Navigation Links
Cysts hold clues to pancreatic cancer
Date:6/3/2010

Grand Rapids, Mich. (June 3, 2010) Working with researchers from the University of Michigan and Indiana University, Van Andel Research Institute (VARI) investigators have developed a method that could be used to predict whether pancreatic cysts are benign or are precursors to invasive cancer.

More pancreatic cysts are being detected due to the widespread use of high resolution abdominal imaging. These advances in early detection, when coupled with the new findings, could result in fewer deaths from pancreatic cancer, which struck more than 42,000 Americans in 2009 and killed more than 35,000, according to the National Cancer Institute.

"Because of the difficulty in detecting pancreatic cancer in its early stages, most cancers are advanced at the time of diagnosis and recur after removal of the tumor," said VARI Senior Scientific Investigator Brian Haab, Ph.D., first author of a study published in the May issue of Annals of Surgery. "The best hope for a long-term cure may be the detection and removal of these pre-cancerous cysts."

"Dr. Haab and his colleagues have sought to address a very challenging clinical management problem regarding cystic lesions of the pancreas," said Peter J. Allen, MD, FACS, a physician and researcher specializing in pancreatic, liver, and stomach cancer at Memorial Sloan-Kettering Cancer Center. "As the use of cross-sectional imaging increases, clinicians are seeing increased numbers of patients with these lesions and it will become imperative to sort out benign from pre-malignant."

The most common and deadly form of pancreatic cancer, pancreatic ductal adenocarcinomas, develops from three types of cysts. Although the most prevalent type is too small to be detected, the other two can be found using CT or ultrasound imaging and account for 10 15% of pancreatic cancers. However, current methods can only distinguish pre-cancerous cysts from those that are benign with up to 79% accuracy.

Using fluid from a variety of cyst types, researchers looked for patterns in the variations of carbohydrate structures called glycans to determine if there were any biomarkers that could more accurately distinguish between pre-cancerous and benign cysts. They found several candidates, some of which could be used in combination to determine cyst type.

"Further study will be needed to validate the clinical value of using glycan variations to differentiate cyst types, but it seems like they are more accurate than current methods," said Dr. Haab.

"(Dr. Haab's) identification of variants of MUC-1, MUC-5AC, and MUC-16 (genes) within the cyst fluid of pre-malignant lesions is exciting as our current ability to non-operatively define these lesions is limited," said Dr. Allen. "Hopefully with larger numbers of patients these results can be validated and be put into clinical use."


'/>"/>

Contact: Joe Gavan
joe.gavan@vai.org
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Related medicine news :

1. Tracking PSA Test Results Over Time Gives Clues to Cancer
2. New Clues to Treating Immune System Disorders
3. New Clues to Treating an Aggressive Breast Cancer
4. Pigs Yield Clues to Cystic Fibrosis-Related Lung Disease
5. New Clues Shed Light on Sperm Function, Male Fertility
6. Ovarian cancer study offers vital clues for new therapies
7. Change in breast density over time provides clues about breast cancer risk
8. Lab that probes genetic clues to disease is poised for major expansion
9. More Clues Emerge on How HIV Infects Women
10. Scientists Find Clues to How the Body Fights Off HIV
11. New Clues to Pregnancy-Associated Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... ... February 26, 2017 , ... ... technology standard in staffing, scheduling, and reporting for healthcare organizations. This comprehensive ... throughout the entire staffing process. StaffBridge technology improves staffing efficiency, maximizes resource ...
(Date:2/25/2017)... Viejo, CA (PRWEB) , ... February 25, 2017 , ... ... with ProSharpen Color tools from Pixel Film Studios. With ProSharpen Color users have total ... sliders to easily refine their color range. With color spectrum tools users can visually ...
(Date:2/24/2017)... Princeton, NJ (PRWEB) , ... February 24, 2017 ... ... organization that provides business development, education, networking and recognition opportunities as well as ... at Bell Works in Holmdel, NJ on February 23. The Council's Innovation ...
(Date:2/24/2017)... ... February 24, 2017 , ... In the Health Care IT campaign, ... priority because it’s not if you will be attacked, but when.” However, he and ... to digital health care. , Improvements in auditing and monitoring have taken security in ...
(Date:2/24/2017)... , ... February 24, 2017 , ... With ProGlass Prism ... Pro X . Users have total control over position, rotation, distortion, edge softness, edge ... within Final Cut Pro X. , With ProGlass Prism users are given the tools ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 24, 2017 Medical information groups within ... their self-service capabilities to manage inquiries from external ... New research from consulting leader Best Practices, ... self-service website portals where HCPs can sign on ... of many findings to emerge from the new ...
(Date:2/24/2017)... 24. Februar 2017 ITL Limited, ( ... Gesundheitsbereiches, ist erfreut, für das zum 31. Dezember ... Vorjahreszeitraum exzellente Ergebnisse vorlegen zu können. Eine vollständige ... Wachstum" finden Sie hier . ... Steuern 2,12 Millionen USD (Dez. 2015: 1,04 Millionen USD; +104 %) ...
(Date:2/24/2017)... Feb. 23, 2017 Non-alcoholic steatohepataitis ... the various drugs being developed for the ... the drugs that are in various phases ... pipeline focuses on novel pharmacologic drugs & ... cell therapies, recombinant proteins and RNA-based therapeutics, ...
Breaking Medicine Technology: