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Cystic Fibrosis Drug Combo May Be Less Effective Than Hoped
Date:7/23/2014

ts treated with this drug combination," Gentzsch said.

Scientists believe Kalydeco helps water escape cells so it can moisten mucus, while lumacaftor paves the way for liquid to get where it's supposed to go. But the study suggests Kalydeco disables some of lumacaftor's effects.

Gentzsch said other medications and other combinations of treatments could indeed benefit patients. Future research into how they affect specific types of patients could lead to more insight into whether they're worthwhile treatments, she said.

The study by Gentzsch and colleagues appears in the July 23 issue of Science Translational Medicine. It was funded by the U.S. National Institutes of Health, the Cystic Fibrosis Foundation, and the Else Kroner-Fresenius Foundation.

More information

For more details about cystic fibrosis, visit the Cystic Fibrosis Foundation.

SOURCES: Martina Gentzsch, Ph.D., assistant professor, department of cell biology and physiology, University of North Carolina, Chapel Hill; Alan Smyth, M.D., professor of child health and division head, University of Nottingham, U.K.; July 23, 2014, statement, Vertex; July 23, 2014, Science Translational Medicine


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