (HealthDay News) -- The cost of cancer ... a new study finds. Researchers examined data from ... diagnosed with colorectal or lung cancer. Of those patients, ... and more than 100 had advanced cancer. Nearly ... pay their medical bills, which was linked with a ...
(Date:12/19/2014)... Dennis Thompson HealthDay Reporter ... Ebola,s entrance into the United States -- along with ... outbreak -- have highlighted cracks in the nation,s public ... health policy report released Thursday. Half of U.S. ... to infectious disease outbreaks. That was the main conclusion ...
Breaking Medicine News(10 mins):Health News:SuperCloset Continues to Innovate with New Complete Indoor Grow Room Packages, The SuperClone Rooms are the Newest Addition to the Award Winning SuperRoom Lineup 2Health News:Breakthrough New Injectable Dermal Filler Voluma XC Offered by The MedSpa at Hendrick 2Health News:Preschoolers Need Eye Screening, Experts Say 2Health News:Cancer Treatment Costs Weigh Heavily on Patients, Study Finds 2Health News:Most States Not Ready to Handle Infectious Disease Outbreaks: Report 2Health News:Most States Not Ready to Handle Infectious Disease Outbreaks: Report 3Health News:Most States Not Ready to Handle Infectious Disease Outbreaks: Report 4
... NEW YORK, Oct. 9 You may not ... if, according to health experts, you get your ... vaccinated against the virus that causes,36,000 deaths annually. ... http://media.medialink.com/WebNR.aspx?story=33948 Registered journalists can access video, ...
... ANGELES, Oct. 9 Elvira, Mistress of the,Dark, will ... dance party fundraiser benefiting AIDS Healthcare Foundation.,This wicked-cool event ... thrift,store in Hollywood at 6210 West Sunset Blvd. on ... 2007, will feature a fashion show and contest,highlighting the ...
... Tissue Donor Registry Reaches 2 ... Million Registrations ... SACRAMENTO, Calif., Oct. 9 More than two million,Californians have signed up ... & Tissue Donor Registry, doubling the,state,s number of designated donors in only ...
... House Republican Whip Roy,Blunt (Mo.) issued the following ... yesterday suggested on CNN that Democrats wouldn,t,be able ... veto of the,SCHIP bill:, "Yesterday, the House ... override the president,s veto of a bill that ...
... crossword-puzzle solver who uses the letters in some answers ... and an international group of collaborators have used data ... to identify a gene linked to non-hereditary cases of ... posted online by the journal Nature Genetics, didnt require ...
... Actor Joe Pantoliano,reveals a personal history of depression ... bipolar disorder, in a guest blog entry, http://www.nami.org/blog ... Mental,Illness (NAMI)., Pantoliano,s entry comes during Mental ... before the opening of his latest film, CANVAS, ...
Cached Medicine News:Health News:'Something Wicked!' This Way Comes: Elvira Hosts Halloween Fashion Show and Fundraiser Benefiting AIDS Healthcare Foundation 2Health News:Two Million Californians Say 'Yes!' to Organ and Tissue Donation 2Health News:Two Million Californians Say 'Yes!' to Organ and Tissue Donation 3Health News:Two Million Californians Say 'Yes!' to Organ and Tissue Donation 4Health News:'Network' approach identifies potential breast cancer susceptibility gene 2Health News:'Network' approach identifies potential breast cancer susceptibility gene 3Health News:'Network' approach identifies potential breast cancer susceptibility gene 4Health News:Actor Joe Pantoliano Discloses Depression; Talks About His Latest Movie and His Sensitive Side 2
(Date:12/17/2014)... YORK , Dec. 17, 2014 ... imaging (MRI), the MRI market is seeing new ... and breast MRI scans account for the majority ... a higher resolution of images, which are creating opportunities ... imaging (MRI) market is growing at a rate ...
(Date:12/17/2014)... MILAN , December 17, 2014 ... becoming nothing less than a hub of information concerning the ... A further addition to the recently launched ... world and has now been enriched by a new chapter ... A richly detailed and panoramic hub on ...
(Date:12/17/2014)... 17, 2014  IGI Laboratories, Inc. (NYSE MKT: IG; ... its offering of $125 million aggregate principal amount of ... Notes were offered and sold only to qualified institutional ... of 1933, as amended (the "Securities Act"). ... 3.75% per year, payable semiannually in arrears on June ...
Breaking Medicine Technology:Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4
... ROCKVILLE, Md., Jan. 31, 2011 To further its ... manufacturers, the U.S. Pharmacopeial Convention (USP) has appointed Mr. ... Sao Paulo, Brazil facility. USP is a scientific nonprofit ... people around the world through standards and related programs ...
... 31, 2011 Global Real Estate Consultants has helped ... new facility in Fremont. Global Real ... insight and transparency in the Fremont commercial real estate ... 350,000 sq. ft. state-of-the-art manufacturing facility with pilot plant ...
Cached Medicine Technology:New Interim Leadership for USP-Brazil 2Boehringer Ingelheim to Purchase Amgen's Fremont (USA) Facility 2
... based on SIREMOBIL Iso-C, the first truly ... intra-operative 3D-Mode, the 3D-dataset is immediately available ... movement. This allows the surgeon to perform ... the procedure. This 3D capability is especially ...
... restricted to small central fields, unconventional ... full field capable, all encompassing systems ... ever need to ensure the most ... also include the most important and ...
... II-i series is a wheelchair accessible, computerized ... field. ,By using SITA, the expert operating ... up to 70%. ,A patented aspherically shaped ... increase patient comfort while testing out to ...
... results. The Kowa AP-340 a new concept ... system of ultimate simplicity. Quick, comfortable procedure ... a compact, unique design profile weighing just ... features.The integration of CRT display and instrumentation ...
Medicine Products: