Navigation Links
Cytochroma Announces Positive Comparative Data on CTA018 in Chronic Kidney Disease Model
Date:11/6/2008

CTA018 Confers Therapeutic and Safety Advantages Over Current Therapies

MARKHAM, Ontario, Nov. 6 /PRNewswire/ -- Cytochroma today announced positive comparative data on a novel vitamin D analog, CTA018, at the 2008 Annual Meeting of the American Society of Nephrology (ASN) in Philadelphia. In preclinical models, CTA018 has demonstrated advantages over two marketed vitamin D hormone replacement therapies, calcitriol and paricalcitol (Zemplar(R)), the latter currently being the most widely used therapy for secondary hyperparathyroidism (SHPT) in the United States (U.S.). These data were presented in a poster presentation entitled "The Metabolic Profile of CTA018 Confers Therapeutic and Safety Advantages over Current Therapies in an Adenine-Induced Model of Chronic Kidney Disease (CKD)."

Martin Petkovich, PhD, Cytochroma's Chief Scientific Officer, stated, "CTA018 shows characteristics in a well-accepted preclinical model of uremia which strongly indicate that it will offer clear advantages to CKD patients over currently approved therapies. We look forward to seeing these advantages confirmed in ongoing and future clinical studies with CTA018 Injection."

The newly disclosed data support the following four conclusions regarding CTA018:

(1) CTA018 is a Potent VDR Agonist and CYP24 Inhibitor

CTA018 is a dual action active vitamin D analog. Like currently approved vitamin D therapies for SHPT, CTA018 is a potent activator of the vitamin D receptor (VDR), but unlike current therapies, it is also a potent and specific inhibitor of CYP24, the vitamin D catabolic enzyme. Data presented today at the ASN demonstrate that CTA018 is at least 10 times more effective than calcitriol and paricalcitol in activating the VDR, and over 7 times more effective in inhibiting CYP24 than ketoconazole, one of the most potent CYP24 inhibitors known.

(2) CTA018 has a Short Half-Life in Human Enterocytes

Currently marketed vitamin D hormone
'/>"/>

SOURCE Cytochroma
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
3. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
4. HEI, Inc. Announces Sale of RFID Division Assets
5. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
6. Mettler-Toledo International Inc. Announces Webcast of Presentation at Thomas Weisel Partners 2007 Healthcare Conference
7. Z Trim Announces Revocation of Gregory Halpern Severence Agreement
8. Brooke Franchise Corporation Announces Selected July Results
9. Manor Care, Inc. Announces Record Date for Special Stockholder Meeting
10. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Adipex-P(R)
11. Planet Technologies Announces Agreement to Acquire Antigen Laboratories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... 2014 The Mesothelioma Applied Research ... International Symposium on Malignant Mesothelioma from March 2nd through ... sessions will take place on the campus of the ... a community dinner and an awards ceremony, will be ... cover a range of topics about pleural and peritoneal ...
(Date:11/24/2014)... 2014 A new sports massage ... pain-relief service and massage therapy provider, announced it ... This newest sports massage is a ... between traditional sports massage and ESM is that ... very own "reset button,” and ESM can increase ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 SWAccessControl.com ... locks. As a matter of fact, the company is a ... its brand new magnetic locks are available at discounted prices, ... our new range of magnetic locks. This time, all of ... are popular at home and abroad, so I have confidence ...
(Date:11/24/2014)... CO, and Philadelphia, PA (PRWEB) November 24, 2014 ... provider of care coordination and disease management services ... has chosen to implement Essette’s Medical Management software ... new Essette SaaS platform in a program to ... Essette suite includes Population Health Management, Care Management, ...
(Date:11/23/2014)... Dallas, TX (PRWEB) November 24, 2014 ... Trials Review, H2, 2014" provides data on the ... information and data relating to the clinical trials ... trial numbers and their recruitment status as per ... The databook offers a preliminary coverage of disease ...
Breaking Medicine News(10 mins):Health News:2015 International Symposium on Malignant Mesothelioma Will Take Place at the National Institutes of Health Campus 2Health News:2015 International Symposium on Malignant Mesothelioma Will Take Place at the National Institutes of Health Campus 3Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 2Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 3Health News:SWAccessControl.com Is Happy To Release New Range Of Magnetic Locks 2Health News:ReAdmission Solutions, LLC Selects Essette 2Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 2Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 3Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 4
... put the outbreak in doubt. The mystery began Sept. ... cough, typically heralded by a runny// nose, sneezing, slight fever, ... ,Then in last September through early November, about three ... other symptoms suggesting that they, too, were stricken with the ...
... groups, with relatively little genetic differentiation among the people from ... study. ,Although the study used participants that may ... suggest that the frequencies of many genetic variants are distinctive ... Indian American scientist who led the study said. ...
... that neural stem cells will eventually be useful for ... and multiple sclerosis. But there may also be another ... cells. ,A Perspective article in PLoS Medic ine, ... discusses a new study in mice, published in the ...
... Drug Administration (FDA) will release its approval for consumption of ... ,Two federal scientists, Larisa Rudenko and John C. Matheson. ... milk of cloned animals and their offspring. “On no basis ... from normal animals,” they say. ,A formal recommendation ...
... was 14 months old that left her gasping for breath.// ... to trigger an allergic reaction in people allergic to it. ... a landmark experiment that set to discover-'Could eating tiny amounts ... bodies to overcome severe food allergies?' ,Preliminary results ...
... children may have a shorter life span than those with few ... new study.// ,Researchers led by Dustin Penn and Ken Smith ... living in Utah between 1860 and 1985, who bore a total ... an average of eight children each, but family size ranged from ...
Cached Medicine News:Health News:Indians Make One Major Human Race: US Study 2Health News:Is Your Child Allergic To Peanuts? 2
(Date:11/24/2014)... Nov. 24, 2014  Marta Rendon, MD, founder of the ... Raton , FL and international key opinion leader in dermatology, ... the United States to attend the international ... Turkey . Here, at this gathering of over 600 ... renowned facial plastic surgery experts from Asia ...
(Date:11/24/2014)...  Surgical Theater, LLC, announced today that their technology ... opening of Europe,s first simulation ... The SuRgical Planner (SRP) and the Surgical Navigation Advanced ... their 3D navigation and augmented reality capabilities in the ... and Chair, Department of Neurosurgery at Mount Sinai Health ...
(Date:11/24/2014)... 24, 2014  Pifflers United Chronic and Invisible ... release of results of a study of ActiPatch®, ... self-management of fibromyalgia pain. The results demonstrated that ... very significant clinically meaningful pain reduction can be ... with fibromyalgia used ActiPatch® for 7 days and ...
Breaking Medicine Technology:Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 2Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 3Pifflers United - "Supporting Anyone Living With Chronic/Invisible Illness" Reports ActiPatch Bioelectronic Therapy Relieves Chronic Pain In Fibromyalgia 2Pifflers United - "Supporting Anyone Living With Chronic/Invisible Illness" Reports ActiPatch Bioelectronic Therapy Relieves Chronic Pain In Fibromyalgia 3
... Tengion, Inc. (NASDAQ: TNGN ), a ... Vice President Finance and Chief Financial Officer of Tengion, ... Health Care Conference on Wednesday, November 30, 2011, at ... webcast of the presentation can be accessed at ...
... Nov. 21, 2011 /PRNewswire-Asia/ -- Sundia MediTech Company Inc., a ... the company was named one of the 50 best companies ... was announced at an October ceremony in Shanghai. This is ... after it was previously named in 2007 and 2008. ...
Cached Medicine Technology:Tengion to Present at Piper Jaffray 23rd Annual Health Care Conference 2
... that need an advanced ... Vision,Premier Holter System provides ... Vision Premier system,adds expanded ... comprehensive list of diagnostic,codes ...
... EK-10 single-channel,electrocardiograph features a ... keypad. It provides the,necessary ... quick and,accurate diagnosis. The ... a built in handle ...
... three contrast levels (high, 9.5 % and 6%) ... test is designed to detect very subtle changes ... evaluation or due to refractive surgery. The upper ... contrast and acuity levels as the lower two ...
... is used to evaluate both low contrast acuity ... and 12.5%) of LogMAR acuity (20/16 to 20/100) ... as the two spatial frequencies of 6 and ... for cataract documentation because eye doctors can document ...
Medicine Products: